Protein Alignment Kap-alpha1 and KPNA1

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_002255.3
• Gene: KPNA1 / 3836
• HGNCID: 6394
• Length: 538
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 336/543 - (61%)
• Similarity: 401/543 - (73%)
• Gaps: 30/543 - (5%)

  Fly     9 YKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTD---NEQQAAD 70
            |||.:|:..||||||||.|:||||.|||:||||||||    ||:......|..:|   :|.|.::
Human    14 YKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNV----ATAEEETEEEVMSDGGFHEAQISN 74

  Fly    71 MHMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEEVIQ 135
            |.||   .||             ||..:||:|:||....:||.||||||||||::|||||:|||.
Human    75 MEMA---PGG-------------VITSDMIEMIFSKSPEQQLSATQKFRKLLSKEPNPPIDEVIS 123

  Fly   136 -KGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQEQ 199
             .|:|.:||.||:...|.|||||:||.|||||||.|.||::||:||||||||:||||..:|||||
Human   124 TPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFIELLSSEFEDVQEQ 188

  Fly   200 AVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKIS 264
            ||||||||||||.||||::|...||.|||.:.|..:|:||.|||||.|||||||||||.:|||:|
Human   189 AVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLCRGKSPPPEFAKVS 253

  Fly   265 HGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAALR 329
            ..|.:|:.||..:|.|||:|.|||:.||||||||||||||||||||||||||:|....|.:.|||
Human   254 PCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELLMHNDYKVVSPALR 318

  Fly   330 AVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIFP 394
            ||||||||||.||||||..:||..:.|||.|..|:||||:|||||||.||||.|||.:|:|||||
Human   319 AVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNRAQIQTVIDANIFP 383

  Fly   395 QLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNALE 459
            .|:.|:|||||:||||||||||||||.|:.|||.|||::||:.|:||.|||:||.|||||||.||
Human   384 ALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVMDSKIVQVALNGLE 448

  Fly   460 NILKAGEKFQTRP----NPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNEEEDSRV 520
            |||:.||:...|.    |||...|||..||||||:||:|||::||.|:|.:||.|||.|:|||.:
Human   449 NILRLGEQEAKRNGTGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGTEDEDSSI 513

  Fly   521 APVA--GTQQFEFDPDNMPSTGF 541
            ||..  ..||:.|.....|..||
Human   514 APQVDLNQQQYIFQQCEAPMEGF 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	336/543 (62%)
		armadillo repeat	133..165	CDD:293788	18/32 (56%)
		armadillo repeat	173..209	CDD:293788	28/35 (80%)
		armadillo repeat	215..250	CDD:293788	19/34 (56%)
		armadillo repeat	267..292	CDD:293788	12/24 (50%)
		armadillo repeat	300..336	CDD:293788	27/35 (77%)
		armadillo repeat	342..376	CDD:293788	21/33 (64%)
		armadillo repeat	384..421	CDD:293788	28/36 (78%)
		armadillo repeat	427..461	CDD:293788	23/33 (70%)
KPNA1	NP_002255.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..36		14/21 (67%)
		SRP1	33..516	CDD:227396	316/502 (63%)
		nuclear localization signal	42..51		8/12 (67%)
		ARM 1, truncated	77..117		25/55 (45%)
		ARM 2	118..161		26/42 (62%)
		armadillo repeat	128..154	CDD:293788	15/25 (60%)
		NLS binding site (major). /evidence=ECO:0000250|UniProtKB:P52293	149..241		65/91 (71%)
		armadillo repeat	162..198	CDD:293788	28/35 (80%)
		armadillo repeat	204..239	CDD:293788	19/34 (56%)
		ARM 4	207..245		23/37 (62%)
		Binding to RAG1. /evidence=ECO:0000269|PubMed:8052633	245..437		132/191 (69%)
		armadillo repeat	256..281	CDD:293788	12/24 (50%)
		armadillo repeat	289..325	CDD:293788	27/35 (77%)
		NLS binding site (minor). /evidence=ECO:0000250|UniProtKB:P52293	318..406		64/87 (74%)
		armadillo repeat	373..409	CDD:293788	27/35 (77%)
		ARM 9	413..457		30/43 (70%)
		armadillo repeat	416..450	CDD:293788	23/33 (70%)
		ARM 10, atypical	460..504		24/43 (56%)