DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp305a1 and LOC100148115

DIOPT Version :9

Sequence 1:	NP_649151.1	Gene:	Cyp305a1 / 40161	FlyBaseID:	FBgn0036910	Length:	504	Species:	Drosophila melanogaster
Sequence 2:	NP_001315620.1	Gene:	LOC100148115 / 100148115	-ID:	-	Length:	496	Species:	Danio rerio

Alignment Length:	513	Identity:	165/513 - (32%)
Similarity:	263/513 - (51%)	Gaps:	48/513 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSALIFLCAILIGFVIYSLISSARRPKNFPPGPRFVPWLGNTLQFRKEASAVGGQHILFERWAKD 65
            ::||:.||  |..|::| |....||||||||||..||..||.||..:.:....     |:::|:.
Zfish     2 LTALVLLC--LGAFLLY-LQLRIRRPKNFPPGPAPVPIFGNLLQLNRISPLKD-----FDKFAQH 58

  Fly    66 FRSDLVGLKLGREYVVVALGHEMVKEVQLQEV--FEGRPDNFFLRLRTMGTRKGITCTD-GQLWY 127
            :.| :.|:.:|.:..||..|.:|:||..:.:.  |.||.:|......|.|  ||:...| |:.|.
Zfish    59 YGS-IYGIYIGSQPAVVLTGQKMIKEALITQAAEFSGRSNNMMFSHVTGG--KGVIMADYGESWR 120

  Fly   128 EHRHFAMKQMRNVGYGRSQMEHHIELEAEELLGQLERTEEQPIEPVTWLAQSVLNVLWCLIAGKR 192
            |||.||:..:||.|.|:..||..|..|.:.:...||.:..:.|:|.....|:..|::..:|.|.|
Zfish   121 EHRRFALTTLRNFGLGKKSMEQRILEEVKHICLLLEESAGKSIDPQHLYHQAASNIIASIIFGSR 185

  Fly   193 IARQEDGTLRRLLDLMNRRSK--------LFDICGGLLAQFPWLRHVAPDRTGYNLIQQLNTELY 249
            . ..:|...:.|:..:...:|        |::| ..:|..||     .|.:..:...:|:...:
Zfish   186 F-NYKDAYFQTLITSVEDLTKITIGPWAMLYEI-APVLRIFP-----LPFQKAFQYFEQITKHV- 242

  Fly   250 GFFMDTIEEHR-RQLAKDPSPAESDLIYAYLQEMKDRSAGGESSTFNETQLVMTILDFFIAGSQT 313
               :..:|||: .::|.:|    .|||..||:||:::|  ...::|:|:|:|..:.|.||||::|
Zfish   243 ---LKVVEEHKTSRVAGEP----RDLIDCYLEEMENKS--DHRTSFDESQMVTLLFDLFIAGTET 298

  Fly   314 TSNTINLALMVLAMRPDVQEKLFSQVTASVAAASTDAFPHLS--RREAFDYMDAFIMEVQRFFHI 376
            ||||:....:.|.....:||:...::...:.|..     |::  .|.|..::.|.|.|.||...|
Zfish   299 TSNTLRTLTLYLMTYTHIQEQCQREIDEVLGARD-----HVTYEDRNAMHFVQAVIHEGQRVADI 358

  Fly   377 TPITGPRRALWATKLGGYDIPKNATILISLRSVHLDKEHWKDPLEFRPERFIDSAGKCFKDEYFM 441
            .|::....|...|:|.||.|||...|:..|.|...::..||.|.||.|:.|::..|:..|::.||
Zfish   359 APLSMFHSAKTDTQLRGYSIPKGTIIIPYLSSSLREESQWKFPHEFNPQNFLNEKGEFVKNDAFM 423

  Fly   442 PFGMGRRRCLGDALARACIFSFLVRIVQHFSVVLPAGE-SPSMVLLPGITLTPKPYKV 498
            ||..|.|.|||:.|||..:|..||.:::.|.:|.|..| .|....:.|.|.:.|||:|
Zfish   424 PFSAGPRVCLGENLARMELFLILVTVLRRFRLVWPKDEGEPDFTYIYGGTQSVKPYRV 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp305a1	NP_649151.1	p450	30..500	CDD:278495	151/484 (31%)
LOC100148115	NP_001315620.1	p450	28..483	CDD:278495	151/484 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45226
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3475
SonicParanoid	1	1.000	-	-		X6
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.950