Protein Alignment Kap-alpha1 and SRP1

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_014210.1
• Gene: SRP1 / 855532
• SGDID: S000005133
• Length: 542
• Species: Saccharomyces cerevisiae
• Alignment Length: 546
• Identity: 264/546 - (48%)
• Similarity: 349/546 - (63%)
• Gaps: 40/546 - (7%)

  Fly     6 KQRYKN-AALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQQAA 69
            :..:|| ....:.|:||||:...::|||.||::.|.||||.:  |.|.    |.:|:.::|...:
Yeast    18 RTNFKNKGRFSADELRRRRDTQQVELRKAKRDEALAKRRNFI--PPTD----GADSDEEDESSVS 76

  Fly    70 DMHMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEEVI 134
                ||.....|.::..          .:|.|.|.|....|||.||.|||::|||:..|||:.||
Yeast    77 ----ADQQFYSQLQQEL----------PQMTQQLNSDDMQEQLSATVKFRQILSREHRPPIDVVI 127

  Fly   135 QKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQEQ 199
            |.|:||:.|.|:|.:....||.||||.|||||||||.|||||::|.|||:||.||.:...:|:||
Yeast   128 QAGVVPRLVEFMRENQPEMLQLEAAWALTNIASGTSAQTKVVVDADAVPLFIQLLYTGSVEVKEQ 192

  Fly   200 AVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKIS 264
            |:|||||:||||...||::|....:||:|. |.||::.::||.|.||||||||||.|..|::.:|
Yeast   193 AIWALGNVAGDSTDYRDYVLQCNAMEPILG-LFNSNKPSLIRTATWTLSNLCRGKKPQPDWSVVS 256

  Fly   265 HGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAALR 329
            ..||.||:|:...|.:.|.|.||||.||||||.:.||||||..:.:||||||.|....|.|.|||
Yeast   257 QALPTLAKLIYSMDTETLVDACWAISYLSDGPQEAIQAVIDVRIPKRLVELLSHESTLVQTPALR 321

  Fly   330 AVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIFP 394
            ||||||||:|.||||::....|..:..||.|..|.||||:|||||||.|||.|||||:|:||:.|
Yeast   322 AVGNIVTGNDLQTQVVINAGVLPALRLLLSSPKENIKKEACWTISNITAGNTEQIQAVIDANLIP 386

  Fly   395 QLMVIMQTAEFKTRKEAAWAITNATSSGTH--EQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNA 457
            .|:.:::.||:||:|||.|||:||:|.|..  :.|.|||..||:.|:||.|.:.|:.|::|.|:|
Yeast   387 PLVKLLEVAEYKTKKEACWAISNASSGGLQRPDIIRYLVSQGCIKPLCDLLEIADNRIIEVTLDA 451

  Fly   458 LENILKAGEKFQ----TRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNEEE-- 516
            ||||||.||..:    ...|..|..||:.||::||...|.:||..||.|::.|||.|||.||:
Yeast   452 LENILKMGEADKEARGLNINENADFIEKAGGMEKIFNCQQNENDKIYEKAYKIIETYFGEEEDAV 516

  Fly   517 DSRVAPV-AG---------TQQFEFD 532
            |..:||. ||         .|||.|:
Yeast   517 DETMAPQNAGNTFGFGSNVNQQFNFN 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	264/546 (48%)
		armadillo repeat	133..165	CDD:293788	17/31 (55%)
		armadillo repeat	173..209	CDD:293788	21/35 (60%)
		armadillo repeat	215..250	CDD:293788	16/34 (47%)
		armadillo repeat	267..292	CDD:293788	12/24 (50%)
		armadillo repeat	300..336	CDD:293788	23/35 (66%)
		armadillo repeat	342..376	CDD:293788	17/33 (52%)
		armadillo repeat	384..421	CDD:293788	20/36 (56%)
		armadillo repeat	427..461	CDD:293788	17/33 (52%)
SRP1	NP_014210.1	SRP1	8..542	CDD:227396	263/544 (48%)
		armadillo repeat	89..114	CDD:293788	12/34 (35%)
		armadillo repeat	125..158	CDD:293788	17/32 (53%)
		armadillo repeat	166..202	CDD:293788	21/35 (60%)
		armadillo repeat	208..242	CDD:293788	16/34 (47%)
		armadillo repeat	259..284	CDD:293788	12/24 (50%)
		armadillo repeat	294..326	CDD:293788	19/31 (61%)
		armadillo repeat	334..370	CDD:293788	19/35 (54%)
		armadillo repeat	376..409	CDD:293788	18/32 (56%)
		armadillo repeat	421..455	CDD:293788	17/33 (52%)