DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kap-alpha1 and ima-3

DIOPT Version :9

Sequence 1:	NP_524167.1	Gene:	Kap-alpha1 / 40160	FlyBaseID:	FBgn0024889	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_501227.1	Gene:	ima-3 / 177533	WormBaseID:	WBGene00002074	Length:	514	Species:	Caenorhabditis elegans

Alignment Length:	555	Identity:	239/555 - (43%)
Similarity:	328/555 - (59%)	Gaps:	55/555 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSASHKQRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNE 65
            ||::.:..|||.|.:.....:|.||| :.:||:|||:.:.||||:               ||..|
Worm     1 MSSNRQAYYKNNAKEQIGKEKRNEEV-VSIRKDKREEAISKRRNI---------------NTQIE 49

  Fly    66 QQAADMHMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGREN----EQLEATQKFRKLLSRDP 126
            .        ||.|         |...|...:..::::..:..::    |||.|.|:.||:||.|.
Worm    50 D--------DSET---------STTPPGPFDANLLRLTVAAAQSSDPAEQLTAVQQARKMLSTDR 97

  Fly   127 NPPIEEVIQKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSS 191
            ||||:::|..||:|..|..| :|.:..|||||||.|||||||||:||:.|:.|||||:|:.|||.
Worm    98 NPPIDDLIGSGILPVLVQCL-SSTDPNLQFEAAWALTNIASGTSEQTQAVVNAGAVPLFLQLLSC 161

  Fly   192 PHDDVQEQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSP 256
            .:.:|.||:|||||||.||.|..||:.|..|||:|||..::....|..:||..|.:.||||.|.|
Worm   162 GNLNVCEQSVWALGNIIGDGPHFRDYCLELGILQPLLQFINPEIPIGFLRNVTWVIVNLCRCKDP 226

  Fly   257 PADFAKISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQ 321
            ....|.:...||.|:.|:.:.|.::|.||.||:.||:||.|:.||.||:|.|...||.||.|...
Worm   227 APSPAVVRTILPALSLLIHHQDTNILIDTVWALSYLTDGGNEHIQMVIEAQVVTHLVPLLGHVDV 291

  Fly   322 NVSTAALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQA 386
            .|.|||||||||||||.|:|||::|....|..:..||....|.|.||:.|.:|||.|||::|:|.
Worm   292 KVQTAALRAVGNIVTGTDEQTQLVLDSGVLRFMPGLLAHYKEKINKEAVWFVSNITAGNQQQVQD 356

  Fly   387 LINANIFPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIV 451
            :.:|.|.|.::.::...:|.|:|||||||:|.|.||...|:..:|::|.:.|.|..|:..||.|:
Worm   357 VFDAGIMPMIIHLLDRGDFPTQKEAAWAISNVTISGRPNQVEQMVKLGVLRPFCAMLSCTDSQII 421

  Fly   452 QVALNALENILK-AGEKFQTRPNPYAIT--IEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGN 513
            ||.|:.:.|||| |||..:      .:|  |||||||||||.||.|||.|||..:|.||:.:|.:
Worm   422 QVVLDGINNILKMAGEAAE------QVTSEIEECGGLDKIENLQNHENEDIYKLAFEIIDNFFSS 480

  Fly   514 EEEDSRVAPVAGTQQFEFDPD-----NMPSTGFNF 543
            ::|...   |.|.|...|..|     :.|:.|:||
Worm   481 DDETGN---VEGAQSSAFGGDVPPVPDAPNGGWNF 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	237/553 (43%)
		IBB	3..116	CDD:280005	29/116 (25%)
		ARM	131..252	CDD:237987	63/120 (53%)
		armadillo repeat	133..165	CDD:293788	16/31 (52%)
		armadillo repeat	173..209	CDD:293788	21/35 (60%)
		armadillo repeat	215..250	CDD:293788	13/34 (38%)
		ARM	264..378	CDD:237987	56/113 (50%)
		armadillo repeat	267..292	CDD:293788	10/24 (42%)
		armadillo repeat	300..336	CDD:293788	22/35 (63%)
		armadillo repeat	342..376	CDD:293788	12/33 (36%)
		ARM	356..461	CDD:237987	43/104 (41%)
		armadillo repeat	384..421	CDD:293788	15/36 (42%)
		armadillo repeat	427..461	CDD:293788	11/33 (33%)
		Arm_3	473..517	CDD:292804	24/45 (53%)
ima-3	NP_501227.1	IBB	4..87	CDD:280005	29/115 (25%)
		SRP1	19..513	CDD:227396	233/537 (43%)
		HEAT repeat	65..92	CDD:293787	6/26 (23%)
		ARM	102..222	CDD:237987	63/120 (53%)
		armadillo repeat	103..135	CDD:293788	16/32 (50%)
		armadillo repeat	143..179	CDD:293788	21/35 (60%)
		armadillo repeat	185..220	CDD:293788	13/34 (38%)
		ARM	236..348	CDD:237987	56/111 (50%)
		armadillo repeat	237..262	CDD:293788	10/24 (42%)
		armadillo repeat	272..304	CDD:293788	18/31 (58%)
		armadillo repeat	315..346	CDD:293788	10/30 (33%)
		armadillo repeat	354..391	CDD:293788	15/36 (42%)
		ARM	355..479	CDD:237987	59/129 (46%)
		armadillo repeat	397..431	CDD:293788	11/33 (33%)
		armadillo repeat	443..476	CDD:293788	23/32 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2158
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860