Protein Alignment Kap-alpha1 and Kap-alpha3

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: XP_321878.4
• Gene: Kap-alpha3 / 1281905
• VectorBaseID: AGAMI1_013593
• Length: 518
• Species: Anopheles gambiae
• Alignment Length: 547
• Identity: 244/547 - (44%)
• Similarity: 331/547 - (60%)
• Gaps: 41/547 - (7%)

  Fly     2 SASHKQRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQ 66
            |.:..|.:||...|..||||||.||.::|||||||:.:.|||||   |.|:       .:||.|.
Mosquito     8 SKNRMQGFKNKGKDQDEMRRRRTEVTVELRKNKREETILKRRNV---PQTT-------ESTDEED 62

  Fly    67 QAADMHMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIE 131
            .....::.      :..|.||:                |..:..||.|.|..|:|||.|.||||.
Mosquito    63 YTLQSNLK------KLVEKAGN----------------SSDKEGQLAAVQAARRLLSSDRNPPIN 105

  Fly   132 EVIQKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDV 196
            .:|..||:|..|..|....|..|||||||.||||||||:.||..|:.|||||:|:.||:||..:|
Mosquito   106 NLIDSGILPILVNCLEQDDNQVLQFEAAWALTNIASGTAAQTNQVVRAGAVPLFLRLLNSPAPNV 170

  Fly   197 QEQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFA 261
            .||||||||||.||.|..||:::..|:::|||..:.....|..:||..|.:.||||.|.||...|
Mosquito   171 CEQAVWALGNIIGDGPSLRDYVIKLGVVQPLLSFIQPEIPIPFLRNVTWVIVNLCRNKDPPPPAA 235

  Fly   262 KISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTA 326
            .|...||.|..|:.:||.::|.||.||:.||:||.|::||.|||:||..:|:.||.|.:..|.||
Mosquito   236 TILEILPALNMLIHHTDINILVDTVWALSYLTDGGNEQIQLVIDSGVVPKLIPLLSHVEVKVQTA 300

  Fly   327 ALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINAN 391
            |||||||||||.|.||||:|..:||:....||..:.:.|:||:.|.:|||.|||:.|:||:|:|.
Mosquito   301 ALRAVGNIVTGSDDQTQVVLNCDALSHFPKLLTHSKDKIRKEAVWFLSNITAGNQSQVQAVIDAG 365

  Fly   392 IFPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALN 456
            :.|:::..::..:|.|:|||||||:|.|.||..||:..|:..|.|||.||.|...|..::.|.|:
Mosquito   366 LLPKVIENLKHGDFHTQKEAAWAISNLTISGNREQVAQLINDGAVPPFCDLLMCQDCQVINVVLD 430

  Fly   457 ALENILK-AGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNEEEDS-- 518
            .:.|:|| ||...:...|    .||||.|:.|||.||.|||.:||..::.||||:|.::.:::
Mosquito   431 GINNMLKLAGPHAEHVAN----LIEECDGVSKIEVLQNHENVEIYKLAYDIIEQFFSDDVDEAVL 491

  Fly   519 -RVAPVAGTQQFEFDPD-NMPSTGFNF 543
             .:.|.|....|:|:.: |:|..||||
Mosquito   492 EDLRPAADENAFQFNQNPNIPRDGFNF 518

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	242/545 (44%)
		armadillo repeat	133..165	CDD:293788	16/31 (52%)
		armadillo repeat	173..209	CDD:293788	23/35 (66%)
		armadillo repeat	215..250	CDD:293788	10/34 (29%)
		armadillo repeat	267..292	CDD:293788	11/24 (46%)
		armadillo repeat	300..336	CDD:293788	22/35 (63%)
		armadillo repeat	342..376	CDD:293788	13/33 (39%)
		armadillo repeat	384..421	CDD:293788	16/36 (44%)
		armadillo repeat	427..461	CDD:293788	11/33 (33%)
Kap-alpha3	XP_321878.4	SRP1	8..510	CDD:227396	238/537 (44%)
		armadillo repeat	107..139	CDD:293788	16/31 (52%)
		armadillo repeat	147..183	CDD:293788	23/35 (66%)
		armadillo repeat	189..224	CDD:293788	10/34 (29%)
		armadillo repeat	241..266	CDD:293788	11/24 (46%)
		armadillo repeat	274..310	CDD:293788	22/35 (63%)
		armadillo repeat	316..350	CDD:293788	13/33 (39%)
		armadillo repeat	358..392	CDD:293788	14/33 (42%)
		armadillo repeat	401..435	CDD:293788	11/33 (33%)