Protein Alignment Cyp305a1 and CYP2U1

DIOPT Version :9

• Sequence 1: NP_649151.1
• Gene: Cyp305a1 / 40161
• FlyBaseID: FBgn0036910
• Length: 504
• Species: Drosophila melanogaster
• Sequence 2: XP_005262774.1
• Gene: CYP2U1 / 113612
• HGNCID: 20582
• Length: 562
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 158/546 - (28%)
• Similarity: 263/546 - (48%)
• Gaps: 67/546 - (12%)

  Fly     5 IFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGN--------------TLQFRKEASAVG-- 53
            :.||. |:..:.:|.: ..||.:..||||...|.:||              .|..|..|:.:.
Human    37 LLLCG-LVALLGWSWL-RRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPS 99

  Fly    54 --GQHILFERWAKDFRSDLVGLKLGREYVVVALGHEMVKE--VQLQEVFEGRPDNFFLRLRT--M 112
              |..:|....|:.:.| :....:|...|||......|:|  ||..|||..||....:.:.|  .
Human   100 VIGPQVLLAHLARVYGS-IFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEK 163

  Fly   113 GTRKGITC-----TD----------GQLWYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQL 162
            |.|:.:.|     .|          |.:|.:.|.|:...:|:.|.|:..:|..|..|.:.:..::
Human   164 GEREVVGCGYADAADESPGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEM 228

  Fly   163 ERTEEQPIEPVTWLAQSVLNVLWCLIAGKRI------ARQEDGTLRRLLDL-MNRRSKLFDICGG 220
            ::..|.|..|.:.::.:|.|::..|..|:|.      .::..|.:.|.|:: :|.:..|.:||
Human   229 QKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNIC-- 291

  Fly   221 LLAQFPWLRHV--APDRTGYNLIQQLNTELYGFFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMK 283
                 |||.::  .|    :..::|:..::..|....|::|:..|.:: :|  .|.|..||..|:
Human   292 -----PWLYYLPFGP----FKELRQIEKDITSFLKKIIKDHQESLDRE-NP--QDFIDMYLLHME 344

  Fly   284 DRSAGGESSTFNETQLVMTILDFFIAGSQTTSNTINLALMVLAMRPDVQEKLFSQVTASVAAAST 348
            :......:|:|:|..|...|.|.||||:.||:|::...|:.:::.||||||:..::...:.|
Human   345 EERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGA--- 406

  Fly   349 DAFPHLSRREAFDYMDAFIMEVQRFFHITPITGPRRALWATKLGGYDIPKNATILISLRSVHLDK 413
            :..|.|:.:....|.:|.||||||...:.|:..|......|.|.||.|||...||.:|.|||.|.
Human   407 NRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDP 471

  Fly   414 EHWKDPLEFRPERFIDSAGKCFKDEYFMPFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPA- 477
            ..|:.|.:|.|.||:|..|:..|.|.|:|||:|:|.|:|:.||:..:|...|.::|.|:..||.
Human   472 AIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPED 536

  Fly   478 GESPSMVLLPGITLTPKPYKVQFVKR 503
            .:.|.:....|:||.|.|:.:...:|
Human   537 SKKPLLTGRFGLTLAPHPFNITISRR 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	151/516 (29%)
CYP2U1	XP_005262774.1	p450	60..555	CDD:278495	150/512 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.920