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Protein Alignment Ir76a and GRIN2D

DIOPT Version :9

Sequence 1:	NP_001097647.3	Gene:	Ir76a / 40157	FlyBaseID:	FBgn0260874	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_000827.2	Gene:	GRIN2D / 2906	HGNCID:	4588	Length:	1336	Species:	Homo sapiens

Alignment Length:	556	Identity:	113/556 - (20%)
Similarity:	181/556 - (32%)	Gaps:	199/556 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 TWETQSAMSSKMRNLK-------GR---------EVVIGIFDYKPFMLLDYEKPPLYYDRFMNTT 255
            |||...:...:...||       ||         .:.:...:.:||::::...|
Human   397 TWEVVGSWEQQTLRLKYPLWSRYGRFLQPVDDTQHLTVATLEERPFVIVEPADP----------- 450

  Fly   256 DVTIDGTDIQLMLIFCELYNCTIQVDT--SEPYDWG--------------------------DIY 292
               |.||.|:      :...|..|::.  |.|.|..                          |:|
Human   451 ---ISGTCIR------DSVPCRSQLNRTHSPPPDAPRPEKRCCKGFCIDILKRLAHTIGFSYDLY 506

  Fly   293 LNASG----------YGLVGMILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPNRL 347
            |..:|          .|::|.:..:|.|..:|.:.:..|..|.:|.:.....:|::.:|...|..
Human   507 LVTNGKHGKKIDGVWNGMIGEVFYQRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGT 571

  Fly   348 ISWTLLLRPFQFVLW-MCVMLCLLL-----------------ESLALGITRRWEHSSVAAGNS-W 393
            :|.:..|.|:...:| |..::||.:                 .|||.|  :|...|:...|.| |
Human   572 VSPSAFLEPYSPAVWVMMFVMCLTVVAVTVFIFEYLSPVGYNRSLATG--KRPGGSTFTIGKSIW 634

  Fly   394 ISSLRFGCISTLKLFVNQSTNYV----TSSYALRTVLVASYMIDIILTTVYSGGLAAILTLPTLE 454
            :         ...|..|.|....    |:|..:  |||.::...|.|.: |:..|||.:   ..|
Human   635 L---------LWALVFNNSVPVENPRGTTSKIM--VLVWAFFAVIFLAS-YTANLAAFM---IQE 684

  Fly   455 EAADSRQRLFDHKL---------IWTGTSQAWITTIDERSADPVLLGLMEHYR------------ 498
            |..|:...|.|.|.         :..||.....|..:.||..|.:...|..|.
Human   685 EYVDTVSGLSDRKFQRPQEQYPPLKFGTVPNGSTEKNIRSNYPDMHSYMVRYNQPRVEEALTQLK 749

  Fly   499 -------VYDANLISAFSHTEQ--------MGFVVERLQFG---HLGNTELIENDALKRLKLMVD 545
                   :|||.:::..:..::        .|.|.....:|   |.|:......| |..|:.:.|
Human   750 AGKLDAFIYDAAVLNYMARKDEGCKLVTIGSGKVFATTGYGIALHKGSRWKRPID-LALLQFLGD 813

  Fly   546 DIYFAFTVAFVPRLWPHLNAYNDFILAWHSSGFDKFWEWKIAAEYMNAHRQNRIVASEKTNLDIG 610
            |     .:..:.|||.....:||.|                  |.|::
Human   814 D-----EIEMLERLWLSGICHNDKI------------------EVMSS----------------- 838

  Fly   611 PVKLGIDNFIGLILLWCFGMICSLLTFLGE---LWR 643
              ||.|||..|:..:....|..|||.|..|   .||
Human   839 --KLDIDNMAGVFYMLLVAMGLSLLVFAWEHLVYWR 872

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.