Protein Alignment Kap-alpha1 and Pen

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: XP_318886.3
• Gene: Pen / 1279204
• VectorBaseID: AGAMI1_004846
• Length: 522
• Species: Anopheles gambiae
• Alignment Length: 540
• Identity: 229/540 - (42%)
• Similarity: 330/540 - (61%)
• Gaps: 36/540 - (6%)

  Fly     9 YKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQQAADMHM 73
            ||:.:..:||:|:||.||.::|||||:|.||.||||:                |::|
Mosquito    14 YKHGSKSNTELRQRRHEVTVELRKNKKEDQLLKRRNI----------------TEDE-------- 54

  Fly    74 ADSSTGGQNEEAAGSGAQPSVI--NEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIEEVIQK 136
                  |.......:.||..|.  .::::|.:.||:..::..|.|..||:|||:.||||:::|..
Mosquito    55 ------GPTSPLQENNAQSPVTLKFDDIMQYIRSGQPEKEFAAVQAARKMLSREKNPPIDKIIGL 113

  Fly   137 GIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDVQEQAV 201
            |:||..|.||..|....|||||||.|||||||||:|||.||::.|:|.||||||||...|.||||
Mosquito   114 GMVPVCVKFLSASDRPALQFEAAWALTNIASGTSEQTKAVIDSNAIPRFIDLLSSPSVTVAEQAV 178

  Fly   202 WALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSD-RITMIRNAVWTLSNLCRGKSPPADFAKISH 265
            |||||||||....||.:|....::.::.:::|.: :|:.:||.||.:|||||.|:|...|.:|..
Mosquito   179 WALGNIAGDGSKARDIVLEHNSVDAIIALVTNGNTQISFLRNIVWLMSNLCRNKNPAPPFNRIEP 243

  Fly   266 GLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTAALRA 330
            .:|:|:.||.:.||.||||.|||:.|::|...:|:::|:.:|...:||.||......:.|.|||:
Mosquito   244 MIPVLSALLDHEDAQVLSDACWALSYVTDDDVEKLESVVASGAVPKLVRLLGTNNPAIITPALRS 308

  Fly   331 VGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINANIFPQ 395
            |||||||:|:||..::..|||..:::||..|..||.||:.||:|||.|||:.|||.::::.||..
Mosquito   309 VGNIVTGNDKQTDAVIAANALPLLTNLLRHTKNTIVKEAAWTVSNITAGNQSQIQHVLDSGIFNV 373

  Fly   396 LMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQ-VGCVPPMCDFLTVVDSDIVQVALNALE 459
            |:.::...:||::||||||:||.|:.|:.|||..||: ...:.|.||.|...|:..|:|.|:.:.
Mosquito   374 LIDVLANGDFKSQKEAAWAVTNTTTGGSTEQIIQLVEKYPIMKPYCDLLEAKDTRTVRVVLSGVA 438

  Fly   460 NILKAGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNEEE-DSRVAPV 523
            ||.:...:.....| .....||.|.|||:|.||.|||.|||.|:..:||.||.:.|: :...||.
Mosquito   439 NIFQFASQIGGVEN-LCTLFEEIGALDKLETLQNHENEDIYQKALLLIETYFCDAEDVNPECAPK 502

  Fly   524 AGTQQFEFDPDNMPSTGFNF 543
            ......||:|....:.||:|
Mosquito   503 EVNGALEFNPTTPQNGGFSF 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	228/538 (42%)
		armadillo repeat	133..165	CDD:293788	17/31 (55%)
		armadillo repeat	173..209	CDD:293788	25/35 (71%)
		armadillo repeat	215..250	CDD:293788	10/35 (29%)
		armadillo repeat	267..292	CDD:293788	13/24 (54%)
		armadillo repeat	300..336	CDD:293788	14/35 (40%)
		armadillo repeat	342..376	CDD:293788	14/33 (42%)
		armadillo repeat	384..421	CDD:293788	16/36 (44%)
		armadillo repeat	427..461	CDD:293788	11/34 (32%)
Pen	XP_318886.3	SRP1	1..520	CDD:227396	226/536 (42%)
		armadillo repeat	109..142	CDD:293788	17/32 (53%)
		armadillo repeat	150..186	CDD:293788	25/35 (71%)
		armadillo repeat	192..228	CDD:293788	10/35 (29%)
		armadillo repeat	245..270	CDD:293788	13/24 (54%)
		armadillo repeat	278..314	CDD:293788	14/35 (40%)
		armadillo repeat	320..354	CDD:293788	14/33 (42%)
		armadillo repeat	362..395	CDD:293788	13/32 (41%)
		armadillo repeat	406..440	CDD:293788	10/33 (30%)