DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and CYP2B6

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_000758.1	Gene:	CYP2B6 / 1555	HGNCID:	2615	Length:	491	Species:	Homo sapiens

Alignment Length:	526	Identity:	160/526 - (30%)
Similarity:	258/526 - (49%)	Gaps:	60/526 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPK---NFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERW 62
            :|.|:|| |:|.|.:   |:...|.|.   ..|||||.:|.|||.||..:.     |....|.|:
Human     3 LSVLLFL-ALLTGLL---LLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRR-----GLLKSFLRF 58

  Fly    63 AKDFRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGR-----PDNFFLRLRTMGTRKGITC 120
            .:.: .|:..:.||...||:..|.|.::|  |...|.|.||     .|.||       ...|:..
Human    59 REKY-GDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFF-------RGYGVIF 115

  Fly   121 TDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSV-LNVL 184
            .:|..|...|.|::..||:.|.|:..:|..|:.||:.|:.:|.:::...::| |:|.||: .|::
Human   116 ANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDP-TFLFQSITANII 179

  Fly   185 WCLIAGKRIARQEDGTLRRLLDLMNRR--------SKLFDICGGLLAQFPWLRHVAPDRTGYNLI 241
            ..::.|||...|:...| ::|:|..:.        .:||::..|.|..||     ...|..|..:
Human   180 CSIVFGKRFHYQDQEFL-KMLNLFYQTFSLISSVFGQLFELFSGFLKYFP-----GAHRQVYKNL 238

  Fly   242 QQLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDF 306
            |::|    .:...::|:||..|  ||| |..|||..||..|:...:...|. |:...|.:..|..
Human   239 QEIN----AYIGHSVEKHRETL--DPS-APKDLIDTYLLHMEKEKSNAHSE-FSHQNLNLNTLSL 295

  Fly   307 FIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQ 371
            |.||::|||.|:....:::...|.|.|:::.::...:.....   |.|..|....|.:|.|.|:|
Human   296 FFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRP---PELHDRAKMPYTEAVIYEIQ 357

  Fly   372 RFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFK 436
            ||..:.|:..|......|...||.|||:..:.:.|.:...|..:::.|..|.|:.|:|:.|...|
Human   358 RFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKK 422

  Fly   437 DEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMV-LLP---GITLTPKPYK 497
            .|.|:||.:|:|.|||:.:|||.:|.|...|:|:||:..|.  :|..: |.|   |:...|..|:
Human   423 TEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPV--APEDIDLTPQECGVGKIPPTYQ 485

  Fly   498 VQFVKR 503
            ::|:.|
Human   486 IRFLPR 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	148/489 (30%)
CYP2B6	NP_000758.1	p450	42..488	CDD:278495	140/478 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920