DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76a and Nmdar1

DIOPT Version :9

Sequence 1:	NP_001097647.3	Gene:	Ir76a / 40157	FlyBaseID:	FBgn0260874	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_730940.1	Gene:	Nmdar1 / 40665	FlyBaseID:	FBgn0010399	Length:	997	Species:	Drosophila melanogaster

Alignment Length:	784	Identity:	157/784 - (20%)
Similarity:	259/784 - (33%)	Gaps:	267/784 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 FADSHATCIFWHPAFDFRLETVHPMPLIIMDWHR---WANRSDQDVYD--YKIKEDEFEGKGI-- 80
            |:|.:.     |.:|   |.||.|.      :|:   |........|.  ..|...:.:|:.|
  Fly   141 FSDKNI-----HVSF---LRTVPPY------YHQADVWLEMLSHFAYTKVIIIHSSDTDGRAILG 191

  Fly    81 --------PYNDWTLRLTVAIERSHCETFIAFQEQIPEFARYFY-----HASIYSIWRSLRNRFM 132
                    .|:|..:|.||       |..:.|:.::..|..:..     .:.:|.::.|..:..:
  Fly   192 RFQTTSQTYYDDVDVRATV-------ELIVEFEPKLESFTEHLIDMKTAQSRVYLMYASTEDAQV 249

  Fly   133 FVYTKEFEDKKDSYLSGYIFQDQPNILVITSQYLNSSTFEIKTNRFVGPRNFNKNPEPV------ 191
            .     |.|..:..::|     :.::.::|.|.|.|                |..|:.|
  Fly   250 I-----FRDAGEYNMTG-----EGHVWIVTEQALFS----------------NNTPDGVLGLQLE 288

  Fly   192 -----------EFYILQRF---------------DAKGTKATWETQSAMSS--KMRNLKG----- 223
                       ..|:|...               |...:...||:...:..  |.||:.|
  Fly   289 HAHSDKGHIRDSVYVLASAIKEMISNETIAEAPKDCGDSAVNWESGKRLFQYLKSRNITGETGQV 353

  Fly   224 ----------------------REVVIGIFDY------------------------KP------- 235
                                  ::.|:|.|.|                        ||
  Fly   354 AFDDNGDRIYAGYDVINIREQQKKHVVGKFSYDSMRAKMRMRINDSEIIWPGKQRRKPEGIMIPT 418

  Fly   236 -FMLLDYEKPPLYYDRFM-----------------NTTDVTID-----GTDIQLMLIFCELYNCT 277
             ..||..|:.|..|.|.|                 |.:|.|.:     |..|.|::...:..|.|
  Fly   419 HLRLLTIEEKPFVYVRRMGDDEFRCEPDERPCPLFNNSDATANEFCCRGYCIDLLIELSKRINFT 483

  Fly   278 IQVDTSEPYDWGDIYL-NASG--------YGLVGMILDRRNDYGVGGMYLWYEAYEYMDMTHFLG 333
            ..:..|....:|...| |.:|        .||:|.:::.|.|..|..:.:..|..||::.:....
  Fly   484 YDLALSPDGQFGHYILRNNTGAMTLRKEWTGLIGELVNERADMIVAPLTINPERAEYIEFSKPFK 548

  Fly   334 RSGVTCLVPAPNRLISWTLLLRPFQFVLWMCVMLCLLLESLALGITRRW--------EHS----- 385
            ..|:|.|...|:|..:....|:||...||:.||:.:.:.:|.|.:..|:        .||
  Fly   549 YQGITILEKKPSRSSTLVSFLQPFSNTLWILVMVSVHVVALVLYLLDRFSPFGRFKLSHSDSNEE 613

  Fly   386 -----SVAAGNSWISSLRFGC-ISTLKLFVNQSTNYVTSSYALRTVLVASYMIDIILTTVYSGGL 444
                 |.|...:|...|..|. ..|.:.|..:....|.:.:|:  ::|||          |:..|
  Fly   614 KALNLSSAVWFAWGVLLNSGIGEGTPRSFSARVLGMVWAGFAM--IIVAS----------YTANL 666

  Fly   445 AAILTL----PTLEEAADSRQRLFDHKLIWTGTSQAWITTIDERSADPVL---LGLMEHYRVYDA 502
            ||.|.|    ..|....|:|.|.....|.        ..|:...|.|...   :.|...||..:|
  Fly   667 AAFLVLERPKTKLSGINDARLRNTMENLT--------CATVKGSSVDMYFRRQVELSNMYRTMEA 723

  Fly   503 NLISAFSHTEQMGFVVERLQFGHL----GNTELIENDALKRLKLMVDDIYF---AFTVAFVPRLW 560
            |   .::..||   .::.::.|.|    .::..:|.:|.|..:|:.....|   .:.:. :.:..
  Fly   724 N---NYATAEQ---AIQDVKKGKLMAFIWDSSRLEYEASKDCELVTAGELFGRSGYGIG-LQKGS 781

  Fly   561 PHLNAYNDFILAWHSSGF----DKFWEWKIAAEYMNAHRQNRIVASEKTNLDIGPVKLGIDNFIG 621
            |..:|....||.:|.|||    ||.|       ..:.|.|......|||     |..||:.|..|
  Fly   782 PWTDAVTLAILEFHESGFMEKLDKQW-------IFHGHVQQNCELFEKT-----PNTLGLKNMAG 834

  Fly   622 LILL 625
            :.:|
  Fly   835 VFIL 838

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
Nmdar1	NP_730940.1	PBP1_iGluR_NMDA_NR1	12..405	CDD:107374	47/310 (15%)
		ANF_receptor	58..371	CDD:279440	43/276 (16%)
		PBP2_iGluR_NMDA_Nr1	417..818	CDD:270437	99/434 (23%)
		HisJ	451..>558	CDD:223904	25/106 (24%)
		Periplasmic_Binding_Protein_Type_2	<516..651	CDD:304360	31/134 (23%)
		Lig_chan	575..838	CDD:278489	70/301 (23%)
		CaM_bdg_C0	854..882	CDD:287524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463041
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840