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Protein Alignment Ir76a and GRIN2B

DIOPT Version :9

Sequence 1:	NP_001097647.3	Gene:	Ir76a / 40157	FlyBaseID:	FBgn0260874	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_000825.2	Gene:	GRIN2B / 2904	HGNCID:	4586	Length:	1484	Species:	Homo sapiens

Alignment Length:	647	Identity:	125/647 - (19%)
Similarity:	234/647 - (36%)	Gaps:	173/647 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 IPYNDW------TLRLTVAIERSHCETFIAFQEQIPEFARYFYHASIYSIWRS-LRNRFMFVYTK 137
            :.|::|      .:|..:||..:.....::....|||.....|:.....|::| :.||::...|
Human   280 VSYDEWDYGLPARVRDGIAIITTAASDMLSEHSFIPEPKSSCYNTHEKRIYQSNMLNRYLINVT- 343

  Fly   138 EFEDKKDSYL-SGYIFQDQPNILVITSQYLNSSTFEIKTNRFVGPRNFNKNPEPVEFYILQRFDA 201
             ||.:..|:. .||  |..|.:::|   .||.   |.|..| ||  .:......:::|:..|
Human   344 -FEGRNLSFSEDGY--QMHPKLVII---LLNK---ERKWER-VG--KWKDKSLQMKYYVWPR--- 393

  Fly   202 KGTKATWETQSAMSSKMRNLKGREVVIGIFDYKPFMLLDYEKPPLYYDRFMNTTD-----VTIDG 261
                        |..:....:...:.|...:..||:::: ...||......||..     ||.:.
Human   394 ------------MCPETEEQEDDHLSIVTLEEAPFVIVE-SVDPLSGTCMRNTVPCQKRIVTENK 445

  Fly   262 TDIQLMLI------FCELYNCTIQVDTSEPYDWGDIYL----------NASGYGLVGMILDRRND 310
            ||.:...|      ||  .:...::..|..:.: |:||          |.:..|::|.::.:|..
Human   446 TDEEPGYIKKCCKGFC--IDILKKISKSVKFTY-DLYLVTNGKHGKKINGTWNGMIGEVVMKRAY 507

  Fly   311 YGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPNRLISWTLLLRPFQFVLWMCVMLCLLLESLA 375
            ..||.:.:..|..|.:|.:.....:|::.:|...|..:|.:..|.||...:|:.:.:.||:.|..
Human   508 MAVGSLTINEERSEVVDFSVPFIETGISVMVSRSNGTVSPSAFLEPFSADVWVMMFVMLLIVSAV 572

  Fly   376 ----------LGITRRWEHSSVAAGNS-------WISSLRFGCISTLKLFVNQSTNYVTSSYALR 423
                      :|..|.........|.|       |   |.:|      |..|.|...........
Human   573 AVFVFEYFSPVGYNRCLADGREPGGPSFTIGKAIW---LLWG------LVFNNSVPVQNPKGTTS 628

  Fly   424 TVLVASY-MIDIILTTVYSGGLAAILTLPTLEEAADSRQRLFDHKL--------------IWTGT 473
            .::|:.: ...:|....|:..|||.:   ..||..|....|.|.|.              :..|:
Human   629 KIMVSVWAFFAVIFLASYTANLAAFM---IQEEYVDQVSGLSDKKFQRPNDFSPPFRFGTVPNGS 690

  Fly   474 SQ-----------AWITTIDERSADPVLL----GLMEHYRVYDANLISAFSHTEQ--------MG 515
            ::           |::...::|..|..||    |.::.: :|||.:::..:..::        .|
Human   691 TERNIRNNYAEMHAYMGKFNQRGVDDALLSLKTGKLDAF-IYDAAVLNYMAGRDEGCKLVTIGSG 754

  Fly   516 FVVERLQFGHLGNTELIENDA--LKRLKLMVDDIYFAFTVAFVPRLWPHLNAYNDFILAWHSSGF 578
            .|     |...|....|:.|:  .:::.|.:..::....:..:..||.....:|:
Human   755 KV-----FASTGYGIAIQKDSGWKRQVDLAILQLFGDGEMEELEALWLTGICHNE---------- 804

  Fly   579 DKFWEWKIAAEYMNAHRQNRIVASEKTNLDIGPVKLGIDNFIGLILLWCFGMICSLLTFLGE 640
                             :|.:::|:          |.|||..|:..:....|..||:||:.|
Human   805 -----------------KNEVMSSQ----------LDIDNMAGVFYMLGAAMALSLITFICE 839

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.