DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kap-alpha1 and IMPA-9

DIOPT Version :9

Sequence 1:	NP_524167.1	Gene:	Kap-alpha1 / 40160	FlyBaseID:	FBgn0024889	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_195927.2	Gene:	IMPA-9 / 831675	AraportID:	AT5G03070	Length:	519	Species:	Arabidopsis thaliana

Alignment Length:	541	Identity:	149/541 - (27%)
Similarity:	257/541 - (47%)	Gaps:	60/541 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SASHKQRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQ 66
            |||:::....:::.:...:|||:: .:.:.|.:||..:..:|           ...|.:|.|.|.
plant     6 SASNRRDPIKSSVGNVAGQRRRKQ-AVTVAKERRELLVRAKR-----------LCRVGTNGDVED 58

  Fly    67 QAADMHMADSSTGGQNEEAAGSGAQPSVINEEM---IQMLFSGRENEQLEATQKFRKLLSRDPNP 128
            ...:..|.      .:||.....||.|...||:   :|....|...:::.|.::.|:|||:...|
plant    59 ALVENEMM------VDEEQPILEAQASKSVEELKSAVQYQGKGAMQKRVTALRELRRLLSKSEFP 117

  Fly   129 PIEEVIQKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLL---- 189
            |:|..::.|.:|..|..|...:......|:||.|||||:|..::||.::.  |:|:.|..|
plant   118 PVEAALRAGAIPLLVQCLSFGSPDEQLLESAWCLTNIAAGKPEETKALLP--ALPLLIAHLGEKS 180

  Fly   190 SSPHDDVQEQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRG- 253
            |:|   |.||..||:||:||:....|:.||..|.|.||..::. .|:.:.:|.|.|.||||.:|
plant   181 SAP---VAEQCAWAIGNVAGEGEDLRNVLLSQGALPPLARMIF-PDKGSTVRTAAWALSNLIKGP 241

  Fly   254 -KSPPADFAKISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVE-LL 316
             ....|...||...|..:.|.||.||.:..::..|.|.|||...:.....::..|:.:.|:: |.
plant   242 ESKAAAQLVKIDGILDAILRHLKKTDEETATEIAWIIVYLSALSDIATSMLLKGGILQLLIDRLA 306

  Fly   317 LHPQQNVSTAALRAVGNIVTGDDQQTQVIL------GYNALTCISHLLHSTAETIKKESCWTISN 375
            ......:....||::||.|..|.:....||      ..:.:..::..|.|....:|||:.|.:||
plant   307 TSSSLQLLIPVLRSLGNFVAVDPKAVLTILIREQNTEESIIGVLAKCLRSEHRVLKKEAAWVLSN 371

  Fly   376 IAAGNREQIQALINANIFPQLMVIMQTAEFKTRKEAAWAITN---ATSSG------THEQIHYLV 431
            ||||:.|..:.:.:..:.|.|:.|:.|:.|..|||.|:.:.|   .::.|      ..|.:..:|
plant   372 IAAGSIEHKRMIHSTEVMPLLLRILSTSPFDIRKEVAYVLGNLCVESAEGDRKPRIIQEHLVSIV 436

  Fly   432 QVGCVPPMCDFLTVVDSDIVQVALNALENILKAGEKFQTRPN---PYAITIEECGGLDKIEYLQA 493
            ..||:....:.:...|.:..::.|..:|.:|:.      .||   |..:..|:  |:|.:|..|.
plant   437 SGGCLRGFIELVRSPDIEAARLGLQFIELVLRG------MPNGEGPKLVEGED--GIDAMERFQF 493

  Fly   494 HENRDIYHKSFYIIEQYFGNE 514
            |||.::...:..::::|||.:
plant   494 HENEELRVMANSLVDKYFGED 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	149/541 (28%)
		IBB	3..116	CDD:280005	24/115 (21%)
		ARM	131..252	CDD:237987	46/124 (37%)
		armadillo repeat	133..165	CDD:293788	9/31 (29%)
		armadillo repeat	173..209	CDD:293788	15/39 (38%)
		armadillo repeat	215..250	CDD:293788	13/34 (38%)
		ARM	264..378	CDD:237987	31/120 (26%)
		armadillo repeat	267..292	CDD:293788	8/24 (33%)
		armadillo repeat	300..336	CDD:293788	7/36 (19%)
		armadillo repeat	342..376	CDD:293788	9/39 (23%)
		ARM	356..461	CDD:237987	31/113 (27%)
		armadillo repeat	384..421	CDD:293788	10/39 (26%)
		armadillo repeat	427..461	CDD:293788	6/33 (18%)
		Arm_3	473..517	CDD:292804	13/45 (29%)
IMPA-9	NP_195927.2	SRP1	24..519	CDD:227396	146/523 (28%)
		ARM	120..238	CDD:237987	45/123 (37%)
		armadillo repeat	121..154	CDD:293788	9/32 (28%)
		armadillo repeat	162..197	CDD:293788	15/39 (38%)
		armadillo repeat	203..237	CDD:293788	13/34 (38%)
		ARM	205..326	CDD:237987	36/121 (30%)
		armadillo repeat	247..283	CDD:293788	13/35 (37%)
		armadillo repeat	289..323	CDD:293788	5/33 (15%)
		armadillo repeat	342..372	CDD:293788	7/29 (24%)
		ARM	343..454	CDD:237987	29/110 (26%)
		armadillo repeat	380..422	CDD:293788	10/41 (24%)
		Arm_3	478..519	CDD:292804	11/39 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23316
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910