DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Kap-alpha1 and KPNA2

DIOPT Version :9

Sequence 1:	NP_524167.1	Gene:	Kap-alpha1 / 40160	FlyBaseID:	FBgn0024889	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_001307540.1	Gene:	KPNA2 / 3838	HGNCID:	6395	Length:	529	Species:	Homo sapiens

Alignment Length:	552	Identity:	251/552 - (45%)
Similarity:	345/552 - (62%)	Gaps:	44/552 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ASHKQRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEP--ATSSTSAGVESNTDNE 65
            |:...|:||...|||||||||.||.::|||.|::.|:.|||||...|  |||.    ::.|.:|:
Human    11 AARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSP----LQENRNNQ 71

  Fly    66 QQAADMHMADSSTGGQNEEAAGSGAQPSVIN---EEMIQMLFSGRENEQLEATQKFRKLLSRDPN 127
                                       ..:|   :::::.:.|.....||:|||..||||||:..
Human    72 ---------------------------GTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQ 109

  Fly   128 PPIEEVIQKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSP 192
            |||:.:|:.|::|:||:||..:..:.:|||:||.|||||||||:|||.|::.||:|.||.||:||
Human   110 PPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASP 174

  Fly   193 HDDVQEQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITM----IRNAVWTLSNLCRG 253
            |..:.|||||||||||||..:.||.::..|.::|||.:|:..|..::    :||..||||||||.
Human   175 HAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRN 239

  Fly   254 KSPPADFAKISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLH 318
            |:|......:...||.|.|||.:.|.:||:||||||.||:||||::|..|:..||..:||:||..
Human   240 KNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGA 304

  Fly   319 PQQNVSTAALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQ 383
            .:..:.|.||||:||||||.|:||||::...||.....||.:....|:||:.||:|||.||.::|
Human   305 SELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQ 369

  Fly   384 IQALINANIFPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDS 448
            ||.::|..:.|.|:.::..|:|||:|||.||:||.||.||.|||.|||..|.:.|:.:.||..|:
Human   370 IQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDT 434

  Fly   449 DIVQVALNALENILKAGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFG- 512
            .|:.|.|:|:.||.:|.||. ......:|.|||||||||||.||.|||..:|..|..:||:||.
Human   435 KIILVILDAISNIFQAAEKL-GETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSV 498

  Fly   513 NEEEDSRVAPVAGTQQFEFD-PDNMPSTGFNF 543
            .||||..|.|...::.:.|. .|..|.| |||
Human   499 EEEEDQNVVPETTSEGYTFQVQDGAPGT-FNF 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	249/550 (45%)
		IBB	3..116	CDD:280005	36/117 (31%)
		ARM	131..252	CDD:237987	64/124 (52%)
		armadillo repeat	133..165	CDD:293788	14/31 (45%)
		armadillo repeat	173..209	CDD:293788	23/35 (66%)
		armadillo repeat	215..250	CDD:293788	14/38 (37%)
		ARM	264..378	CDD:237987	57/113 (50%)
		armadillo repeat	267..292	CDD:293788	15/24 (63%)
		armadillo repeat	300..336	CDD:293788	16/35 (46%)
		armadillo repeat	342..376	CDD:293788	13/33 (39%)
		ARM	356..461	CDD:237987	48/104 (46%)
		armadillo repeat	384..421	CDD:293788	17/36 (47%)
		armadillo repeat	427..461	CDD:293788	13/33 (39%)
		Arm_3	473..517	CDD:292804	25/44 (57%)
KPNA2	NP_001307540.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..27		7/15 (47%)
		SRP1	10..528	CDD:227396	248/549 (45%)
		IBB	10..98	CDD:280005	36/117 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	43..72		12/59 (20%)
		Nuclear localization signal. /evidence=ECO:0000250	45..54		5/8 (63%)
		ARM 1, truncated	71..111		13/66 (20%)
		ARM 2	112..151		19/38 (50%)
		ARM	113..238	CDD:237987	64/124 (52%)
		armadillo repeat	115..147	CDD:293788	14/31 (45%)
		NLS binding site (major). /evidence=ECO:0000250	142..238		53/95 (56%)
		armadillo repeat	155..191	CDD:293788	23/35 (66%)
		armadillo repeat	197..236	CDD:293788	14/38 (37%)
		ARM 4	200..244		18/43 (42%)
		ARM 5	246..282		18/35 (51%)
		ARM	252..364	CDD:237987	57/111 (51%)
		armadillo repeat	253..278	CDD:293788	15/24 (63%)
		ARM 6	283..322		17/38 (45%)
		armadillo repeat	286..322	CDD:293788	16/35 (46%)
		NLS binding site (minor). /evidence=ECO:0000250	315..403		42/87 (48%)
		armadillo repeat	328..362	CDD:293788	13/33 (39%)
		ARM	329..449	CDD:237987	54/119 (45%)
		ARM 8	367..409		19/41 (46%)
		armadillo repeat	370..404	CDD:293788	15/33 (45%)
		ARM 9	410..456		20/46 (43%)
		armadillo repeat	413..447	CDD:293788	13/33 (39%)
		ARM 10, atypical	457..496		21/38 (55%)
		Arm_3	458..508	CDD:292804	28/49 (57%)
		armadillo repeat	460..495	CDD:293788	21/34 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100442
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730