DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kap-alpha1 and SPAG6

DIOPT Version :9

Sequence 1:	NP_524167.1	Gene:	Kap-alpha1 / 40160	FlyBaseID:	FBgn0024889	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_036575.1	Gene:	SPAG6 / 9576	HGNCID:	11215	Length:	509	Species:	Homo sapiens

Alignment Length:	499	Identity:	94/499 - (18%)
Similarity:	191/499 - (38%)	Gaps:	104/499 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 MADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEEVIQKG 137
            :|:.:|..||.|...:....|::...::.::.:.::...|...:     |:...:...|.|::..
Human    24 VAELATRPQNIETLQNAGVMSLLRTLLLDVVPTIQQTAALALGR-----LANYNDDLAEAVVKCD 83

  Fly   138 IVPQFV-------TFLRNSANATLQ----------------------------FE------AAWT 161
            |:||.|       .|.:.:|...|:                            |:      |||.
Human    84 ILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAAAWA 148

  Fly   162 LTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQEQAVWALGNIAGDSPMCRDHLLGSGILEP 226
            |..||...::.::.|::|||||:.:..:..|...::..|..||.:||..||.....::.:|.:..
Human   149 LRYIARHNAELSQAVVDAGAVPLLVLCIQEPEIALKRIAASALSDIAKHSPELAQTVVDAGAVAH 213

  Fly   227 LLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKI---SHGLPILARLLKYTDADVLSDTCWA 288
            |..::.|.|  ..:::.:  ||.|.:......|.|::   :...|::...||..|..|..:....
Human   214 LAQMILNPD--AKLKHQI--LSALSQVSKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNASTL 274

  Fly   289 IGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAALRAVGNIVTGDDQQTQVIL---GYNA 350
            |..::....:..|.|::||....:::.:...:.|.....:..:|.:....:.....::   |...
Human   275 IREIAKHTPELSQLVVNAGGVAAVIDCIGSCKGNTRLPGIMMLGYVAAHSENLAMAVIISKGVPQ 339

  Fly   351 LT-CISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIFPQLMVIMQTAE------FKTR 408
            |: |:|   ....:.||..:.|.:..|.....|..:|:...|..|.|:.:..:.|      .|::
Human   340 LSVCLS---EEPEDHIKAAAAWALGQIGRHTPEHARAVAVTNTLPVLLSLYMSTESSEDLQVKSK 401

  Fly   409 KEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNALENIL----KAGEKFQ 469
            |    ||.|.....|:           :|.:..||.....:|::..:.....:|    ||...|.
Human   402 K----AIKNILQKCTY-----------LPALEPFLYDAPPNILKHVVGQFSKVLPHDSKARRLFV 451

  Fly   470 TRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGN 513
            |           .|||.|::.::|....        ::::|..:
Human   452 T-----------SGGLKKVQEIKAEPGS--------LLQEYINS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	94/499 (19%)
		IBB	3..116	CDD:280005	7/42 (17%)
		ARM	131..252	CDD:237987	37/161 (23%)
		armadillo repeat	133..165	CDD:293788	13/72 (18%)
		armadillo repeat	173..209	CDD:293788	11/35 (31%)
		armadillo repeat	215..250	CDD:293788	6/34 (18%)
		ARM	264..378	CDD:237987	20/117 (17%)
		armadillo repeat	267..292	CDD:293788	6/24 (25%)
		armadillo repeat	300..336	CDD:293788	6/35 (17%)
		armadillo repeat	342..376	CDD:293788	7/37 (19%)
		ARM	356..461	CDD:237987	20/110 (18%)
		armadillo repeat	384..421	CDD:293788	10/42 (24%)
		armadillo repeat	427..461	CDD:293788	4/33 (12%)
		Arm_3	473..517	CDD:292804	6/41 (15%)
SPAG6	NP_036575.1	ARM 1	31..70		6/43 (14%)
		armadillo repeat	37..68	CDD:293788	2/35 (6%)
		ARM 2	73..112		9/38 (24%)
		armadillo repeat	78..110	CDD:293788	8/31 (26%)
		SRP1	112..>423	CDD:227396	65/332 (20%)
		ARM 3	115..154		6/38 (16%)
		armadillo repeat	120..152	CDD:293788	5/31 (16%)
		ARM 4	157..196		11/38 (29%)
		armadillo repeat	160..196	CDD:293788	11/35 (31%)
		ARM 5	199..238		8/42 (19%)
		armadillo repeat	202..234	CDD:293788	6/35 (17%)
		ARM 6	241..280		8/38 (21%)
		armadillo repeat	244..278	CDD:293788	7/33 (21%)
		HEAT repeat	289..325	CDD:293787	5/35 (14%)
		ARM 7	325..365		8/42 (19%)
		HEAT repeat	335..369	CDD:293787	8/36 (22%)
		ARM 8	368..409		11/44 (25%)
		HEAT repeat	378..406	CDD:293787	8/31 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810