Protein Alignment Kap-alpha1 and KPNA6

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: XP_005270768.1
• Gene: KPNA6 / 23633
• HGNCID: 6399
• Length: 566
• Species: Homo sapiens
• Alignment Length: 544
• Identity: 340/544 - (62%)
• Similarity: 405/544 - (74%)
• Gaps: 37/544 - (6%)

  Fly     9 YKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQQAA-DMH 72
            |||.||:..||||||||.||||||.||||||||||||.|               .||:.|. |..
Human    47 YKNNALNPEEMRRRREEEGIQLRKQKREQQLFKRRNVEL---------------INEEAAMFDSL 96

  Fly    73 MAD---SSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEEVI 134
            :.|   |||.|:           |||..||::||||...:.||..|||||||||::|:|||:|||
Human    97 LMDSYVSSTTGE-----------SVITREMVEMLFSDDSDLQLATTQKFRKLLSKEPSPPIDEVI 150

  Fly   135 Q-KGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQE 198
            . ..:|.:||.||:.:.|.||||||||.|||||||||||||:|||||||||||:||:|..:||||
Human   151 NTPRVVDRFVEFLKRNENCTLQFEAAWALTNIASGTSQQTKIVIEAGAVPIFIELLNSDFEDVQE 215

  Fly   199 QAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAKI 263
            |||||||||||||.:|||::|...||.|||.:|:.|.|:||.|||||.||||||||:||.:|||:
Human   216 QAVWALGNIAGDSSVCRDYVLNCSILNPLLTLLTKSTRLTMTRNAVWALSNLCRGKNPPPEFAKV 280

  Fly   264 SHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAAL 328
            |..||:|:|||..:|:|:|:|.|||:.|||||||:|||||||:||||||||||:|....|::.||
Human   281 SPCLPVLSRLLFSSDSDLLADACWALSYLSDGPNEKIQAVIDSGVCRRLVELLMHNDYKVASPAL 345

  Fly   329 RAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIF 393
            |||||||||||.||||||..:||.|:.|||.|..|:|:||:|||||||.||||.||||:|:||||
Human   346 RAVGNIVTGDDIQTQVILNCSALPCLLHLLSSPKESIRKEACWTISNITAGNRAQIQAVIDANIF 410

  Fly   394 PQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNAL 458
            |.|:.|:|.|||:||||||||||||||.||.|||.|||.:||:.|:||.|||:||.|||||||.|
Human   411 PVLIEILQKAEFRTRKEAAWAITNATSGGTPEQIRYLVSLGCIKPLCDLLTVMDSKIVQVALNGL 475

  Fly   459 ENILKAGEKFQTRP----NPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNEEEDSR 519
            ||||:.||:...|.    |||...|||..||||||:||:|||::||.|:|.:||.|||.|::||.
Human   476 ENILRLGEQEGKRSGSGVNPYCGLIEEAYGLDKIEFLQSHENQEIYQKAFDLIEHYFGVEDDDSS 540

  Fly   520 VAPVAG--TQQFEFDPDNMPSTGF 541
            :||...  .|||.|.....|..||
Human   541 LAPQVDETQQQFIFQQPEAPMEGF 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	340/544 (63%)
		armadillo repeat	133..165	CDD:293788	18/32 (56%)
		armadillo repeat	173..209	CDD:293788	29/35 (83%)
		armadillo repeat	215..250	CDD:293788	20/34 (59%)
		armadillo repeat	267..292	CDD:293788	13/24 (54%)
		armadillo repeat	300..336	CDD:293788	26/35 (74%)
		armadillo repeat	342..376	CDD:293788	21/33 (64%)
		armadillo repeat	384..421	CDD:293788	28/36 (78%)
		armadillo repeat	427..461	CDD:293788	23/33 (70%)
KPNA6	XP_005270768.1	SRP1	66..555	CDD:227396	322/514 (63%)
		armadillo repeat	156..182	CDD:293788	16/25 (64%)
		armadillo repeat	190..226	CDD:293788	29/35 (83%)
		armadillo repeat	232..267	CDD:293788	20/34 (59%)
		armadillo repeat	284..309	CDD:293788	13/24 (54%)
		armadillo repeat	317..353	CDD:293788	26/35 (74%)
		armadillo repeat	359..393	CDD:293788	21/33 (64%)
		armadillo repeat	401..437	CDD:293788	27/35 (77%)
		armadillo repeat	444..478	CDD:293788	23/33 (70%)