Protein Alignment Cyp305a1 and Cyp2a4

DIOPT Version :10

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: NP_034127.2
• Gene: Cyp2a4 / 13086
• MGIID: 88596
• Length: 494
• Species: Mus musculus
• Alignment Length: 519
• Identity: 142/519 - (27%)
• Similarity: 237/519 - (45%)
• Gaps: 45/519 - (8%)

  Fly     2 SALIFLCAI--LIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAK 64
            |.|:.:.|:  |...|:.|:....:.....||||..:|::||.||...| ........:.:|:..
Mouse     4 SGLLLVAAVAFLSVLVLMSVWKQRKLSGKLPPGPTPLPFVGNFLQLNTE-QMYNSLMKISQRYGP 67

  Fly    65 DFRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRTMGTRKGITCTDGQLWY 127
            .|.     :.||...:||..|.|.|||  |...|.|.||.:.........|  .||..:.|:...
Mouse    68 VFT-----IYLGSRRIVVLCGQETVKEALVDQAEEFSGRGEQATFDWLFKG--YGIAFSSGERAK 125

  Fly   128 EHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKR 192
            :.|.|::..:|:.|.|:..:|..|:.||..|:....:|....|:|..:|:::|.||:..::.|.|
Mouse   126 QLRRFSITTLRDFGVGKRGIEERIQEEAGFLIDSFRKTNGAFIDPTFYLSRTVSNVISSIVFGDR 190

  Fly   193 IARQEDGTLRRLLDLM--------NRRSKLFDICGGLLAQFPWLRHVAPDRTGYNLIQQLNTELY 249
            . ..||.....||.:|        ....:::::...::...|     .|.:..:..:|.|.
Mouse   191 F-DYEDKEFLSLLRMMLGSLQFTATSMGQVYEMFSSVMKHLP-----GPQQQAFKELQGLE---- 245

  Fly   250 GFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTT 314
            .|....:|.::|.|  ||: :..|.|.::|..|.:... ..::.|....||:|.|:.|.||::|.
Mouse   246 DFITKKVEHNQRTL--DPN-SPRDFIDSFLIRMLEEKK-NPNTEFYMKNLVLTTLNLFFAGTETV 306

  Fly   315 SNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPI 379
            |.|:....::|...||::.|:..::...:   ..:..|....|....|.:|.|.|:|||..:.|:
Mouse   307 STTLRYGFLLLMKYPDIEAKVHEEIDRVI---GRNRQPKYEDRMKMPYTEAVIHEIQRFADLIPM 368

  Fly   380 TGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFG 444
            ...||....||...:.:||...:...|.||..|.:.:.:|.:|.|:.|:|..|:..|.:.|:||.
Mouse   369 GLARRVTKDTKFRDFLLPKGTEVFPMLGSVLKDPKFFSNPKDFNPKHFLDDKGQFKKSDAFVPFS 433

  Fly   445 MGRRRCLGDALARACIFSFLVRIVQHF---SVVLP--AGESPSMVLLPGITLTPKPYKVQFVKR 503
            :|:|.|.|:.|||..:|.||..|:|:|   |...|  ...||.:|   |....|..|.:.|:.|
Mouse   434 IGKRYCFGEGLARMELFLFLTNIMQNFHFKSTQEPQDIDVSPRLV---GFVTIPPTYTMSFLSR 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	CYP15A1-like	68..498	CDD:410744	122/444 (27%)
Cyp2a4	NP_034127.2	CYP2A	65..489	CDD:410761	123/450 (27%)