Protein Alignment Ir76a and GRIK5

DIOPT Version :10

• Sequence 1: NP_001097647.3
• Gene: Ir76a / 40157
• FlyBaseID: FBgn0260874
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: XP_011525167.1
• Gene: GRIK5 / 2901
• HGNCID: 4583
• Length: 982
• Species: Homo sapiens
• Alignment Length: 683
• Identity: 122/683 - (17%)
• Similarity: 206/683 - (30%)
• Gaps: 256/683 - (37%)

  Fly    40 RLETVHPMPLIIMDWHRWANRSDQDVYDYKIKED------EFEGKGIPYNDWTLRLTVAIERSHC 98
            |.:.:...||.....:.|.:.:....|...::.|      ||..||...| :|||:.....:.|.
Human   323 RSQEIGVKPLACTSANIWPHGTSLMNYLRMVEYDGLTGRVEFNSKGQRTN-YTLRILEKSRQGHR 386

  Fly    99 ETFIAFQEQIPEFARYFYHASIYSIWRSLRNRFMFVYTKEFEDKKDSYLSGYIFQDQPNILVITS 163
            |                     ..:|.|.|...|...|.:                     :..|
Human   387 E---------------------IGVWYSNRTLAMNATTLD---------------------INLS 409

  Fly   164 QYLNSSTFEIKTNRFVGPRNFNKNPEPVEFYILQR--FDAKGTKATWETQSAMSSKMRNLKGREV 226
            |.|.:.|..:.|        ..:||     |:::|  |.|                   |.|.|
Human   410 QTLANKTLVVTT--------ILENP-----YVMRRPNFQA-------------------LSGNE- 441

  Fly   227 VIGIFDYKPFMLLDYEKPPLYYDRFMNTTDVTIDGTDIQLMLIFCELYNCTIQVDTSEPYDWGDI 291
                                   ||        :|..:.::....||.....::...|...:|..
Human   442 -----------------------RF--------EGFCVDMLRELAELLRFRYRLRLVEDGLYGAP 475

  Fly   292 YLNASGYGLVGMILDRRN-DYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPA-PNRLISWTLLL 354
            ..|.|..|:||.:::|:. |..|....:..|..:.:|.:......|::.|... ..|...:...|
Human   476 EPNGSWTGMVGELINRQKADLAVAAFTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFL 540

  Fly   355 RPFQFVLWMCVMLCLLLESLALGITRR-----W--EHSSVAA-----------GNS-WISSLRFG 400
            .||...:|:.::|..|..|..|.:..|     |  .|..:.|           ||| |.
Human   541 DPFSPAVWLFMLLAYLAVSCVLFLAARLSPYEWYNPHPCLRARPHILENQYTLGNSLWF------ 599

  Fly   401 CISTLKLFVNQSTNYVTSSYALRTVLVASYMIDIILTTVYSGGLAAILTLPTLEEAADSRQRLFD 465
               .:..|:.|.:..:..:.:.|.|....:...:|:.:.|:..|||.||:..:|...:|...|.|
Human   600 ---PVGGFMQQGSEIMPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMEVPVESADDLAD 661

  Fly   466 HKLIWTGTSQAWIT-------------------------------------TIDERSADPVLLGL 493
            ...|..||..|..|                                     .::.|.|..:...:
Human   662 QTNIEYGTIHAGSTMTFFQNSRYQTYQRMWNYMQSKQPSVFVKSTEEGIARVLNSRYAFLLESTM 726

  Fly   494 MEHYRVYDANLISAFSHTEQMGFVVERLQFG---HLGN----------TELIENDALKRLKLMVD 545
            .|::|..:.||       .|:|.:::...:|   .||:          .:|.||:.|:.||
Human   727 NEYHRRLNCNL-------TQIGGLLDTKGYGIGMPLGSPFRDEITLAILQLQENNRLEILK---- 780

  Fly   546 DIYFAFTVAFVPRLWPHLNAYNDFILAWHSSGFDKFWEWKIAAEYMNAHRQNRIVASEKTNLDIG 610
                        |.|            |......|          ...||..
Human   781 ------------RKW------------WEGGRCPK----------EEDHRAK------------- 798

  Fly   611 PVKLGIDNFIGLILLWCFGMICSLLTFLGE-LW 642
              .||::|..|:.::...|:|.::...:.| :|
Human   799 --GLGMENIGGIFIVLICGLIIAVFVAVMEFIW 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
GRIK5	XP_011525167.1	PBP1_iGluR_Kainate_KA1_2	23..401	CDD:380616	20/99 (20%)
		Periplasmic_Binding_Protein_Type_2	414..785	CDD:473866	86/478 (18%)