DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and Cyp2c29

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_031841.3	Gene:	Cyp2c29 / 13095	MGIID:	103238	Length:	490	Species:	Mus musculus

Alignment Length:	514	Identity:	156/514 - (30%)
Similarity:	242/514 - (47%)	Gaps:	39/514 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFR-KEASAVGGQHILFERWAK 64
            |..::||...|...::.||...:......||||..:|.:||.||.. |..|.      .|..::|
Mouse     1 MDLVVFLALTLSCLILLSLWRQSSGRGKLPPGPTPLPIIGNFLQIDVKNISQ------SFTNFSK 59

  Fly    65 DFRSDLVGLKLGREYVVVALGHEMVKEVQLQ--EVFEGRPDNFFLRLRTMGTRKGITCTDGQLWY 127
            .: ..:..|.||.:..|:..|:|.|||..:.  |.|.||  ..|.....:....|:..::|..|.
Mouse    60 AY-GPVFTLYLGSKPTVILHGYEAVKEALIDRGEEFAGR--GSFPMAEKIIKGFGVVFSNGNRWK 121

  Fly   128 EHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKR 192
            |.|.|.:..:||:|.|:..:|..::.||:.|:.:|.:|:..|.:|...|:.:..||:..:|...|
Mouse   122 EMRRFTLMTLRNLGMGKRNIEDRVQEEAQCLVEELRKTKGSPCDPTFILSCAPCNVICSIIFQNR 186

  Fly   193 IARQEDGTLRRLLDLMNRRSKL-----FDICGGLLAQFPWLRHVAPDRTGYNLIQQLNTELYGFF 252
            . ..:|.....|:|.:|...|:     ..:|.    .||.|....|. :.:.:::..| .|..:.
Mouse   187 F-DYKDKEFLILMDKINENVKILSSPWLQVCN----SFPSLIDYCPG-SHHKIVKNFN-YLKSYL 244

  Fly   253 MDTIEEHRRQL-AKDPSPAESDLIYAYLQEMKDRSAGG-ESSTFNETQLVMTILDFFIAGSQTTS 315
            ::.|:||:..| ..:|    .|.|..||  :|.:.... |.|.|:...|..||.|.|.||::|||
Mouse   245 LEKIKEHKESLDVTNP----RDFIDYYL--IKQKQVNHIEQSEFSLENLASTINDLFGAGTETTS 303

  Fly   316 NTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPIT 380
            .|:..||::|...|||..|:..::...|....:   |.:..|....|.||.|.|||||..:.|.:
Mouse   304 TTLRYALLLLLKYPDVTAKVQEEIDRVVGRHRS---PCMQDRSHMPYTDAMIHEVQRFIDLLPTS 365

  Fly   381 GPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGM 445
            .|.......|...|.|||..|::.||.||..|.:.:.:|..|.|..|::..|...|.:|||||..
Mouse   366 LPHAVTCDIKFRKYLIPKGTTVITSLSSVLHDSKEFPNPEMFDPGHFLNGNGNFKKSDYFMPFST 430

  Fly   446 GRRRCLGDALARACIFSFLVRIVQHF---SVVLPAGESPSMVLLPGITLTPKPYKVQFV 501
            |:|.|.|:.|||..:|..|..|:|:|   |:|.|. |.....::.|....|.||::.|:
Mouse   431 GKRICAGEGLARMELFLILTTILQNFKLKSLVHPK-EIDITPVMNGFASLPPPYQLCFI 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	149/482 (31%)
Cyp2c29	NP_031841.3	p450	30..487	CDD:278495	149/482 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920