DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp305a1 and Cyp2e1

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_067257.1	Gene:	Cyp2e1 / 13106	MGIID:	88607	Length:	493	Species:	Mus musculus

Alignment Length:	545	Identity:	149/545 - (27%)
Similarity:	241/545 - (44%)	Gaps:	93/545 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLIS---SARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERW 62
            |:.|....|:|:......|:|   ...|..|.||||..:|:.||                :|:..
Mouse     1 MAVLGITVALLVWIATLLLVSIWKQIYRSWNLPPGPFPIPFFGN----------------IFQLD 49

  Fly    63 AKDFRSDLV----------GLKLGREYVVVALGHEMVKEVQL--QEVFEGRPD-NFFLRLRTMGT 114
            .||....|.          .|.||:..:||..|::.||||.|  :..|.||.| ..|...:
Mouse    50 LKDIPKSLTKLAKRFGPVFTLHLGQRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYK---- 110

  Fly   115 RKGITCTDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQS 179
            .|||...:|..|.:.|.|::..:|:.|.|:...|..|:.||..|:.:|::|:.||.:|...:..:
Mouse   111 NKGIIFNNGPTWKDVRRFSLSILRDWGMGKQGNEARIQREAHFLVEELKKTKGQPFDPTFLIGCA 175

  Fly   180 VLNVLWCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQFPWLRHVAPDRTGYNLIQQL 244
            ..||:..::..||.    |...::.|:||:..::.|     .|...||:
Mouse   176 PCNVIADILFNKRF----DYDDKKCLELMSLFNENF-----YLLSTPWI---------------- 215

  Fly   245 NTELYGFFMDTIE----EHRR-----------QLAKDPSPAES-------DLIYAYLQEMKDRSA 287
              :.|.:|.|.::    .||:           .|.|.....:|       |:....|.|| ::..
Mouse   216 --QAYNYFSDYLQYLPGSHRKVMKNVSEIRQYTLGKAKEHLKSLDINCPRDVTDCLLIEM-EKEK 277

  Fly   288 GGESSTFNETQLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFP 352
            ..:...:....:.:|:.|.|.||::|||.|:...|::|...|:::|||..::...:..:..   |
Mouse   278 HSQEPMYTMENISVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRA---P 339

  Fly   353 HLSRREAFDYMDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWK 417
            .:..|....||||.:.|:|||.::.|...|..|...|...||.|||...::.:|.|:..|...:.
Mouse   340 AVRDRMNMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFRGYVIPKGTVVIPTLDSLLFDNYEFP 404

  Fly   418 DPLEFRPERFIDSAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHF---SVVLPAGE 479
            ||..|:||.|::..||....:||..|..|:|.|:|:.|||..:|..|..|:|||   |:|.|...
Mouse   405 DPETFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDI 469

  Fly   480 SPSMVLLPGITLTPKPYKVQFVKRT 504
            ..|.|.: |....|:.:|:..:.|:
Mouse   470 DLSPVTI-GFGSIPREFKLCVIPRS 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	140/507 (28%)
Cyp2e1	NP_067257.1	p450	44..489	CDD:278495	134/496 (27%)
Cyp2e1	NP_067257.1	Substrate binding. /evidence=ECO:0000250	298..303		2/4 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920