DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and CYP2C8

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_000761.3	Gene:	CYP2C8 / 1558	HGNCID:	2622	Length:	490	Species:	Homo sapiens

Alignment Length:	522	Identity:	148/522 - (28%)
Similarity:	244/522 - (46%)	Gaps:	55/522 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKD 65
            |...:.|...|...:::||...:.|.:..||||..:|.:||.||...:.....     |..::|.
Human     1 MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKS-----FTNFSKV 60

  Fly    66 FRSDLVGLKLGREYVVVALGHEMVKEVQLQ--EVFEGRPDNFFLRLRTMGTRKGITCTDGQLWYE 128
            : ..:..:..|...:||..|:|.|||..:.  |.|.||.::...:..|.|.  ||..::|:.|.|
Human    61 Y-GPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGL--GIISSNGKRWKE 122

  Fly   129 HRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRI 193
            .|.|::..:||.|.|:..:|..::.||..|:.:|.:|:..|.:|...|..:..||:..::..||.
Human   123 IRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRF 187

  Fly   194 ARQEDGTLRRLLDLMNRRSKLF--------DICGG---LLAQFPW-----LRHVAPDRTGYNLIQ 242
            ..::    :..|.||.|.::.|        .:|..   |:..||.     |::||..|:
Human   188 DYKD----QNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRS------ 242

  Fly   243 QLNTELYGFFMDTIEEHRRQL-AKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDF 306
                    :..:.::||:..| ..:|    .|.|..:|.:| ::....:.|.||...||.|:.|.
Human   243 --------YIREKVKEHQASLDVNNP----RDFIDCFLIKM-EQEKDNQKSEFNIENLVGTVADL 294

  Fly   307 FIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQ 371
            |:||::|||.|:...|::|...|:|..|:..::...:....:   |.:..|....|.||.:.|:|
Human   295 FVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRS---PCMQDRSHMPYTDAVVHEIQ 356

  Fly   372 RFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFK 436
            |:..:.|...|......||...|.|||..||:..|.||..|.:.:.:|..|.|..|:|..|...|
Human   357 RYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKK 421

  Fly   437 DEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSV--VLPAGESPSMVLLPGITLTPKPYKVQ 499
            .:|||||..|:|.|.|:.|||..:|.||..|:|:|::  |.......:..:..||...|..|::.
Human   422 SDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQIC 486

  Fly   500 FV 501
            |:
Human   487 FI 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	141/490 (29%)
CYP2C8	NP_000761.3	p450	30..487	CDD:278495	141/490 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920