Protein Alignment Ir76a and Grid2

DIOPT Version :10

• Sequence 1: NP_001097647.3
• Gene: Ir76a / 40157
• FlyBaseID: FBgn0260874
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_077355.2
• Gene: Grid2 / 79220
• RGDID: 68368
• Length: 1007
• Species: Rattus norvegicus
• Alignment Length: 601
• Identity: 115/601 - (19%)
• Similarity: 209/601 - (34%)
• Gaps: 151/601 - (25%)

  Fly   120 IYSIWRSLRNRFMFVYTKEFEDKKDSYLSGYIFQDQPNILVITSQYLNSSTFE--------IK-- 174
            ||.....|.|.|    .|:.||:|        :....::..|..   ||..::        ||
  Rat   327 IYDTVLLLANAF----HKKLEDRK--------WHSMASLSCIRK---NSKPWQGGRSMLETIKKG 376

  Fly   175 -TNRFVGPRNFNK---NPEPVEFYILQRFDAKGTK------------ATWETQSAMSSKM----- 218
             .|...|...|.:   ||. |.|.||      ||.            ..|...:.::..:
  Rat   377 GVNGLTGDLEFGENGGNPN-VHFEIL------GTNYGEELGRGVRKLGCWNPVTGLNGSLTDKKL 434

  Fly   219 -RNLKGREVVIGIFDY--KPFMLLDYE---KPPLYYDRFMNTTDVTIDGTDIQLMLIFCELYNCT 277
             .|::|  ||:.:...  :||:::...   ||..|            .|..|.::..........
  Rat   435 ENNMRG--VVLRVVTVLEEPFVMVSENVLGKPKKY------------QGFSIDVLDALSNYLGFN 485

  Fly   278 IQVDTSEPYDWGDIYLNASGYGLVGMILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVP 342
            .::..:..:.:|....:.:..||||.::.:|.|.|:..:.:..:....:|.|.......|..|:.
  Rat   486 YEIYVAPDHKYGSPQEDGTWNGLVGELVFKRADIGISALTITPDRENVVDFTTRYMDYSVGVLLR 550

  Fly   343 APNRLISWTLLLRPFQFVLWMCVMLCLLLESLALGITRRWEHSSVAAGNSWIS--SLRFGCISTL 405
            ...:.:.....|.||...||.|:...:||..|.:.:.            :|::  .|:.|.:::.
  Rat   551 RAEKTVDMFACLAPFDLSLWACIAGTVLLVGLLVYLL------------NWLNPPRLQMGSMTST 603

  Fly   406 KL----------FVNQSTNYVTSSYALRTVLVASYMIDIILTTVYSGGLAAILTLPTLEEAADSR 460
            .|          ||.|......::.|.|.::.|.::..:|:.:.|:..|||.||:..:|.:..|.
  Rat   604 TLYNSMWFVYGSFVQQGGEVPYTTLATRMMMGAWWLFALIVISSYTANLAAFLTITRIESSIQSL 668

  Fly   461 QRLFDHKLIWTGTSQAWITTIDERSADPVLLGLMEHYRVYDANLISAFSHTEQMGFVVER----- 520
            |.|...      |...:.|.:|.        .:.:|.|:...|.....|...||..::.|
  Rat   669 QDLSKQ------TDIPYGTVLDS--------AVYQHVRMKGLNPFERDSMYSQMWRMINRSNGSE 719

  Fly   521 ---------LQFGHLGNTELIENDALKRLKLMVDDIYFAFTV--AFVPRLW--------PHLNAY 566
                     :|....||...:.:.|:.....:.|.....:||  ....|.:        |:.:.:
  Rat   720 NNVLESQAGIQKVKYGNYAFVWDAAVLEYVAINDPDCSFYTVGNTVADRGYGIALQHGSPYRDVF 784

  Fly   567 NDFILAWHSSG-FD----KFWEWKIAAEYMNAHRQNRIVASEKTNLDIGPVKLGIDNFIGLILLW 626
            :..||....|| .|    |:|......:..::     :.|.:|..      .|.|.:..|:..:.
  Rat   785 SQRILELQQSGDMDILKHKWWPKNGQCDLYSS-----VDAKQKGG------ALDIKSLAGVFCIL 838

  Fly   627 CFGMICSLLTFLGELW 642
            ..|::.|.|..:.|.|
  Rat   839 AAGIVLSCLIAVLETW 854

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
Grid2	NP_077355.2	Interaction with CBLN1 homotrimer. /evidence=ECO:0000250|UniProtKB:O43424	24..345		7/21 (33%)
		Periplasmic_Binding_Protein_type1	28..429	CDD:471960	26/123 (21%)
		PBP2_iGluR_delta_2	440..806	CDD:270449	77/405 (19%)
		Interaction with AP4M1. /evidence=ECO:0000269|PubMed:14572453	921..991
		PDZ-binding. /evidence=ECO:0000250	1005..1007