DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and cyp2aa7

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001103192.1	Gene:	cyp2aa7 / 101882126	ZFINID:	ZDB-GENE-071004-48	Length:	499	Species:	Danio rerio

Alignment Length:	511	Identity:	155/511 - (30%)
Similarity:	247/511 - (48%)	Gaps:	57/511 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLG-------NTLQFRKEASAVGGQHILFER 61
            |||    |:.|.|:.:.|...|   |||||..:|::|       |.::|.:.....|
Zfish    21 LIF----LVLFEIFRINSYKGR---FPPGPTPLPFVGNLPHSLKNPMEFIRSMPQYG-------- 70

  Fly    62 WAKDFRSDLVGLKLGREYVVVALGHEMVKEVQLQEVFEGRPDNFFLRLRTMGTRKG-ITCTDGQL 125
                   ::..:.|||...:|....::.||..:|:.|.|||  |...:..:....| |..|....
Zfish    71 -------EMTTMYLGRRPAIVLNTIQLAKEAFVQDAFSGRP--FLPVMDWVANGLGIIMVTFNHS 126

  Fly   126 WYEHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAG 190
            |.:.|.||:..:||.|.|:..:|..:..|:..|:.::.:.|.:|:.|...:..:|.|::..::.|
Zfish   127 WRQQRRFALHTLRNFGLGKKSVEDRVLEESRYLIAEILKGEGKPMSPHHPIQNAVSNIICSIVFG 191

  Fly   191 KRIARQEDGTLRRLLDLMNRRSKLFDICGGLLAQF----PWLRHV-APDRTGYNLIQQLNTELYG 250
            .|. ..::.....||:|:|..   |.:.|....|.    |:::|. .|    :..|:|...||..
Zfish   192 DRF-DYDNKRFEYLLELLNEN---FVLTGSAAGQIFNLAPFIKHFPGP----HQKIKQNANELLA 248

  Fly   251 FFMDTIEEHRRQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQTTS 315
            |....::||::.|..| ||  .|.|.|||.|: ::....:.|||:|..|.::..|.|:||:.|||
Zfish   249 FIQGEVKEHKKTLDPD-SP--RDFIDAYLLEI-EKQKSNKDSTFHEGNLAISTADLFLAGTDTTS 309

  Fly   316 NTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLSRREAFDYMDAFIMEVQRFFHITPIT 380
            .||...|:.|...|||||:...::   |.....|..|.:..|:...|..|.:.|:||..::.|..
Zfish   310 TTIRWGLLFLTQNPDVQERCHEEI---VQVLGYDRLPSMDDRDKLPYTLATVHEIQRCANLVPFG 371

  Fly   381 GPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFMPFGM 445
            .....:..|||.|||||:...::.:|.::..||||||.|..|.||.|:|...:..|.|.|:||.:
Zfish   372 VIHETIQPTKLRGYDIPQGTVVMTNLAAILSDKEHWKHPDTFNPENFLDENRQFSKPESFIPFSL 436

  Fly   446 GRRRCLGDALARACIFSFLVRIVQ--HFSVVLPAGESP-SMVLLPGITLTPKPYKV 498
            |.|.|||:.||:..:|.|:..::|  |||  .|....| .|..:.||...|:|:.:
Zfish   437 GLRFCLGETLAKMELFLFITSLLQRIHFS--SPPDAKPIDMDGVVGIVRYPQPFSI 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	146/485 (30%)
cyp2aa7	NP_001103192.1	p450	40..491	CDD:278495	146/485 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000008
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	4.010