Protein Alignment Kap-alpha1 and kpna3

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_958477.2
• Gene: kpna3 / 368640
• ZFINID: ZDB-GENE-030616-541
• Length: 520
• Species: Danio rerio
• Alignment Length: 547
• Identity: 260/547 - (47%)
• Similarity: 342/547 - (62%)
• Gaps: 42/547 - (7%)

  Fly     4 SHK-QRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQQ 67
            :|: :.:||...|...|||.|.||.::||||||::.|.|:|||..|          ||..|::
Zfish     9 NHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQE----------ESLEDSD-- 61

  Fly    68 AADMHMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEE 132
                  .||...|||           |..:.::|...|.....||.|.|..|||||.|.||||::
Zfish    62 ------VDSDFKGQN-----------VTLDAILQNATSDNAVVQLSAVQAARKLLSSDRNPPIDD 109

  Fly   133 VIQKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQ 197
            :|:.||:|..|..|....|.:|||||||.|||||||||.||:.|:::.|||:|:.||.|||.:|.
Zfish   110 LIKCGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVKSNAVPLFLRLLHSPHQNVC 174

  Fly   198 EQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAK 262
            ||||||||||.||.|.|||:::..|:::|||..::.|..||.:||..|.:.||||.|.||.....
Zfish   175 EQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMET 239

  Fly   263 ISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAA 327
            :...||.|..|:.:||.::|.||.||:.||:||.|::||.|||:||...||.||.|.:..|.|||
Zfish   240 VQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPYLVPLLSHQEVKVQTAA 304

  Fly   328 LRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANI 392
            ||||||||||.|:||||:|..:.||..|.||....|.|.||:.|.:|||.|||::|:||:|:|.:
Zfish   305 LRAVGNIVTGTDEQTQVVLNCDVLTHFSTLLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGL 369

  Fly   393 FPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNA 457
            .|.::..:...:|.|:|||||||:|.|.||..:|:.||||...:||.|:.|:|.||.:|||.|:.
Zfish   370 IPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDG 434

  Fly   458 LENIL-KAGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNE--EEDSR 519
            |:||| .|||:..|    .|..|||||||:|||.||.|||.|||..:|.||:|||..:  :||..
Zfish   435 LKNILIMAGEEAST----IAEIIEECGGLEKIENLQQHENEDIYKLAFEIIDQYFSGDDIDEDPS 495

  Fly   520 VAPVA---GTQQFEFDPDNMPSTGFNF 543
            :.|.|   ||  |.||..|:.:..|.|
Zfish   496 LIPEATQGGT--FNFDSSNLQAKEFKF 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	259/545 (48%)
		armadillo repeat	133..165	CDD:293788	16/31 (52%)
		armadillo repeat	173..209	CDD:293788	22/35 (63%)
		armadillo repeat	215..250	CDD:293788	12/34 (35%)
		armadillo repeat	267..292	CDD:293788	11/24 (46%)
		armadillo repeat	300..336	CDD:293788	23/35 (66%)
		armadillo repeat	342..376	CDD:293788	15/33 (45%)
		armadillo repeat	384..421	CDD:293788	16/36 (44%)
		armadillo repeat	427..461	CDD:293788	16/33 (48%)
kpna3	NP_958477.2	SRP1	2..519	CDD:227396	258/544 (47%)
		HEAT repeat	73..104	CDD:293787	12/30 (40%)
		armadillo repeat	109..142	CDD:293788	16/32 (50%)
		armadillo repeat	150..186	CDD:293788	22/35 (63%)
		armadillo repeat	192..227	CDD:293788	12/34 (35%)
		armadillo repeat	244..269	CDD:293788	11/24 (46%)
		armadillo repeat	277..313	CDD:293788	23/35 (66%)
		armadillo repeat	319..353	CDD:293788	15/33 (45%)
		armadillo repeat	361..395	CDD:293788	14/33 (42%)
		armadillo repeat	404..438	CDD:293788	16/33 (48%)