Protein Alignment Ir76a and GRIN2C

DIOPT Version :10

• Sequence 1: NP_001097647.3
• Gene: Ir76a / 40157
• FlyBaseID: FBgn0260874
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_054171851.1
• Gene: GRIN2C / 2905
• HGNCID: 4587
• Length: 1265
• Species: Homo sapiens
• Alignment Length: 632
• Identity: 124/632 - (19%)
• Similarity: 213/632 - (33%)
• Gaps: 194/632 - (30%)

  Fly   115 FYHASIYSIWRSLRNRFMFVYTKEFEDKKDSYLSGYIFQDQPNILVITSQYLNSSTFEIKTNRFV 179
            ||...:...|..          ::|......||.      ||.::||.   ||.........|:.
Human   331 FYRHLLNVTWEG----------RDFSFSPGGYLV------QPTMVVIA---LNRHRLWEMVGRWE 376

  Fly   180 GPRNFNKNPEPVEFYILQRFDAKGTKATWETQSAMSSKMRNLKGREVVIGIFDYKPFMLLDYEKP 244
            ....:.|.|                  .|...||  |....:..|.:.:...:.:||::::...|
Human   377 HGVLYMKYP------------------VWPRYSA--SLQPVVDSRHLTVATLEERPFVIVESPDP 421

  Fly   245 ------PLYYDRFMNT------TDVTIDGTDI-QLMLIFCELYNCTIQVDTSEPYDWG-DIYLNA 295
                  |       ||      ::.|....|: ....:.|:.:...|....:....:. |:||..
Human   422 GTGGCVP-------NTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVT 479

  Fly   296 SG----------YGLVGMILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPNRLISW 350
            :|          .|::|.:..:|.|..:|.:.:..|..|.:|.:.....:|::.:|...|..:|.
Human   480 NGKHGKRVRGVWNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSP 544

  Fly   351 TLLLRPFQFVLW-MCVMLCLLLESLAL-------------GITRRWEHSSVA--AGNS-WISSLR 398
            :..|.|:...:| |..::||.:.::.:             .:||..:....|  .|.| |:
Human   545 SAFLEPYSPAVWVMMFVMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWL---- 605

  Fly   399 FGCISTLKLFVNQSTNYV----TSSYALRTVLVASYMIDIILTTVYSGGLAAILTLPTLEEAADS 459
                 ...|..|.|....    |:|..:  |||.::...|.|.: |:..|||.:   ..|:..|:
Human   606 -----LWALVFNNSVPIENPRGTTSKIM--VLVWAFFAVIFLAS-YTANLAAFM---IQEQYIDT 659

  Fly   460 RQRLFDHK-LIWTGTSQAW------ITTIDERSAD---PVLLGLMEHYRVYDANLISAF--SHTE 512
            ...|.|.| |....|..||      .:...:|..|   |...|.:.:... :.|:.|.:  .||.
Human   660 VSGLSDKKSLHLENTGVAWTAFKTFCSDYFQRPQDQYPPFRFGTVPNGST-ERNIRSNYRDMHTH 723

  Fly   513 QMGFVVERLQFGHLGNTELIENDALKRLKLMVDDIYFAFTVAFVPRLWPHLNA--YNDFIL---- 571
            .:.|           |...:| |||..||:       ......|||   .|:|  |:..:|
Human   724 MVKF-----------NQRSVE-DALTSLKM-------GSEAQPVPR---KLDAFIYDAAVLNYMA 766

  Fly   572 ---------------AWHSSGF------DKFWE----------------WKIAAEYMNAHRQNRI 599
                           .:.::|:      |..|:                .|:...:::...||
Human   767 GKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWKRAIDLALLQFLGDGETQKLETVWLSGICQN-- 829

  Fly   600 VASEKTNLDIGPVKLGIDNFIGLILLWCFGMICSLLTFLGE---LWR 643
               ||.  ::...||.|||..|:..:....|..:||.|..|   .|:
Human   830 ---EKN--EVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVYWK 871

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
GRIN2C	XP_054171851.1	PBP1_iGluR_NMDA_NR2	28..384	CDD:380601	13/71 (18%)
		PBP2_iGluR_NMDA_Nr2	400..829	CDD:270436	89/473 (19%)
		NMDAR2_C	866..>941	CDD:463148	1/6 (17%)