Protein Alignment Kap-alpha1 and Kpna5

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: NP_001020284.2
• Gene: Kpna5 / 294392
• RGDID: 1561324
• Length: 539
• Species: Rattus norvegicus
• Alignment Length: 540
• Identity: 328/540 - (60%)
• Similarity: 392/540 - (72%)
• Gaps: 26/540 - (4%)

  Fly     9 YKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQQAADMHM 73
            |||.||:..||||||||.||||||.|||:||||||||.|           ..|.|...::.....
  Rat    17 YKNKALNPQEMRRRREEEGIQLRKQKREEQLFKRRNVSL-----------PRNDDCMLESPIQDP 70

  Fly    74 ADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEEVIQK-G 137
            ..|||....||        .:|..:||||:||....:||.||||||||||::|||||::|||| |
  Rat    71 DVSSTVPIPEE--------DMITADMIQMIFSNNAEQQLTATQKFRKLLSKEPNPPIDQVIQKPG 127

  Fly   138 IVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQEQAVW 202
            :|.:||.||..:.|.||||||||.||||||||...||||||.|||||||.||:|.|:||||||||
  Rat   128 VVQRFVKFLERNENCTLQFEAAWALTNIASGTFLHTKVVIETGAVPIFIRLLTSEHEDVQEQAVW 192

  Fly   203 ALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKISHGL 267
            ||||||||:..|||.:|...||.|||.:|:||:|:|..|||||.||||||||:||.:|:|:|..|
  Rat   193 ALGNIAGDNAECRDFVLNCEILPPLLELLTNSNRLTTTRNAVWALSNLCRGKNPPPNFSKVSPCL 257

  Fly   268 PILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAALRAVG 332
            .:|:|||..:|.|||:|.|||:.|||||||||||.|||:||||||||||:|....|.:.||||||
  Rat   258 NVLSRLLFSSDPDVLADVCWALSYLSDGPNDKIQVVIDSGVCRRLVELLMHNDYKVVSPALRAVG 322

  Fly   333 NIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIFPQLM 397
            |||||||.||||||..:||.|:.|||.|..|:::||:|||||||.||||.||||:|:.:|||.|:
  Rat   323 NIVTGDDIQTQVILNCSALPCLLHLLGSPKESVRKEACWTISNITAGNRMQIQAVIDGSIFPVLI 387

  Fly   398 VIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNALENIL 462
            .::|.|||:||||||||||||||.|..|||.|||.:||:.|:||.|||:||.|||||||.|||||
  Rat   388 EVLQKAEFRTRKEAAWAITNATSGGAPEQIRYLVTLGCIKPLCDLLTVMDSKIVQVALNGLENIL 452

  Fly   463 KAGEKFQTRP----NPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNEEEDSRVAPV 523
            :.||:...:.    |||...|||..||||||:||:|||::||.|:|.:||:|||.||:|..:.|.
  Rat   453 RLGERESKQNGVGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLIERYFGVEEDDPSLVPQ 517

  Fly   524 AGTQ--QFEFDPDNMPSTGF 541
            ...|  ||.|.....|..||
  Rat   518 VDEQQRQFLFQQCEAPGEGF 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	328/540 (61%)
		armadillo repeat	133..165	CDD:293788	21/32 (66%)
		armadillo repeat	173..209	CDD:293788	30/35 (86%)
		armadillo repeat	215..250	CDD:293788	20/34 (59%)
		armadillo repeat	267..292	CDD:293788	13/24 (54%)
		armadillo repeat	300..336	CDD:293788	25/35 (71%)
		armadillo repeat	342..376	CDD:293788	20/33 (61%)
		armadillo repeat	384..421	CDD:293788	25/36 (69%)
		armadillo repeat	427..461	CDD:293788	23/33 (70%)
Kpna5	NP_001020284.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		15/20 (75%)
		SRP1	36..528	CDD:227396	310/510 (61%)
		Nuclear localization signal. /evidence=ECO:0000250	45..54		7/8 (88%)
		ARM 1, truncated	76..118		23/49 (47%)
		ARM 2	119..162		28/42 (67%)
		armadillo repeat	122..155	CDD:293788	21/32 (66%)
		NLS binding site (major). /evidence=ECO:0000250	150..242		65/91 (71%)
		armadillo repeat	163..199	CDD:293788	30/35 (86%)
		armadillo repeat	205..240	CDD:293788	20/34 (59%)
		ARM 4	208..246		24/37 (65%)
		ARM 5	247..291		26/43 (60%)
		armadillo repeat	257..282	CDD:293788	13/24 (54%)
		armadillo repeat	290..326	CDD:293788	25/35 (71%)
		ARM 6	292..331		28/38 (74%)
		NLS binding site (minor). /evidence=ECO:0000250	319..407		60/87 (69%)
		armadillo repeat	332..366	CDD:293788	20/33 (61%)
		ARM 8	374..413		26/38 (68%)
		armadillo repeat	374..410	CDD:293788	24/35 (69%)
		ARM 9	414..456		28/41 (68%)
		armadillo repeat	417..451	CDD:293788	23/33 (70%)
		ARM 10, atypical	460..505		23/44 (52%)