Protein Alignment Kap-alpha1 and Kpna7

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001334460.1
• Gene: Kpna7 / 381686
• MGIID: 2141165
• Length: 520
• Species: Mus musculus
• Alignment Length: 566
• Identity: 188/566 - (33%)
• Similarity: 295/566 - (52%)
• Gaps: 79/566 - (13%)

  Fly     2 SASHKQRYKNAALDSTEM---RRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTD 63
            |.:.|:|.||......||   |::|....:||||.::::|:.||||:
Mouse     4 SKAPKERLKNYKYRGKEMSLPRQQRIASSLQLRKTRKDEQVLKRRNI------------------ 50

  Fly    64 NEQQAADMHMADSSTGGQNEEAAGSGAQPSVIN---EEMIQMLFSGRENEQLEATQKFRKLLSRD 125
                  |:..:|..          |.|....:|   :::||.:.|........||:..|:::|::
Mouse    51 ------DLFSSDMV----------SQALVKEVNFTLDDIIQAVNSSDPILHFRATRAAREMISQE 99

  Fly   126 PNPPIEEVIQKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLS 190
            ..||:..:|:.|::|:.|.||:.:.:..|||||||.|||||||||:||:.|::.||:...|:||.
Mouse   100 NTPPLNLIIEAGLIPKLVDFLKATPHPKLQFEAAWVLTNIASGTSEQTRAVVKEGAIQPLIELLC 164

  Fly   191 SPHDDVQEQAVWALGNI---------------------AGDSPMCRDHLLGSGILEPLLHVLSNS 234
            |||..|.||||||||||                     |||....||.::.:..:..|::::|..
Mouse   165 SPHLTVSEQAVWALGNIADRKMPDTQVQIFTPSTREAKAGDCAEFRDCVISNNAIPHLINLISKG 229

  Fly   235 DRITMIRNAVWTLSNLCRGKSPPADFAKISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDK 299
            ..||.:||..||||||||.|.|....:.:...||.|.:||.:.|.::|:|||||:.||:.|..:.
Mouse   230 IPITFLRNISWTLSNLCRNKDPYPSESAVRQMLPPLCQLLLHRDNEILADTCWALSYLTKGGKEY 294

  Fly   300 IQAVIDAGVCRRLVELLLHPQQNVSTAALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAET 364
            |..|:..|:..|||||:...:.::|...|..:||||.|.|:|||:.:....|..:..:|.....:
Mouse   295 IHHVVTTGILPRLVELMTSSELSISIPCLHTIGNIVAGTDEQTQMAIDAGMLKVLGQVLKHPKTS 359

  Fly   365 IKKESCWTISNIAAGNREQIQALINANIFPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHY 429
            |:..:.||:||:|||.|.|::.|: .|:.|.|:.:::.||.|.:||....:.|..:..:.:|:..
Mouse   360 IQVLAAWTMSNVAAGPRHQVEQLL-CNLLPILVDLLRNAELKVQKEVVCTVINIATGASQDQLTL 423

  Fly   430 LVQVGCVPPMCDFLTVVDSDIVQVALNALENILKAGEKFQTRPNPYAITIEECGGLDKIEYLQAH 494
            |...|.:.||...|:..|.::|.:.|:.:..:|:..:..|.:...| ..||:.||.:|||.||.|
Mouse   424 LAHSGILEPMLSLLSAPDLEVVIIVLDIISYLLQHIDNLQEKKRLY-FQIEKFGGFEKIECLQHH 487

  Fly   495 ENRDIYHKSFYIIEQYFGNEEEDSRVAPVAGTQQFEFDPDNMPSTG 540
            .|..|.:.:..|||:||.   ||.             |.|::|..|
Mouse   488 HNISISNSALDIIEKYFC---EDG-------------DGDSLPGPG 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	188/566 (33%)
		armadillo repeat	133..165	CDD:293788	15/31 (48%)
		armadillo repeat	173..209	CDD:293788	21/56 (38%)
		armadillo repeat	215..250	CDD:293788	12/34 (35%)
		armadillo repeat	267..292	CDD:293788	12/24 (50%)
		armadillo repeat	300..336	CDD:293788	13/35 (37%)
		armadillo repeat	342..376	CDD:293788	8/33 (24%)
		armadillo repeat	384..421	CDD:293788	10/36 (28%)
		armadillo repeat	427..461	CDD:293788	8/33 (24%)
Kpna7	NP_001334460.1	SRP1	2..513	CDD:227396	186/560 (33%)
		armadillo repeat	107..139	CDD:293788	15/31 (48%)
		armadillo repeat	147..183	CDD:293788	21/35 (60%)
		armadillo repeat	210..245	CDD:293788	12/34 (35%)
		armadillo repeat	262..287	CDD:293788	12/24 (50%)
		armadillo repeat	295..331	CDD:293788	13/35 (37%)
		armadillo repeat	337..371	CDD:293788	8/33 (24%)
		armadillo repeat	379..412	CDD:293788	9/33 (27%)
		armadillo repeat	420..455	CDD:293788	9/34 (26%)