DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kap-alpha1 and Kpna1

DIOPT Version :9

Sequence 1:	NP_524167.1	Gene:	Kap-alpha1 / 40160	FlyBaseID:	FBgn0024889	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_942021.2	Gene:	Kpna1 / 288064	RGDID:	735064	Length:	538	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	336/556 - (60%)
Similarity:	403/556 - (72%)	Gaps:	35/556 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSASHKQR-----YKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVES 60
            ||...|:.     |||.:|:..||||||||.|:||||.|||:||||||||    ||:......|.
  Rat     1 MSTPGKENFRLKSYKNKSLNPDEMRRRREEEGLQLRKQKREEQLFKRRNV----ATAEEETEEEV 61

  Fly    61 NTD---NEQQAADMHMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLL 122
            .:|   :|.|..:|.||   .||             ||..:|.:|:||....:||.|||||||||
  Rat    62 MSDGGFHEAQINNMEMA---PGG-------------VITSDMTEMIFSNSPEQQLSATQKFRKLL 110

  Fly   123 SRDPNPPIEEVIQ-KGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFI 186
            |::|||||:|||. .|:|.:||.||:...|.|||||:||.|||||||.|.||::||:||||||||
  Rat   111 SKEPNPPIDEVINTPGVVARFVEFLKRKENCTLQFESAWVLTNIASGNSLQTRIVIQAGAVPIFI 175

  Fly   187 DLLSSPHDDVQEQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLC 251
            :||||..:|||||||||||||||||.||||::|...||.|||.:.|..:|:||.|||||.|||||
  Rat   176 ELLSSEFEDVQEQAVWALGNIAGDSTMCRDYVLDCNILPPLLQLFSKQNRLTMTRNAVWALSNLC 240

  Fly   252 RGKSPPADFAKISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELL 316
            ||||||.:|||:|..|.:|:.||..:|.|||:|.|||:.||||||||||||||||||||||||||
  Rat   241 RGKSPPPEFAKVSPCLNVLSWLLFVSDTDVLADACWALSYLSDGPNDKIQAVIDAGVCRRLVELL 305

  Fly   317 LHPQQNVSTAALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNR 381
            :|....|.:.|||||||||||||.||||||..:||..:.|||.|..|:||||:|||||||.||||
  Rat   306 MHNDYKVVSPALRAVGNIVTGDDIQTQVILNCSALQSLLHLLSSPKESIKKEACWTISNITAGNR 370

  Fly   382 EQIQALINANIFPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVV 446
            .|||.:|:||:||.|:.|:|||||:||||||||||||||.|:.|||.|||::||:.|:||.|||:
  Rat   371 AQIQTVIDANMFPALISILQTAEFRTRKEAAWAITNATSGGSAEQIKYLVELGCIKPLCDLLTVM 435

  Fly   447 DSDIVQVALNALENILKAGEKFQTRP----NPYAITIEECGGLDKIEYLQAHENRDIYHKSFYII 507
            |:.|||||||.|||||:.||:...|.    |||...|||..||||||:||:|||::||.|:|.:|
  Rat   436 DAKIVQVALNGLENILRLGEQEAKRNGSGINPYCALIEEAYGLDKIEFLQSHENQEIYQKAFDLI 500

  Fly   508 EQYFGNEEEDSRVAPVA--GTQQFEFDPDNMPSTGF 541
            |.|||.|:|||.:||..  ..||:.|.....|..||
  Rat   501 EHYFGTEDEDSSIAPQVDLSQQQYIFQQCEAPMEGF 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	336/556 (60%)
		IBB	3..116	CDD:280005	49/120 (41%)
		ARM	131..252	CDD:237987	81/121 (67%)
		armadillo repeat	133..165	CDD:293788	18/32 (56%)
		armadillo repeat	173..209	CDD:293788	28/35 (80%)
		armadillo repeat	215..250	CDD:293788	19/34 (56%)
		ARM	264..378	CDD:237987	78/113 (69%)
		armadillo repeat	267..292	CDD:293788	12/24 (50%)
		armadillo repeat	300..336	CDD:293788	27/35 (77%)
		armadillo repeat	342..376	CDD:293788	21/33 (64%)
		ARM	356..461	CDD:237987	74/104 (71%)
		armadillo repeat	384..421	CDD:293788	27/36 (75%)
		armadillo repeat	427..461	CDD:293788	22/33 (67%)
		Arm_3	473..517	CDD:292804	27/43 (63%)
Kpna1	NP_942021.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		21/39 (54%)
		SRP1	33..516	CDD:227396	313/502 (62%)
		Nuclear localization signal. /evidence=ECO:0000250	42..51		8/12 (67%)
		ARM 1, truncated	77..117		24/55 (44%)
		ARM 2. /evidence=ECO:0000305	118..161		26/42 (62%)
		armadillo repeat	128..154	CDD:293788	15/25 (60%)
		NLS binding site (major). /evidence=ECO:0000250	149..241		65/91 (71%)
		armadillo repeat	162..198	CDD:293788	28/35 (80%)
		armadillo repeat	204..239	CDD:293788	19/34 (56%)
		ARM 4. /evidence=ECO:0000305	207..245		23/37 (62%)
		Binding to RAG1	245..437		131/191 (69%)
		armadillo repeat	256..281	CDD:293788	12/24 (50%)
		armadillo repeat	289..325	CDD:293788	27/35 (77%)
		NLS binding site (minor). /evidence=ECO:0000250	318..406		63/87 (72%)
		armadillo repeat	373..409	CDD:293788	26/35 (74%)
		ARM 9. /evidence=ECO:0000305	413..457		29/43 (67%)
		armadillo repeat	416..450	CDD:293788	22/33 (67%)
		ARM 10, atypical	460..504		24/43 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166337670
Domainoid	1	1.000	75	1.000	Domainoid score	I8823
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	637	1.000	Inparanoid score	I797
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	1	1.000	-	-		otm44655
orthoMCL	1	0.900	-	-		OOG6_100442
Panther	1	1.100	-	-	LDO	PTHR23316
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X492
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.910