DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2c37

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_034131.2	Gene:	Cyp2c37 / 13096	MGIID:	1306806	Length:	490	Species:	Mus musculus

Alignment Length:	527	Identity:	146/527 - (27%)
Similarity:	232/527 - (44%)	Gaps:	65/527 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQ---------FRKEASAVGGQH 56
            |..::.|...|....:.||...:......||||..:|.:||.||         |...:...|..:
Mouse     1 MDPILVLVLTLSCLFLLSLWRQSSERGKLPPGPTPLPIIGNILQIDVKDICQSFTNLSKVYGPVY 65

  Fly    57 ILFERWAKDFRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGIT 119
            .|:               |||:..||..|:|.|||  |...|.|.||.........|.|  .|:.
Mouse    66 TLY---------------LGRKPTVVLHGYEAVKEALVDHGEEFAGRGRFPVFDKATNG--MGLA 113

  Fly   120 CTDGQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVL 184
            .:.|.:|...|.|::..:||:|.|:..:|..::.||..|:.:|.:|...|.:|...|..:..||:
Mouse   114 FSKGNVWKNTRRFSLMTLRNLGMGKRSIEDRVQEEARCLVEELRKTNGSPCDPTFILGCAPCNVI 178

  Fly   185 WCLIAGKRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQFPWLR--HVAPDRTGY-----NLIQ 242
            ..:|...|...::    |..|:||.:.:::..|...     |||:  :..|....|     ....
Mouse   179 CSIIFQDRFDYKD----RDFLNLMEKLNEITKILSS-----PWLQICNTYPALLDYCPGSHKQFF 234

  Fly   243 QLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQ-----LVMT 302
            :....:..|.::.|:||...|  |.:.....:.|..:.       ||:.......|     |.:|
Mouse   235 KNYASIKNFLLEKIKEHEESL--DVTIPRDFIDYFLIN-------GGQEDGNQPLQNRLEHLAIT 290

  Fly   303 ILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFI 367
            :.|.|.||::|||.|:..|:::|...|.|..|:..::...:....:   |.:..|....|.||.|
Mouse   291 VTDLFSAGTETTSTTLRYAILLLLKYPHVTAKVQEEIEHVIGKHRS---PCMQDRSRMPYTDAMI 352

  Fly   368 MEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAG 432
            .|||||..:.|.:.|.......|...|.|||..|::.||.||..|...:.:|.:|.|..|:|..|
Mouse   353 HEVQRFIDLIPNSLPHEVTSDIKFRNYFIPKGTTVITSLSSVLHDSTEFPNPEKFDPGHFLDENG 417

  Fly   433 KCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFS---VVLPAGESPSMVLLPGITLTPK 494
            |..|.:||:||..|:|.|.|:.|||..:|.||..|:|:|:   :|.|.....:.:|: |:...|.
Mouse   418 KFKKSDYFIPFSTGKRICAGEGLARMELFLFLTSILQNFNLKPLVHPKDIDVTPMLI-GLASVPP 481

  Fly   495 PYKVQFV 501
            .:::.|:
Mouse   482 AFQLCFI 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	140/495 (28%)
Cyp2c37	NP_034131.2	p450	30..487	CDD:278495	140/495 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920