DRSC/TRiP Functional Genomics Resources

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Protein Alignment Cyp305a1 and CYP2C19

DIOPT Version :9

Sequence 1:NP_649151.1 Gene:Cyp305a1 / 40161 FlyBaseID:FBgn0036910 Length:504 Species:Drosophila melanogaster
Sequence 2:NP_000760.1 Gene:CYP2C19 / 1557 HGNCID:2621 Length:490 Species:Homo sapiens


Alignment Length:526 Identity:150/526 - (28%)
Similarity:239/526 - (45%) Gaps:63/526 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKD 65
            |...:.|...|...::.|:...:......||||..:|.:||.||..                .||
Human     1 MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQID----------------IKD 49

  Fly    66 FRSDLVGLK----------LGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGI 118
            ....|..|.          .|.|.:||..|:|:|||  :.|.|.|.|| .:|.|..|. ....||
Human    50 VSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGR-GHFPLAERA-NRGFGI 112

  Fly   119 TCTDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNV 183
            ..::|:.|.|.|.|::..:||.|.|:..:|..::.||..|:.:|.:|:..|.:|...|..:..||
Human   113 VFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNV 177

  Fly   184 LWCLIAGKRIARQEDGTLRRLLDLMNRRSKL-----FDICGGLLAQFPWLRHVAPDRTGYNLIQQ 243
            :..:|..||. ..:|.....|::.:|...::     ..||.    .||.:....|. |...|::.
Human   178 ICSIIFQKRF-DYKDQQFLNLMEKLNENIRIVSTPWIQICN----NFPTIIDYFPG-THNKLLKN 236

  Fly   244 LNTELYGFFMDT-----IEEHRRQL-AKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMT 302
            |      .||::     ::||:..: ..:|    .|.|..:|.:| ::....:.|.|....||:|
Human   237 L------AFMESDILEKVKEHQESMDINNP----RDFIDCFLIKM-EKEKQNQQSEFTIENLVIT 290

  Fly   303 ILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFI 367
            ..|...||::|||.|:..||::|...|:|..|:..::...:   ..:..|.:..|....|.||.:
Human   291 AADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVI---GRNRSPCMQDRGHMPYTDAVV 352

  Fly   368 MEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAG 432
            .||||:..:.|.:.|.......|...|.|||..|||.||.||..|.:.:.:|..|.|..|:|..|
Human   353 HEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGG 417

  Fly   433 KCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSV--VLPAGESPSMVLLPGITLTPKP 495
            ...|..|||||..|:|.|:|:.|||..:|.||..|:|:|::  ::...:..:..::.|....|..
Human   418 NFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPF 482

  Fly   496 YKVQFV 501
            |::.|:
Human   483 YQLCFI 488

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Cyp305a1NP_649151.1 p450 30..500 CDD:278495 145/494 (29%)
CYP2C19NP_000760.1 p450 30..487 CDD:365848 145/494 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG45226
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000008
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X6
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.920

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