DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76a and Gria4

DIOPT Version :9

Sequence 1:	NP_001097647.3	Gene:	Ir76a / 40157	FlyBaseID:	FBgn0260874	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001106655.1	Gene:	Gria4 / 29629	RGDID:	61863	Length:	902	Species:	Rattus norvegicus

Alignment Length:	387	Identity:	80/387 - (20%)
Similarity:	139/387 - (35%)	Gaps:	80/387 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   299 GLVGMILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPNR----LISWTLLLRPFQF 359
            |:||.::..:.:..:..:.:.....|.:|.:......|::.::..|.:    :.|:   |.|..:
  Rat   484 GMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSF---LDPLAY 545

  Fly   360 VLWMCVMLCLLLESLALGITRR-----WEHSSVAAGNSWISSL---RFGCIS----TLKLFVNQS 412
            .:|||::...:..|:.|.:..|     |.......|....|..   .||..:    :|..|:.|.
  Rat   546 EIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQG 610

  Fly   413 TNYVTSSYALRTVLVASYMIDIILTTVYSGGLAAILTLPTLEEAADSRQRLFDHKLIWTGTSQAW 477
            .:....|.:.|.|....:...:|:.:.|:..|||.||:..:....:|.:.|.....|..||..:.
  Rat   611 CDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSG 675

  Fly   478 IT---------TIDE------RSADPVLLGLMEHYRVYDANLISAFSHTEQMGFVVERLQFGH-- 525
            .|         .:.|      |||:|                 |.|:.|...|....|...|.
  Rat   676 STKEFFRRSKIAVYEKMWTYMRSAEP-----------------SVFTRTTAEGVARVRKSKGKFA 723

  Fly   526 --LGNT--ELIEN----DALKRLKLMVDDIYFAFTVAFVPRLWPHLNAYNDFILAWHSSG-FDKF 581
              |.:|  |.||.    |.:|....:....|...|    |:.....||.|..:|..:..| .||.
  Rat   724 FLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGVAT----PKGSSLRNAVNLAVLKLNEQGLLDKL 784

  Fly   582 ---WEWKIAAEYMNAHRQNRIVASEKTNLDIGPVKLGIDNFIGLILLWCFGMICSLLTFLGE 640
               | |....|..:....::    :||:      .|.:.|..|:..:...|:..::|..|.|
  Rat   785 KNKW-WYDKGECGSGGGDSK----DKTS------ALSLSNVAGVFYILVGGLGLAMLVALIE 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
Gria4	NP_001106655.1	PBP1_iGluR_AMPA_GluR4	28..398	CDD:107383
		ANF_receptor	39..380	CDD:279440
		PBP2_iGluR_AMPA_GluR4	414..795	CDD:270445	70/335 (21%)
		Lig_chan	546..825	CDD:278489	66/310 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350114
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840