Protein Alignment Ir76a and GRIK4

DIOPT Version :10

• Sequence 1: NP_001097647.3
• Gene: Ir76a / 40157
• FlyBaseID: FBgn0260874
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_055434.2
• Gene: GRIK4 / 2900
• HGNCID: 4582
• Length: 956
• Species: Homo sapiens
• Alignment Length: 612
• Identity: 112/612 - (18%)
• Similarity: 207/612 - (33%)
• Gaps: 181/612 - (29%)

  Fly   119 SIYSIWRSLR--NRFMFVYTKEFEDKKDSYLSGYIFQDQPNILVITSQYLNSSTFEIKTNRFVGP 181
            ::|::..:::  ||     ::|...|..|..|..|:|...:::    .||..    ::.....|.
Human   311 AVYAVVTAVQELNR-----SQEIGVKPLSCGSAQIWQHGTSLM----NYLRM----VELEGLTGH 362

  Fly   182 RNFNKNPEPVEFYI-LQRFDAKGTK--ATWETQSAMSSKMR--------NLKGREVVIGIFDYKP 235
            ..||...:...:.: :.:|...|.:  ..|.....:|....        .|....:|:......|
Human   363 IEFNSKGQRSNYALKILQFTRNGFRQIGQWHVAEGLSMDSHLYASNISDTLFNTTLVVTTILENP 427

  Fly   236 FMLLDYEKPPLY-YDRFMNTTDVTIDGTDIQLMLIFCEL--YNCTIQVDTSEPYDWGDIYLNASG 297
            :::|......:. .||:        :|..:.::....|:  :|..|::.....|  |....|.:.
Human   428 YLMLKGNHQEMEGNDRY--------EGFCVDMLKELAEILRFNYKIRLVGDGVY--GVPEANGTW 482

  Fly   298 YGLVGMILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPA-PNRLISWTLLLRPFQFVL 361
            .|:||.::.|:.|..|.|:.:..|..:.:|.:......|::.|... ..|...:...|.||...:
Human   483 TGMVGELIARKADLAVAGLTITAEREKVIDFSKPFMTLGISILYRVHMGRKPGYFSFLDPFSPGV 547

  Fly   362 WMCVMLCLLLESLALGITRR-----W--EH-----------SSVAAGNS-WISSLRFGCISTLKL 407
            |:.::|..|..|..|.:..|     |  .|           :..:.||| |.         .:..
Human   548 WLFMLLAYLAVSCVLFLVARLTPYEWYSPHPCAQGRCNLLVNQYSLGNSLWF---------PVGG 603

  Fly   408 FVNQSTNYVTSSYALRTVLVASYMIDIILTTVYSGGLAAILTLPTLEEAADSRQRLFDHKLIWTG 472
            |:.|.:.....:.:.|.|....:...:|:.:.|:..|||.||:..::...:|...|.|...|..|
Human   604 FMQQGSTIAPRALSTRCVSGVWWAFTLIIISSYTANLAAFLTVQRMDVPIESVDDLADQTAIEYG 668

  Fly   473 T------------------SQAW-----------ITTIDE------RSADPVLL--GLMEHYRVY 500
            |                  .:.|           :.:.:|      .|....||  .:.|:||..
Human   669 TIHGGSSMTFFQNSRYQTYQRMWNYMYSKQPSVFVKSTEEGIARVLNSNYAFLLESTMNEYYRQR 733

  Fly   501 DANLISAFSHTEQMGFVVERLQFG-------------HLGNTELIENDALKRLKLMVDDIYFAFT 552
            :.||       .|:|.:::...:|             .|...:|.||:.|:.||
Human   734 NCNL-------TQIGGLLDTKGYGIGMPVGSVFRDEFDLAILQLQENNRLEILK----------- 780

  Fly   553 VAFVPRLWPHLNAYNDFILAWHSSGFDKFWE-WKIAAEYMNAHRQNRIVASEKTNLDIGPVKLGI 616
                 |.|                     || .|...|  ..||..               .||:
Human   781 -----RKW---------------------WEGGKCPKE--EDHRAK---------------GLGM 802

  Fly   617 DNFIGLILLWCFGMICSL-LTFLGELW 642
            :|..|:.::...|:|.:: :..|..||
Human   803 ENIGGIFVVLICGLIVAIFMAMLEFLW 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
GRIK4	NP_055434.2	PBP1_iGluR_Kainate_KA1_2	24..402	CDD:380616	18/103 (17%)
		PBP2_iGluR_kainate_KA1	415..785	CDD:270442	78/432 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	863..889
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	931..956