Protein Alignment Kap-alpha1 and Kap-alpha1

DIOPT Version :10

• Sequence 1: NP_524167.1
• Gene: Kap-alpha1 / 40160
• FlyBaseID: FBgn0024889
• Length: 543
• Species: Drosophila melanogaster
• Sequence 2: XP_315411.4
• Gene: Kap-alpha1 / 1276102
• VectorBaseID: AGAMI1_007861
• Length: 520
• Species: Anopheles gambiae
• Alignment Length: 543
• Identity: 336/543 - (61%)
• Similarity: 408/543 - (75%)
• Gaps: 26/543 - (4%)

  Fly     2 SASHKQRYKNAALDSTEMRRRREEVGIQLRKNKREQQLFKRRNVVLEPATSSTSAGVESNTDNEQ 66
            :|:|:.||||..||||||||||||.||||||.||||||.|||||               |..:|.
Mosquito     3 NATHRHRYKNVGLDSTEMRRRREEEGIQLRKQKREQQLIKRRNV---------------NVADEL 52

  Fly    67 QAADMHMADSSTGGQNEEAAGSGAQPSVINEEMIQMLFSGRENEQLEATQKFRKLLSRDPNPPIE 131
            : .|..::|.:|...|.         |:|...:||.|:|....|||.||||||:|||::|||||:
Mosquito    53 E-QDAILSDETTSTDNR---------SLIQPAVIQALYSENIEEQLVATQKFRRLLSKEPNPPID 107

  Fly   132 EVIQKGIVPQFVTFLRNSANATLQFEAAWTLTNIASGTSQQTKVVIEAGAVPIFIDLLSSPHDDV 196
            .||:..|||:.|.||.||.|:||||||||.|||||||||:||.|||.|||||||:||:.|||:||
Mosquito   108 MVIKHNIVPRLVQFLGNSENSTLQFEAAWALTNIASGTSEQTSVVIAAGAVPIFVDLMKSPHEDV 172

  Fly   197 QEQAVWALGNIAGDSPMCRDHLLGSGILEPLLHVLSNSDRITMIRNAVWTLSNLCRGKSPPADFA 261
            ||||:|||||||||||.|||.:|...:|||||||||.|.|:|:.|||||.|||:||||:||.||:
Mosquito   173 QEQAIWALGNIAGDSPECRDCVLDHDVLEPLLHVLSTSRRLTLTRNAVWALSNMCRGKNPPPDFS 237

  Fly   262 KISHGLPILARLLKYTDADVLSDTCWAIGYLSDGPNDKIQAVIDAGVCRRLVELLLHPQQNVSTA 326
            |:...||||::|:.:.|.:||.|..||:.|||||.||.||||||||.||||:|||.|...||.:|
Mosquito   238 KVEKCLPILSQLMFHNDVEVLGDAVWAVSYLSDGSNDNIQAVIDAGCCRRLIELLSHSHNNVVSA 302

  Fly   327 ALRAVGNIVTGDDQQTQVILGYNALTCISHLLHSTAETIKKESCWTISNIAAGNREQIQALINAN 391
            |||||||||||:|.|||:||..|||..|..||.||.|.::||:||||||||||||.||||.|:||
Mosquito   303 ALRAVGNIVTGNDTQTQLILNCNALPSILQLLSSTKEAVRKEACWTISNIAAGNRNQIQAAIDAN 367

  Fly   392 IFPQLMVIMQTAEFKTRKEAAWAITNATSSGTHEQIHYLVQVGCVPPMCDFLTVVDSDIVQVALN 456
            |||.::.::|.|:||||||||||||||||.||.:||.|||..||:||||:.|||:|..||.||||
Mosquito   368 IFPSIIDLLQKADFKTRKEAAWAITNATSGGTVQQIKYLVDAGCIPPMCELLTVMDPKIVTVALN 432

  Fly   457 ALENILKAGEKFQTRPNPYAITIEECGGLDKIEYLQAHENRDIYHKSFYIIEQYFGNEEEDSRVA 521
            .||||||.|::.:|:|||||:.||||.||||:|:||:|:|.|||.|:|.||::||.|::||..||
Mosquito   433 GLENILKVGDEQRTKPNPYAVMIEECYGLDKLEFLQSHQNNDIYEKAFSIIQKYFSNDDEDLAVA 497

  Fly   522 PVAGTQQFEFDPD-NMPSTGFNF 543
            |.....||:|:.| ::|..||.|
Mosquito   498 PSTDNNQFQFNADQSVPMDGFQF 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Kap-alpha1	NP_524167.1	SRP1	1..543	CDD:227396	335/541 (62%)
		armadillo repeat	133..165	CDD:293788	21/31 (68%)
		armadillo repeat	173..209	CDD:293788	28/35 (80%)
		armadillo repeat	215..250	CDD:293788	22/34 (65%)
		armadillo repeat	267..292	CDD:293788	11/24 (46%)
		armadillo repeat	300..336	CDD:293788	27/35 (77%)
		armadillo repeat	342..376	CDD:293788	20/33 (61%)
		armadillo repeat	384..421	CDD:293788	26/36 (72%)
		armadillo repeat	427..461	CDD:293788	22/33 (67%)
Kap-alpha1	XP_315411.4	SRP1	29..511	CDD:227396	301/481 (63%)
		armadillo repeat	73..98	CDD:293788	5/24 (21%)
		armadillo repeat	108..141	CDD:293788	20/32 (63%)
		armadillo repeat	149..185	CDD:293788	29/35 (83%)
		armadillo repeat	191..226	CDD:293788	24/34 (71%)
		armadillo repeat	243..268	CDD:293788	16/24 (67%)
		armadillo repeat	276..312	CDD:293788	22/35 (63%)
		armadillo repeat	318..352	CDD:293788	22/33 (67%)
		armadillo repeat	360..396	CDD:293788	26/35 (74%)
		armadillo repeat	403..437	CDD:293788	25/33 (76%)