DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and CYP2A13

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_000757.2	Gene:	CYP2A13 / 1553	HGNCID:	2608	Length:	494	Species:	Homo sapiens

Alignment Length:	515	Identity:	143/515 - (27%)
Similarity:	233/515 - (45%)	Gaps:	43/515 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRS 68
            |:.|.|.|...|:.|:....:.....||||..:|::||.||...| ........:.||:...|.
Human     8 LVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTE-QMYNSLMKISERYGPVFT- 70

  Fly    69 DLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGITCTDGQLWYEHRH 131
                :.||...|||..||:.|||  |...|.|.||.:.........|  .|:..::|:...:.|.
Human    71 ----IHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKG--YGVAFSNGERAKQLRR 129

  Fly   132 FAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQ 196
            |::..:|..|.|:..:|..|:.||..|:..|..|....|:|..:|:::|.||:..::.|.|. ..
Human   130 FSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRF-DY 193

  Fly   197 EDGTLRRLLDLM--------NRRSKLFDICGGLLAQFPWLRHVAPDRTGYNLIQQLNTELYGFFM 253
            ||.....||.:|        ....:|:::...::...|     .|.:..:..:|.|.    .|..
Human   194 EDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLP-----GPQQQAFKELQGLE----DFIA 249

  Fly   254 DTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTTSNTI 318
            ..:|.::|.|  ||: :..|.|.::|..|::... ..::.|....||||.|:.|.||::|.|.|:
Human   250 KKVEHNQRTL--DPN-SPRDFIDSFLIRMQEEEK-NPNTEFYLKNLVMTTLNLFFAGTETVSTTL 310

  Fly   319 NLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPITGPR 383
            ....::|...|:|:.|:..::...:   ..:..|....|....|.:|.|.|:|||..:.|:....
Human   311 RYGFLLLMKHPEVEAKVHEEIDRVI---GKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAH 372

  Fly   384 RALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGMGRR 448
            |....||...:.:||...:...|.||..|...:.:|.:|.|:.|:|..|:..|.:.|:||.:|:|
Human   373 RVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKR 437

  Fly   449 RCLGDALARACIFSFLVRIVQHFSVVLPAGE-----SPSMVLLPGITLTPKPYKVQFVKR 503
            .|.|:.|||..:|.|...|:|:|....|...     ||..|   |....|:.|.:.|:.|
Human   438 YCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHV---GFATIPRNYTMSFLPR 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	135/484 (28%)
CYP2A13	NP_000757.2	p450	34..491	CDD:278495	135/484 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920