Protein Alignment Kap-alpha1 and kpna1

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: XP_701359.6
• Gene: kpna1 / 572542
• ZFINID: ZDB-GENE-091116-39
• Length: 596
• Species: Danio rerio
• Alignment Length: 546
• Identity: 323/546 - (59%)
• Similarity: 397/546 - (72%)
• Gaps: 35/546 - (6%)

  Fly     9 YKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNV-------VLEPATSSTSAGVESNTDNEQ 66
            |||.:|::.||||||||.|:||||.|:::||||||||       .||....|.|..:||..:|
Zfish    71 YKNKSLNTDEMRRRREEEGLQLRKQKKDEQLFKRRNVATVEEDGALEDDGMSDSGYLESQANN-- 133

  Fly    67 QAADMHMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIE 131
                   .|..||             |||:|:||||:||....:||..||:||||||::|||||:
Zfish   134 -------MDQITG-------------SVISEDMIQMIFSSSPEQQLIGTQRFRKLLSKEPNPPID 178

  Fly   132 EVI-QKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDD 195
            ||| ..|:|.:||.||:...|.||||||||.|||||||||.||:|||:||||||||::|||..:|
Zfish   179 EVIATPGVVERFVEFLKRRENCTLQFEAAWVLTNIASGTSHQTRVVIQAGAVPIFIEMLSSDFED 243

  Fly   196 VQEQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADF 260
            ||||||||||||||||..|||::|...||..|:.:|:..:|:||:|||||.||||||||:||.||
Zfish   244 VQEQAVWALGNIAGDSTECRDYVLDCNILPSLVQLLAKQNRLTMMRNAVWALSNLCRGKNPPPDF 308

  Fly   261 AKISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVST 325
            ||:|..|.:|:.||...|.|:|:|.|||:.|||||||:|||||||:||||||||||||.:..|.:
Zfish   309 AKVSPCLSVLSWLLFVNDTDILADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLLHAEYKVVS 373

  Fly   326 AALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINA 390
            .|||||||||||||.||||||..:||..:.|||.|..|:||||:|||||||.||||.|||.:|:|
Zfish   374 PALRAVGNIVTGDDLQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQMVIDA 438

  Fly   391 NIFPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVAL 455
            ::||.|:.|:|.|||:||||||||||||||.|:.|||.:||::||:.|:||.||::||.||||||
Zfish   439 DLFPPLISILQVAEFRTRKEAAWAITNATSGGSAEQIRHLVELGCIKPLCDLLTLMDSKIVQVAL 503

  Fly   456 NALENILKAGEKFQTRP---NPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNEEED 517
            |.|||||:.||....|.   |||...|||..||||:|:||.|||::||.|:|.:||:||..::||
Zfish   504 NGLENILRLGELEAKRGGGINPYCALIEEAYGLDKLEFLQGHENQEIYQKAFDLIERYFSTDDED 568

  Fly   518 SRVAPVAG--TQQFEFDPDNMPSTGF 541
            ..:||...  .|||.|.....|..||
Zfish   569 PSLAPAVDLQQQQFLFQQCEAPMEGF 594

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	323/546 (59%)
		armadillo repeat	133..165	CDD:293788	19/32 (59%)
		armadillo repeat	173..209	CDD:293788	28/35 (80%)
		armadillo repeat	215..250	CDD:293788	17/34 (50%)
		armadillo repeat	267..292	CDD:293788	11/24 (46%)
		armadillo repeat	300..336	CDD:293788	27/35 (77%)
		armadillo repeat	342..376	CDD:293788	21/33 (64%)
		armadillo repeat	384..421	CDD:293788	25/36 (69%)
		armadillo repeat	427..461	CDD:293788	21/33 (64%)
kpna1	XP_701359.6	SRP1	66..573	CDD:227396	314/523 (60%)
		armadillo repeat	187..213	CDD:293788	16/25 (64%)
		armadillo repeat	221..257	CDD:293788	28/35 (80%)
		armadillo repeat	263..298	CDD:293788	17/34 (50%)
		armadillo repeat	315..340	CDD:293788	11/24 (46%)
		armadillo repeat	348..384	CDD:293788	27/35 (77%)
		armadillo repeat	390..424	CDD:293788	21/33 (64%)
		armadillo repeat	432..468	CDD:293788	24/35 (69%)
		armadillo repeat	475..509	CDD:293788	21/33 (64%)