DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76a and grik2

DIOPT Version :9

Sequence 1:	NP_001097647.3	Gene:	Ir76a / 40157	FlyBaseID:	FBgn0260874	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	XP_021322472.1	Gene:	grik2 / 556013	ZFINID:	ZDB-GENE-080414-1	Length:	908	Species:	Danio rerio

Alignment Length:	594	Identity:	114/594 - (19%)
Similarity:	223/594 - (37%)	Gaps:	146/594 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 EQIPEFARYFYHASIYSIWRSLRNRFMFVYTKEFEDKKDSYLSGYIFQDQPNILVITSQYLNSST 170
            :|.|:........:.:..|| ..||||.:.       |:::..|.                   |
Zfish   335 QQSPQITVSSLQCNRHKPWR-FGNRFMTLI-------KEAHWDGL-------------------T 372

  Fly   171 FEIKTNRFVGPR-NFNKNPEPVEFYILQRFDAKGTKATWETQSAMS------SKMRN----LKGR 224
            ..|..||..|.| :|:.:...::...|::.      .||:..|.::      .|..|    |..|
Zfish   373 GRINFNRTNGLRTDFDLDVISLKEEGLEKI------GTWDPASGLNMTENQKGKTANVTDSLSNR 431

  Fly   225 EVVIGIFDYKPFMLLDYEKPPLY-YDRFMNTTDVTIDGTDIQLMLIFCELYNCTIQVDTSEPYDW 288
            .:|:.....:|:::......||| .|||        :|..:.|:.....:.....::...|...:
Zfish   432 SLVVSTILEEPYVMFKKSDKPLYGNDRF--------EGYCVDLLRELAAILGFGYELRLVEDGRY 488

  Fly   289 G--DIYLNASGY--GLVGMILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPN---- 345
            |  |   .:||.  |:|..::|.:.|..|..:.:.|...:.:|.:......|::.|...||
Zfish   489 GAQD---ESSGQWNGMVRELMDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNP 550

  Fly   346 RLISWTLLLRPFQFVLWMCVMLCLLLESLALGITRR-----WEH-------SSVAAGN-SWISSL 397
            .:.|:   |.|....:||.::|..|..|..|.:..|     |.:       |.|...| :.::|.
Zfish   551 GVFSF---LNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSF 612

  Fly   398 RFGCISTLKLFVNQSTNYVTSSYALRTVLVASYMIDIILTTVYSGGLAAILTLPTLEEAADS--- 459
            .||    :...:.|.:..:..:.:.|.|....:...:|:.:.|:..|||.||:..:|...||
Zfish   613 WFG----VGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADD 673

  Fly   460 --RQRLFDHKLIWTGTSQAW-----ITTIDERSADPVLLGLMEHYRVYDANLISAFSHTEQMGFV 517
              :|...::.::..|::..:     |:|.|               ::::  .:|:..|:..:..:
Zfish   674 LAKQTKIEYGVVEDGSTMTFFKKTKISTYD---------------KMWE--FMSSRRHSVMVKSI 721

  Fly   518 VERLQ------FGHLGNTELIE-----NDALKRLKLMVDDIYFAFTVAFVPRLWPHLNAYNDFIL 571
            .|.::      :..|..:..||     |..|.::..::|.  .|:.|. .|...|:.:.....||
Zfish   722 EEGIERVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDS--KAYGVG-TPMGSPYRDKITIAIL 783

  Fly   572 AWHSSG-----FDKFWEWKIAAEYMNAHRQNRIVASEKTNLDIGPVKLGIDNFIGLILLWCFGMI 631
            .....|     .:|:|......|     .:|:..::           ||:.|..|:.::...|::
Zfish   784 QLQEEGKLHMMKEKWWRGNGCPE-----EENKEASA-----------LGVQNIGGIFIVLAAGLV 832

  Fly   632 CSLLTFLGE 640
            .|:...:||
Zfish   833 LSVFVAVGE 841

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
grik2	XP_021322472.1	PBP1_iGluR_Kainate	37..414	CDD:380605	21/111 (19%)
grik2	XP_021322472.1	Periplasmic_Binding_Protein_Type_2	430..800	CDD:419667	79/407 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170591726
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840