DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kap-alpha1 and Spag6l

DIOPT Version :9

Sequence 1:	NP_524167.1	Gene:	Kap-alpha1 / 40160	FlyBaseID:	FBgn0024889	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_056588.1	Gene:	Spag6l / 50525	MGIID:	1354388	Length:	507	Species:	Mus musculus

Alignment Length:	499	Identity:	93/499 - (18%)
Similarity:	191/499 - (38%)	Gaps:	104/499 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 MADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSR--DPNPPIEEVIQ 135
            :|:.:|..||.|...:....|::...::.::.:.::...|        .|.|  :.|..:.|.:.
Mouse    24 VAELATRPQNIETLQNAGVMSLLRPLLLDVVPTIQQTAAL--------ALGRLANYNDDLAEAVV 80

  Fly   136 KG-IVPQFV-------TFLRNSANATLQ----------------------------FE------A 158
            || |:||.|       .|.:.:|...|:                            |:      |
Mouse    81 KGDILPQLVYSLAEQNRFYKKAAAFVLRAVGKHSPQLAQAIVDCGALDTLVICLEDFDPGVKEAA 145

  Fly   159 AWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQEQAVWALGNIAGDSPMCRDHLLGSGI 223
            ||.|..||...::.::.|::|||:|:.:..:..|...::..|..||.:|:..||.....::.:|.
Mouse   146 AWALGYIARHNTELSQAVVDAGAIPLLVLCIQEPEIALKRIAASALSDISKHSPELAQTVVDAGA 210

  Fly   224 LEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKISHGLPILARLLKYTDADVLSDTCWA 288
            :..|..::.|.| ..:.|..:..||.:.:.....|:....:...|::...||..|..|..:.|..
Mouse   211 IAHLAQMILNPD-AKLKRQVLSALSQIAKHSVDLAEMVVEAEIFPVVLTCLKDKDEYVKKNACTL 274

  Fly   289 IGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAALRAVGNIVTGDDQQTQVIL---GYNA 350
            |..::....:..|.:::||....:::.:...:.|:....:..:|.:....:.....::   |...
Mouse   275 IREIAKHTPELSQLIVNAGGVAAVIDCIGSCKGNIRLPGIMMLGYVAAHSENLAMAVIISKGVPQ 339

  Fly   351 LT-CISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIFPQLMVIMQTAE------FKTR 408
            |: |:|   ....:.||..:.|.:..:.....|..:|:...|..|.|:.:..:.|      .|::
Mouse   340 LSICLS---EEPEDHIKAAAAWALGQLGRHTPEHARAVAVTNTLPVLLSLYMSPESSEDLQLKSK 401

  Fly   409 KEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNALENIL----KAGEKFQ 469
            |    ||.|.....|:           :|.:..||.....:|::..:.....:|    ||...|.
Mouse   402 K----AIKNILQKCTY-----------LPALEPFLYDAPPNILKHVVGQFSKVLPHDSKARRLFV 451

  Fly   470 TRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGN 513
            |           .|||.|::.::|....        ::::|..:
Mouse   452 T-----------SGGLKKVQEIKAEPGS--------LLQEYINS 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	93/499 (19%)
		IBB	3..116	CDD:280005	7/42 (17%)
		ARM	131..252	CDD:237987	36/162 (22%)
		armadillo repeat	133..165	CDD:293788	14/73 (19%)
		armadillo repeat	173..209	CDD:293788	10/35 (29%)
		armadillo repeat	215..250	CDD:293788	7/34 (21%)
		ARM	264..378	CDD:237987	19/117 (16%)
		armadillo repeat	267..292	CDD:293788	7/24 (29%)
		armadillo repeat	300..336	CDD:293788	5/35 (14%)
		armadillo repeat	342..376	CDD:293788	7/37 (19%)
		ARM	356..461	CDD:237987	19/110 (17%)
		armadillo repeat	384..421	CDD:293788	10/42 (24%)
		armadillo repeat	427..461	CDD:293788	4/33 (12%)
		Arm_3	473..517	CDD:292804	6/41 (15%)
Spag6l	NP_056588.1	ARM 1	31..70		7/46 (15%)
		SRP1	<34..183	CDD:227396	29/156 (19%)
		HEAT repeat	42..73	CDD:293787	4/38 (11%)
		ARM 2	73..112		10/38 (26%)
		HEAT repeat	85..109	CDD:293787	6/23 (26%)
		SRP1	112..>423	CDD:227396	61/329 (19%)
		ARM 3	115..154		6/38 (16%)
		armadillo repeat	120..152	CDD:293788	5/31 (16%)
		ARM 4	157..196		10/38 (26%)
		armadillo repeat	160..196	CDD:293788	10/35 (29%)
		ARM 5	199..238		8/39 (21%)
		armadillo repeat	202..236	CDD:293788	7/34 (21%)
		ARM 6	241..280		8/38 (21%)
		armadillo repeat	244..278	CDD:293788	8/33 (24%)
		ARM 7	325..365		7/42 (17%)
		armadillo repeat	328..360	CDD:293788	7/34 (21%)
		HEAT repeat	378..406	CDD:293787	8/31 (26%)
		ARM 8	402..441		9/53 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900