Protein Alignment Kap-alpha1 and TMCO6

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001287909.1
• Gene: TMCO6 / 55374
• HGNCID: 28814
• Length: 499
• Species: Homo sapiens
• Alignment Length: 554
• Identity: 132/554 - (23%)
• Similarity: 211/554 - (38%)
• Gaps: 135/554 - (24%)

  Fly    18 EMRRRREEVGIQLRKNKREQQLFKR---RNVVLEPATSSTSAGVESNTDNEQQAADMHMADSSTG 79
            |:||||.|....|||.:|||||..:   ||...|.|.....|.:...|:.:|     .:..:..|
Human    18 ELRRRRREREAALRKARREQQLVSKRLLRNDAPEEAGEGCVAAILGETEVQQ-----FLRQAQRG 77

  Fly    80 GQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQK-FRKLLSRDPNPPIEEVIQKGIVPQFV 143
            .:.:|..|:              |.|.|...|...||: |.:|              :|.:...|
Human    78 TEEKEREGA--------------LVSLRRGLQHPETQQTFIRL--------------EGSMRTLV 114

  Fly   144 TFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEA--GAVPIFIDLLSSPHDDVQEQAVWALGN 206
            ..| .|..|.||.|||..|..: |.:.|.|  |.||  .|....:..|||...|..|..::.|||
Human   115 GLL-TSNQALLQLEAARCLHEL-SHSEQST--VAEACLPATSYLLTYLSSHSSDFIELCLYTLGN 175

  Fly   207 IAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKS------PPADFAKISH 265
            :..:|...|..||..||: |.|.....|..:.::....:.||.|.:.:.      |||     |.
Human   176 LIVESEAVRRQLLPQGIV-PALAACIQSPHVAVLEALGYALSQLLQAEEAPEKIIPPA-----SA 234

  Fly   266 GLPILARLLKY-----------TDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHP 319
            ...|||..|..           .:..|..:..|.:.|:               :|.::...||
Human   235 SSSILASTLPQHMLQMLQPGPKLNPGVAVEFAWCLHYI---------------ICSQVSNPLL-- 282

  Fly   320 QQNVSTAALRAVGNI---VTGDDQQTQ----VILGYNALTCISHLLHSTA-ETIKKESCWTISNI 376
               :...||..:|.:   :.|..|:|:    .:|....|.|:|:||...| ||:
Human   283 ---IGHGALSTLGLLLLDLAGAVQKTEDAGLELLACPVLRCLSNLLTEAAVETV----------- 333

  Fly   377 AAGNREQIQALINANIFPQLMVIMQTAEFKTRK------EAAWAITNATSSGTHEQIHYLVQVGC 435
              |.:.|::   :..:...|.:::|   |..:|      |..|.:.|.|:: :......|:.:..
Human   334 --GGQMQLR---DERVVAALFILLQ---FFFQKQPSLLPEGLWLLNNLTAN-SPSFCTSLLSLDL 389

  Fly   436 VPPMCDFLTVVDSDIVQV-ALNALENILKAGEKFQTR--PNPYAITIEECGGLDKIEYLQAHENR 497
            :.|:...|.|  |::|.| .|..|.|:.:.|..:..|  |.|.         |..:.:..|..:.
Human   390 IEPLLQLLPV--SNVVSVMVLTVLCNVAEKGPAYCQRLWPGPL---------LPALLHTLAFSDT 443

  Fly   498 DIYHKSFYIIEQYFGNEEEDSRV-APVAGTQQFE 530
            ::..:|..::...|..:.|..:| ...:|.|..|
Human   444 EVVGQSLELLHLLFLYQPEAVQVFLQQSGLQALE 477

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	132/554 (24%)
		armadillo repeat	133..165	CDD:293788	11/31 (35%)
		armadillo repeat	173..209	CDD:293788	13/37 (35%)
		armadillo repeat	215..250	CDD:293788	10/34 (29%)
		armadillo repeat	267..292	CDD:293788	6/35 (17%)
		armadillo repeat	300..336	CDD:293788	6/38 (16%)
		armadillo repeat	342..376	CDD:293788	10/38 (26%)
		armadillo repeat	384..421	CDD:293788	8/42 (19%)
		armadillo repeat	427..461	CDD:293788	9/34 (26%)
TMCO6	NP_001287909.1	SRP1	23..>399	CDD:227396	108/458 (24%)
		armadillo repeat	104..135	CDD:293788	12/45 (27%)
		armadillo repeat	143..178	CDD:293788	12/34 (35%)
		armadillo repeat	184..218	CDD:293788	10/34 (29%)