Protein Alignment Kap-alpha1 and Kpna4

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001014793.1
• Gene: Kpna4 / 361959
• RGDID: 1311483
• Length: 521
• Species: Rattus norvegicus
• Alignment Length: 543
• Identity: 249/543 - (45%)
• Similarity: 340/543 - (62%)
• Gaps: 40/543 - (7%)

  Fly     7 QRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQQAADM 71
            :.:||...|...|||:|.||.::||||||::.|.|||||..|....      :|:.|.:.:..:.
  Rat    13 KNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPQEDICE------DSDIDGDYRVQNT 71

  Fly    72 HMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEEVIQK 136
            .:                       |.::|...|..:..||.|.|..|||||.|.||||:::|:.
  Rat    72 SL-----------------------EAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKS 113

  Fly   137 GIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQEQAV 201
            ||:|..|..|....|.:|||||||.|||||||||:||:.|:::.|||:|:.||.|||.:|.||||
  Rat   114 GILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAV 178

  Fly   202 WALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKISHG 266
            ||||||.||.|.|||:::..|:::|||..:|.|..||.:||..|.:.||||.|.||.....|...
  Rat   179 WALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEI 243

  Fly   267 LPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAALRAV 331
            ||.|..|:.:||.::|.||.||:.||:|..|::||.|||:|:...||.||.|.:..|.|||||||
  Rat   244 LPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAV 308

  Fly   332 GNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIFPQL 396
            ||||||.|:||||:|..:||:....||....|.|.||:.|.:|||.|||::|:||:|:||:.|.:
  Rat   309 GNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMI 373

  Fly   397 MVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNALENI 461
            :.::...:|.|:|||||||:|.|.||..:|:.||:|...:||.|:.|||.|:.:|||.|:.|.||
  Rat   374 IHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNI 438

  Fly   462 LKAGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNE--EEDSRVAPVA 524
            ||..|   .:....|..|||||||:|||.||.|||.|||..::.||:|:|.::  :||..:.|.:
  Rat   439 LKMAE---DQAETIANLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPES 500

  Fly   525 ---GTQQFEFDPD-NMPSTGFNF 543
               ||  |.|:.. |:|:.||.|
  Rat   501 VQGGT--FGFNSSTNVPTEGFQF 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	248/541 (46%)
		armadillo repeat	133..165	CDD:293788	16/31 (52%)
		armadillo repeat	173..209	CDD:293788	22/35 (63%)
		armadillo repeat	215..250	CDD:293788	13/34 (38%)
		armadillo repeat	267..292	CDD:293788	11/24 (46%)
		armadillo repeat	300..336	CDD:293788	22/35 (63%)
		armadillo repeat	342..376	CDD:293788	14/33 (42%)
		armadillo repeat	384..421	CDD:293788	17/36 (47%)
		armadillo repeat	427..461	CDD:293788	15/33 (45%)
Kpna4	NP_001014793.1	SRP1	11..513	CDD:227396	244/533 (46%)
		armadillo repeat	73..98	CDD:293788	8/47 (17%)
		armadillo repeat	109..142	CDD:293788	16/32 (50%)
		armadillo repeat	150..186	CDD:293788	22/35 (63%)
		armadillo repeat	192..227	CDD:293788	13/34 (38%)
		armadillo repeat	244..269	CDD:293788	11/24 (46%)
		armadillo repeat	279..311	CDD:293788	18/31 (58%)
		armadillo repeat	319..355	CDD:293788	16/35 (46%)
		armadillo repeat	361..395	CDD:293788	15/33 (45%)
		armadillo repeat	404..438	CDD:293788	15/33 (45%)