DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kap-alpha1 and Kpna3

DIOPT Version :9

Sequence 1:	NP_524167.1	Gene:	Kap-alpha1 / 40160	FlyBaseID:	FBgn0024889	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_032492.1	Gene:	Kpna3 / 16648	MGIID:	1100863	Length:	521	Species:	Mus musculus

Alignment Length:	548	Identity:	257/548 - (46%)
Similarity:	343/548 - (62%)	Gaps:	43/548 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SHK-QRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQQ 67
            :|: :.:||...|...|||.|.||.::||||||::.|.|:|||..|          ||..|::
Mouse     9 NHRIKSFKNKGRDVETMRRHRNEVTVELRKNKRDEHLLKKRNVPQE----------ESLEDSD-- 61

  Fly    68 AADMHMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEE 132
                  .|:....||           |..|.::|...|.....||.|.|..|||||.|.||||::
Mouse    62 ------VDADFKAQN-----------VTLEAILQNATSDNPVVQLSAVQAARKLLSSDRNPPIDD 109

  Fly   133 VIQKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQ 197
            :|:.||:|..|..|....|.:|||||||.|||||||||.||:.|:::.|||:|:.||.|||.:|.
Mouse   110 LIKSGILPILVKCLERDDNPSLQFEAAWALTNIASGTSAQTQAVVQSNAVPLFLRLLHSPHQNVC 174

  Fly   198 EQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFAK 262
            ||||||||||.||.|.|||:::..|:::|||..::.|..||.:||..|.:.||||.|.||.....
Mouse   175 EQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFINPSIPITFLRNVTWVIVNLCRNKDPPPPMET 239

  Fly   263 ISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAA 327
            :...||.|..|:.:||.::|.||.||:.||:||.|::||.|||:||...||.||.|.:..|.|||
Mouse   240 VQEILPALCVLIYHTDINILVDTVWALSYLTDGGNEQIQMVIDSGVVPFLVPLLSHQEVKVQTAA 304

  Fly   328 LRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANI 392
            ||||||||||.|:||||:|..:.|:...:||....|.|.||:.|.:|||.|||::|:||:|:|.:
Mouse   305 LRAVGNIVTGTDEQTQVVLNCDVLSHFPNLLSHPKEKINKEAVWFLSNITAGNQQQVQAVIDAGL 369

  Fly   393 FPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALNA 457
            .|.::..:...:|.|:|||||||:|.|.||..:|:.||||...:||.|:.|:|.||.:|||.|:.
Mouse   370 IPMIIHQLAKGDFGTQKEAAWAISNLTISGRKDQVEYLVQQNVIPPFCNLLSVKDSQVVQVVLDG 434

  Fly   458 LENIL-KAGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNE--EEDSR 519
            |:||| .||::..|    .|..|||||||:|||.||.|||.|||..:|.||:|||..:  :||..
Mouse   435 LKNILIMAGDEAST----IAEIIEECGGLEKIEVLQQHENEDIYKLAFEIIDQYFSGDDIDEDPS 495

  Fly   520 VAPVA---GTQQFEFDPD-NMPSTGFNF 543
            :.|.|   ||  :.|||. |:.:..|||
Mouse   496 LIPEATQGGT--YNFDPTANLQTKEFNF 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	255/546 (47%)
		IBB	3..116	CDD:280005	35/112 (31%)
		ARM	131..252	CDD:237987	64/120 (53%)
		armadillo repeat	133..165	CDD:293788	16/31 (52%)
		armadillo repeat	173..209	CDD:293788	22/35 (63%)
		armadillo repeat	215..250	CDD:293788	12/34 (35%)
		ARM	264..378	CDD:237987	59/113 (52%)
		armadillo repeat	267..292	CDD:293788	11/24 (46%)
		armadillo repeat	300..336	CDD:293788	23/35 (66%)
		armadillo repeat	342..376	CDD:293788	13/33 (39%)
		ARM	356..461	CDD:237987	49/104 (47%)
		armadillo repeat	384..421	CDD:293788	16/36 (44%)
		armadillo repeat	427..461	CDD:293788	16/33 (48%)
		Arm_3	473..517	CDD:292804	25/45 (56%)
Kpna3	NP_032492.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		7/19 (37%)
		SRP1	7..521	CDD:227396	255/546 (47%)
		Nuclear localization signal. /evidence=ECO:0000250	43..52		4/8 (50%)
		ARM 1, truncated	66..106		17/50 (34%)
		armadillo repeat	73..98	CDD:293788	8/24 (33%)
		ARM 2	107..149		24/41 (59%)
		armadillo repeat	109..142	CDD:293788	16/32 (50%)
		NLS binding site (major). /evidence=ECO:0000250	137..229		51/91 (56%)
		armadillo repeat	150..186	CDD:293788	22/35 (63%)
		armadillo repeat	192..227	CDD:293788	12/34 (35%)
		ARM 4	195..233		15/37 (41%)
		ARM 5	234..278		17/43 (40%)
		armadillo repeat	244..269	CDD:293788	11/24 (46%)
		armadillo repeat	277..313	CDD:293788	23/35 (66%)
		ARM 6	279..318		25/38 (66%)
		NLS binding site (minor). /evidence=ECO:0000250	306..394		44/87 (51%)
		armadillo repeat	319..353	CDD:293788	13/33 (39%)
		ARM 8	361..400		17/38 (45%)
		armadillo repeat	361..395	CDD:293788	14/33 (42%)
		ARM 9	401..443		20/41 (49%)
		armadillo repeat	404..438	CDD:293788	16/33 (48%)
		ARM 10, atypical	447..485		24/41 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5064
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54553
OrthoDB	1	1.010	-	-		D1111872at2759
OrthoFinder	1	1.000	-	-		FOG0000157
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2158
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860