DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76a and grid1b

DIOPT Version :9

Sequence 1:	NP_001097647.3	Gene:	Ir76a / 40157	FlyBaseID:	FBgn0260874	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_009304811.1	Gene:	grid1b / 557511	ZFINID:	ZDB-GENE-121214-84	Length:	1048	Species:	Danio rerio

Alignment Length:	739	Identity:	130/739 - (17%)
Similarity:	237/739 - (32%)	Gaps:	246/739 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 IFWHPAFDFRLETVHPMPLIIMDWHRWANRSDQDVYDYKIKEDEFEGKGIPYNDWTLRLTV---- 91
            :|.|.|.:..|.:        .|.| |. ..::::.|.:|.|......|        |:||
Zfish   238 VFIHQAVETNLAS--------KDSH-WV-FVNEEISDTEILELAHSSLG--------RMTVVRQI 284

  Fly    92 ----------AIERSH------CETFIAFQEQIPEFARYFYHASIYSIWRSLRNRFMFVYTKEFE 140
                      .:..||      |:....:.:.:.....|.|.:.:     .|.|.|.    ::.|
Zfish   285 FPLWRDSSVSCMRNSHRISSLLCDPQEGYLQSLEVSNLYLYDSVL-----MLANAFY----RKLE 340

  Fly   141 DKKDSYLSGYIFQDQPNILVITSQYLNS--STFE-IKTNRFVGPRNF-----NKNPEPVEFYILQ 197
            |:|...::..      |.:..:::..|.  |..| |:..|..|....     |.:...|:|.||
Zfish   341 DRKWHSMASL------NCIRKSTKPWNGGWSMLETIQKGRITGLTGIMDFMENGSNSHVQFEIL- 398

  Fly   198 RFDAKGTK------------ATWETQSAMSSKMR------NLKGREVVIGIFDYKPFMLLDYE-- 242
                 ||.            |||::...::..::      .::|..|.:......||:::...
Zfish   399 -----GTSFSETFGKDIKRLATWDSVHGLNGSLKESRIENGMQGVTVKVVTLLEDPFVMVAENIL 458

  Fly   243 -KPPLYYDRFMNTTDVTIDGTDIQLMLIFCELYNCTIQVDTSEPYDWGDIYLNASGYGLVGMILD 306
             :|..|            .|..|.::....::......:.......:|....|.|..|::|.:::
Zfish   459 GQPKRY------------KGFSIDVLEALAKILGFKYDIYQVADSKYGSQLSNGSWNGMIGELIN 511

  Fly   307 RRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPNRLISWTLLLRPFQFVLWMCVMLCLLL 371
            :|.|..|..:.:..|....:|.:.......|..|...|...|:...|..||...:|.|:...:.:
Zfish   512 KRADLAVSAITITPERENVVDFSKRYMDYSVGILHRKPEEKINIFSLFAPFDLAVWACIAAAIPV 576

  Fly   372 ESLALGITRRWE----------HSSVAAGNS-----WISSLRFGCISTLKLFVNQSTNYVTSSYA 421
            ..:.:.:..|.:          |.:.:..||     ||.   :|.      ||.|..:.|..|.|
Zfish   577 VGVLIFLLTRMQMLRSQNPPGAHHASSMSNSLHSAIWIV---YGA------FVQQGGDSVVGSVA 632

  Fly   422 LRTVLVASYMIDIILTTVYSGGLAAILTLPTLEEAADSRQRLFDHKLIWTGTSQAWITTIDERSA 486
            ||.|:.:.::..:|:.:.|:..|||.||:..::....:.|.|                   .|..
Zfish   633 LRIVMGSWWLFTLIVCSSYTANLAAFLTVSRMDNTIRTFQDL-------------------ARQM 678

  Fly   487 DPVLLGLMEHYRVYDANLISAFSHTEQMGFVVERLQFGHLGNTELIENDALKRLKLMVDDIYFAF 551
            | ...|.:....|||                     :.....|..:|.|:
Zfish   679 D-FAYGTVRDSAVYD---------------------YFKAKGTNPLEQDS--------------- 706

  Fly   552 TVAFVPRLWPHLNAYN--DFILAWHSSGFDK--------FWE----------------------- 583
            |.|   .||..::..|  ||.::..|.|..|        .|:
Zfish   707 TYA---ELWRTISKNNGQDFSVSSPSEGIRKAKKGPYAFLWDMAVVEYAALTDDDCTITVSGNSM 768

  Fly   584 ----WKIAAEYMNAHR----QNRIVASEKTNLDIGPVK----------------------LGIDN 618
                :.||.::.:.:|    |..:...||.:||:...|                      |.:.:
Zfish   769 SSKGYGIAMQHGSPYRDLISQKILELQEKGDLDVLKQKWWPRTGRCDLNSHSNAQPDGRSLKLHS 833

  Fly   619 FIGLILLWCFGMICSLLTFLGELW 642
            |.|:..:...|::.:.|....|:|
Zfish   834 FAGVFCILAAGLLLACLVAALEMW 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
grid1b	XP_009304811.1	PBP1_iGluR_delta_1	25..424	CDD:107387	42/224 (19%)
		ANF_receptor	36..400	CDD:279440	37/200 (19%)
		Periplasmic_Binding_Protein_Type_2	437..809	CDD:304360	81/451 (18%)
		Lig_chan	565..840	CDD:278489	59/342 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591133
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840