Protein Alignment Kap-alpha1 and tmco6

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001083006.1
• Gene: tmco6 / 559069
• ZFINID: ZDB-GENE-070410-47
• Length: 504
• Species: Danio rerio
• Alignment Length: 544
• Identity: 118/544 - (21%)
• Similarity: 223/544 - (40%)
• Gaps: 96/544 - (17%)

  Fly    12 AALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQQAADMHMADS 76
            :|.|..|.:|:|.|....||:.::::||..:|.             ::::.:.|::..:..|...
Zfish    14 SASDLEEFKRKRREFEKALRQARKDRQLVSKRL-------------LQNDVEEEEKEEEESMETC 65

  Fly    77 STGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEEVIQKGIVPQ 141
            .|...:|:.           :|||:.:..|.| |:.......||.| |:|...:..:..:..:..
Zfish    66 FTFLSSEQV-----------KEMIRGVQMGGE-EKAARLASLRKAL-RNPENQLAFIKSENSMHM 117

  Fly   142 FVTFLRNSANATLQFEAAWTLTNIA-SGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQEQAVWALG 205
            .:..| ::.||..|.||...|..:: |.....::..:.||  |..:..|||....:.|..::.||
Zfish   118 LIGQL-SAHNAQCQLEATRCLHQLSHSSHPSVSQACVPAG--PYLLTYLSSQSTQLTEVCLYTLG 179

  Fly   206 NIAGDSPMCRDHLLGSGILEPLLHVLSNSD-RITMIRNAVWTLSNLCRGKSP-----PADFAK-- 262
            |:..|:...|:.||..||:..|.:.:.|.. .:.::....:|||.|.:.|..     ||..|.
Zfish   180 NLCPDNAAVREKLLAQGIVSALANCIHNQRYNLAVVEAFGFTLSQLLQAKDATEKIIPAVMASGI 244

  Fly   263 ISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAA 327
            :.|.:..|....::.....: :..|.:.||       :.:.:|..:      |:.|...:..:|.
Zfish   245 VPHLISALTPDPEFGFGPAI-ECSWCLHYL-------VSSSLDNSM------LIAHGALSHCSAV 295

  Fly   328 LRAVGNIVT-GDDQQTQVILGYNALTCISHLLHSTAETI------------------------KK 367
            |.|:|..|. |:.|....:|.:..|.|:.:||.|..:.|                        .:
Zfish   296 LIALGGAVAKGNPQDGLELLIWPLLRCLGNLLASGGDVIPEDTRLLAALCVFAQIYLHLHPALSR 360

  Fly   368 ESCWTISNIAAGNREQIQALINANIFPQLMVIMQTAEFK--TRKEAAWAITNATSSGTHEQIHYL 430
            ||.||::|:.||:......|:..|:.|   :::|...|.  ....|...:.|....|. |....|
Zfish   361 ESLWTLNNLTAGSSGFCSGLLLLNMVP---ILIQFLSFSGGINSMALRVLGNIAHHGP-EYCVGL 421

  Fly   431 VQVGCVPPMCDFLTVVDSDIVQVALNALENILKAGEKFQTRPNPYAITIEE---CGGLDKIEYLQ 492
            .|.|.:..:|..|.:.|.::|.::|..|..::.:        ||..  :||   ..|:..:|.:|
Zfish   422 TQAGLLSALCATLKMADPEVVTLSLEVLYMLVSS--------NPQG--VEEFTRLNGIPLLEAIQ 476

  Fly   493 AHENRDIYHKSFYIIEQYFGNEEE 516
            .:...:...::.||::.:|.:..|
Zfish   477 YNNEGEQRVRAAYILDHHFPSFSE 500

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	118/544 (22%)
		armadillo repeat	133..165	CDD:293788	7/31 (23%)
		armadillo repeat	173..209	CDD:293788	10/35 (29%)
		armadillo repeat	215..250	CDD:293788	10/35 (29%)
		armadillo repeat	267..292	CDD:293788	2/24 (8%)
		armadillo repeat	300..336	CDD:293788	7/35 (20%)
		armadillo repeat	342..376	CDD:293788	11/57 (19%)
		armadillo repeat	384..421	CDD:293788	7/38 (18%)
		armadillo repeat	427..461	CDD:293788	9/33 (27%)
tmco6	NP_001083006.1	SRP1	19..504	CDD:227396	116/539 (22%)
		armadillo repeat	145..183	CDD:293788	10/39 (26%)
		armadillo repeat	339..369	CDD:293788	4/29 (14%)
		armadillo repeat	377..412	CDD:293788	7/37 (19%)
		armadillo repeat	418..449	CDD:293788	8/30 (27%)