DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kap-alpha1 and kpna7

DIOPT Version :9

Sequence 1:	NP_524167.1	Gene:	Kap-alpha1 / 40160	FlyBaseID:	FBgn0024889	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_998235.1	Gene:	kpna7 / 406343	ZFINID:	ZDB-GENE-040426-2023	Length:	520	Species:	Danio rerio

Alignment Length:	537	Identity:	216/537 - (40%)
Similarity:	312/537 - (58%)	Gaps:	39/537 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSASHKQRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVES----- 60
            :|.....::||...:.|::|.||....::.||.:|.:.:.||||:        ||.|.|.
Zfish     6 LSDKRMSKFKNKGKEPTKLRDRRVAECVEFRKAQRVEGIMKRRNI--------TSLGDEEPLSPE 62

  Fly    61 -NTDNEQQAADMHMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSR 124
             ||||||...                        ...||::..:.:....:|....|..||||||
Zfish    63 FNTDNEQVIC------------------------TTIEEIVANVNTDCPEKQRNGCQAARKLLSR 103

  Fly   125 DPNPPIEEVIQKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLL 189
            :.|||::|:|:.|::.:||.||..:.:.||||||||:|||:|||||..|:.|:|.||||.||.||
Zfish   104 ERNPPLKEIIEAGLLTRFVEFLGRNDDPTLQFEAAWSLTNVASGTSWHTQQVVEHGAVPAFIALL 168

  Fly   190 SSPHDDVQEQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGK 254
            :||..::.|||||||||||||....||.|:..|::..||..|:....:..:||..||||||||.|
Zfish   169 ASPMLNISEQAVWALGNIAGDGSSYRDALIDCGVIPALLARLTPDAPVGYLRNLTWTLSNLCRNK 233

  Fly   255 SPPADFAKISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHP 319
            :|...|:.:...||.:.:||.::|..:|||.||||.||:||||::|..:|.||:..||||||...
Zfish   234 NPFPRFSAVQQMLPSIIQLLHHSDKSILSDACWAISYLTDGPNERIDVIIKAGILTRLVELLGFE 298

  Fly   320 QQNVSTAALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQI 384
            :..|.|.|||::.|||:|.|.|||..:....|:.:..|:.....:::||:.|.:||||||..:||
Zfish   299 ELAVVTPALRSIENIVSGSDLQTQAAIDAGVLSALPKLMRHQKSSVQKEAAWAVSNIAAGPCQQI 363

  Fly   385 QALINANIFPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSD 449
            |.||...:...|:.:::..:|||::||.||:||.||.||.||:.:||:.|.:..:.:.|.|.|:.
Zfish   364 QQLITCGLSAPLVDLLRNGDFKTQREAVWAVTNYTSGGTVEQVVHLVKCGALEAILNLLQVKDTK 428

  Fly   450 IVQVALNALENILKAGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNE 514
            .|.|.|:|:.||..|.||. ...:...:.:||.||||:||:.|.|||..:|..:..:||:||..:
Zfish   429 TVLVILDAISNIFLAAEKL-GEVDKLCLLVEEVGGLDRIEFFQNHENNAVYRAAQALIEKYFSED 492

  Fly   515 EEDSRVAPVAGTQQFEF 531
            .||..:...|....|.|
Zfish   493 GEDQCLTTEATDANFVF 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	216/537 (40%)
		IBB	3..116	CDD:280005	26/118 (22%)
		ARM	131..252	CDD:237987	64/120 (53%)
		armadillo repeat	133..165	CDD:293788	16/31 (52%)
		armadillo repeat	173..209	CDD:293788	23/35 (66%)
		armadillo repeat	215..250	CDD:293788	13/34 (38%)
		ARM	264..378	CDD:237987	49/113 (43%)
		armadillo repeat	267..292	CDD:293788	12/24 (50%)
		armadillo repeat	300..336	CDD:293788	17/35 (49%)
		armadillo repeat	342..376	CDD:293788	8/33 (24%)
		ARM	356..461	CDD:237987	41/104 (39%)
		armadillo repeat	384..421	CDD:293788	15/36 (42%)
		armadillo repeat	427..461	CDD:293788	10/33 (30%)
		Arm_3	473..517	CDD:292804	17/43 (40%)
kpna7	NP_998235.1	SRP1	1..520	CDD:227396	216/537 (40%)
		IBB	10..90	CDD:280005	25/111 (23%)
		ARM	111..231	CDD:237987	64/119 (54%)
		armadillo repeat	112..144	CDD:293788	16/31 (52%)
		armadillo repeat	152..188	CDD:293788	23/35 (66%)
		armadillo repeat	194..229	CDD:293788	13/34 (38%)
		ARM	246..357	CDD:237987	49/110 (45%)
		armadillo repeat	246..271	CDD:293788	12/24 (50%)
		armadillo repeat	279..315	CDD:293788	17/35 (49%)
		armadillo repeat	321..355	CDD:293788	8/33 (24%)
		ARM	322..441	CDD:237987	44/118 (37%)
		armadillo repeat	363..399	CDD:293788	14/35 (40%)
		armadillo repeat	406..440	CDD:293788	10/33 (30%)
		Arm_3	451..495	CDD:292804	17/43 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100442
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.730