Protein Alignment Cyp305a1 and Cyp2d9

DIOPT Version :10

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_034136.2
• Gene: Cyp2d9 / 13105
• MGIID: 88606
• Length: 504
• Species: Mus musculus
• Alignment Length: 513
• Identity: 159/513 - (30%)
• Similarity: 250/513 - (48%)
• Gaps: 37/513 - (7%)

  Fly     7 LCAILIGFVIYSLI-----SSARRPKNFPPGPRFVPW--LGNTLQFRKEASAVGGQ-HILFERWA 63
            |..:.|..||:.|:     ...|....:||||  |||  |||.||.     .:|.. :.|::  .
Mouse     9 LWPVAIFTVIFILLVDLTHQRQRWTSRYPPGP--VPWPVLGNLLQV-----DLGNMPYSLYK--L 64

  Fly    64 KDFRSDLVGLKLGREYVVVALGHEMVKEVQL---QEVFEGRPDNFFLRLRTMGTRKGITCTD-GQ 124
            ::...|:..|::..:.:||..|.:.:||:.|   ::..:..|...|..|......:|:.... |.
Mouse    65 QNRYGDVFSLQMAWKPMVVINGLKAMKEMLLTCGEDTADRPPVPIFEYLGVKPGSQGVVLAPYGP 129

  Fly   125 LWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIA 189
            .|.|.|.|::..:||.|.|:..:|..:..||..|.........|||.|...|.:|..||:..||.
Mouse   130 EWREQRRFSVSTLRNFGLGKKSLEDWVTKEANHLCDAFTAQAGQPINPNPMLNKSTCNVIASLIF 194

  Fly   190 GKRIARQEDGTLRRLLDLMNRRSKLFDICG---GLLAQFPWLRHVAPDRTGYNLIQQLNTELYGF 251
            .:|. ..||..|.|:|.::.:  .|.::.|   .:|..||.|..:  .|.....:|  ..:.:..
Mouse   195 ARRF-EYEDPFLIRMLKVLEQ--SLTEVSGLIPEVLNAFPILLRI--PRLADKALQ--GQKSFIA 252

  Fly   252 FMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTTSN 316
            .:|.:....| ...||..|..:|..|:|.|: :::.|...|:||:..|:|.:.|.|.||..|||.
Mouse   253 ILDNLLTENR-TTWDPVQAPRNLTDAFLAEI-EKAKGNPESSFNDENLLMVVRDLFGAGMLTTST 315

  Fly   317 TINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPITG 381
            |::.|||::.:.||||.::..::...:...   ..|.::.:....|.:|.|.|||||..|.|:..
Mouse   316 TLSWALMLMILHPDVQRRVQQEIDEVIGQV---RHPEMADQAHMPYTNAVIHEVQRFGDIVPVNL 377

  Fly   382 PRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGMG 446
            ||......::..:.|||...:|.::.|:..|:..|:.||.|.||.|:|:.|...|.|.||||..|
Mouse   378 PRITSHDIEVQDFLIPKGTILLPNMSSMLKDESVWEKPLRFHPEHFLDAQGHFVKPEAFMPFSAG 442

  Fly   447 RRRCLGDALARACIFSFLVRIVQHFSVVLPAGE-SPSMVLLPGITLTPKPYKVQFVKR 503
            ||.|||:||||..:|.|...::|.||..:|.|: .||...:.||.:.|.||::..|.|
Mouse   443 RRSCLGEALARMELFLFFTCLLQRFSFSVPDGQPQPSNSGVYGILVAPSPYQLCAVVR 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	CYP15A1-like	68..498	CDD:410744	137/437 (31%)
Cyp2d9	NP_034136.2	CYP2D	68..495	CDD:410756	137/438 (31%)