Protein Alignment Cyp305a1 and CYP1A1

DIOPT Version :9

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_000490.1
• Gene: CYP1A1 / 1543
• HGNCID: 2595
• Length: 512
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 145/511 - (28%)
• Similarity: 242/511 - (47%)
• Gaps: 39/511 - (7%)

  Fly     1 MSALIFLCAILIGFVIYSLISSARR--PKNF--PPGPRFVPWLGNTLQFRKEASAVGGQHILFER 61
            |||..||.|.:|..:::.:|.::|.  ||..  ||||...|.:|:.|...|      ..|:...|
Human     7 MSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGK------NPHLALSR 65

  Fly    62 WAKDFRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGITCTDGQ 124
            .::.: .|::.:::|...|||..|.:.:::  |:..:.|:||||.:...|.:.|.....:...|.
Human    66 MSQQY-GDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGP 129

  Fly   125 LWYEHRHFAMKQMRNVGYGRS-------QMEHHIELEAEELLGQLERTEEQP--IEPVTWLAQSV 180
            :|...|..|...:::......       .:|.|:..|||.|:..|:.....|  ..|..::..||
Human   130 VWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSV 194

  Fly   181 LNVLWCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICG-GLLAQF-PWLRHVAPDRTGYNLIQQ 243
            .||:..:..|:|.    |...:.||.|:|..:...::.| |..|.| |.||::  .....|..:.
Human   195 TNVICAICFGRRY----DHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYL--PNPSLNAFKD 253

  Fly   244 LNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMK-DRSAGGESSTFNETQLVMTILDFF 307
            ||.:.|.|....::||.:...|......:|.:..:.||.: |.:|..:.|   :.:::..:||.|
Human   254 LNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLS---DEKIINIVLDLF 315

  Fly   308 IAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQR 372
            .||..|.:..|:.:||.|.|.|.||.|:..::...:..:..   |.||.|....||:|||:|..|
Human   316 GAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRR---PRLSDRSHLPYMEAFILETFR 377

  Fly   373 FFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFK- 436
            .....|.|.|......|.|.|:.|||...:.::...::.|::.|.:|.||.||||:...|...|
Human   378 HSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKV 442

  Fly   437 -DEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITL 491
             .|..:.||||:|:|:|:.:||..:|.||..::|.....:|.|....|..:.|:|:
Human   443 LSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTM 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	134/478 (28%)
CYP1A1	NP_000490.1	Mitochondrial targeting signal. /evidence=ECO:0000250|UniProtKB:P00185	29..40		3/10 (30%)
		p450	40..499	CDD:365848	134/478 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920