DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2j5

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_034137.1	Gene:	Cyp2j5 / 13109	MGIID:	1270149	Length:	501	Species:	Mus musculus

Alignment Length:	512	Identity:	156/512 - (30%)
Similarity:	257/512 - (50%)	Gaps:	47/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKDFRSDLV 71
            |...::.|:....|..:|.|||:||||..:|::||..|...:.:     |::.:::.|.: .::.
Mouse    21 LVLAVVTFLFLINILRSRHPKNYPPGPWRLPFVGNFFQIDTKQT-----HLVLQQFVKKY-GNVF 79

  Fly    72 GLKLGREYVVVALGHEMVKEVQLQEVFEGRPDNFFLRLRT-----MGTRKGITCTDGQLWYEHRH 131
            .|:||:..|||..|..::|     |:|.....||..|..|     :..:.|:..::||.|.|.|.
Mouse    80 SLELGQSPVVVVSGLPLIK-----EMFTHLDQNFVNRFMTPVRERITGKNGLVVSNGQTWKEQRR 139

  Fly   132 FAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKRIARQ 196
            .|:..:||.|.|:..:|..|:.|...|:..:.....||..|...|..:|.|::..:..|:|. ..
Mouse   140 LALMALRNFGLGKKSLEERIQEETHHLVEAIREEGGQPFNPHLKLINAVSNIICSVTFGERF-DY 203

  Fly   197 EDGTLRRLLDLMNRRSKLFDICGGLLAQ-FPWLRHVAPDRTGYNLIQQLNTELYGFFMDTIEEHR 260
            ||...:.||.|::....|.....|.|.. ||.:....|.  .:..|.:...:|..|....:::|.
Mouse   204 EDCQFQELLQLLDETMHLMGSSAGQLYNGFPCIMKYLPG--PHQKIFRNWGKLKLFVSHIVKKHE 266

  Fly   261 RQLAKDPSPAE-SDLIYAYLQEMK---DRSAGGESSTFNETQLVMTILDFFIAGSQTTSNTINLA 321
                ||.:|.| .|.|.|:|.||:   ||     :::|||..|:.|.||.|:.|::|||:|:..|
Mouse   267 ----KDWNPDEPRDFIDAFLIEMQKDPDR-----TTSFNEENLISTTLDLFLGGTETTSSTLRWA 322

  Fly   322 LMVLAMRPDVQEKLFSQVTASVAAASTDAFPH-----LSRREAFDYMDAFIMEVQRFFHITPITG 381
            |:.::..|::||.:.:::...:.        |     ||.||:..|.:|.|.||||..:|.|:..
Mouse   323 LLYMSSYPEIQENVQAEIDRVIG--------HKRQVSLSDRESMPYTNAVIHEVQRMGNIVPLNS 379

  Fly   382 PRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGMG 446
            .|.....||..|:.:||...||.:|.::|.|.:.|..|..|.||.|::: |:..|.|.|:||.||
Mouse   380 SREVTVDTKFNGFHLPKGTMILTNLTALHRDPKEWATPEVFNPEHFLEN-GQFKKRESFLPFSMG 443

  Fly   447 RRRCLGDALARACIFSFLVRIVQHFSVVLPAGESPSMVLLPGITLTPKPYKVQFVKR 503
            :|.|||:.||::.:|.|...::|.|:...|..|..|:....|:.|:|..|::..:.|
Mouse   444 KRACLGEQLAKSELFIFFSALMQKFTFKPPINEKLSLKFRMGLILSPASYRICAIPR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	148/484 (31%)
Cyp2j5	NP_034137.1	p450	44..496	CDD:278495	148/483 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920