DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ir76a and GRIK3

DIOPT Version :9

Sequence 1:	NP_001097647.3	Gene:	Ir76a / 40157	FlyBaseID:	FBgn0260874	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_000822.2	Gene:	GRIK3 / 2899	HGNCID:	4581	Length:	919	Species:	Homo sapiens

Alignment Length:	488	Identity:	91/488 - (18%)
Similarity:	170/488 - (34%)	Gaps:	142/488 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 NLKGREVVIGIFDYKPFMLLDYEKPPLY-YDRFMNTTDVTIDGTDIQLMLIFCELYNCTIQVDTS 283
            :|..|.:::.....:||::.......|| .|||        :|..|.|:.....:...:.::...
Human   430 SLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRF--------EGYCIDLLKELAHILGFSYEIRLV 486

  Fly   284 EPYDWGDIYLNASGYGLVGMILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPN--- 345
            |...:|.........|:|..::|.:.|..|..:.:.:...:.:|.:......||:.|...||
Human   487 EDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTN 551

  Fly   346 -RLISWTLLLRPFQFVLWMCVMLCLLLESLALGITRRWE-------H-----SSVAAGN-SWISS 396
             .:.|:   |.|....:||.|:|..|..|..|.:..|:.       |     |.|...| :.::|
Human   552 PSVFSF---LNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNS 613

  Fly   397 LRFGCISTLKLFVNQSTNYVTSSYALRTVLVASYMIDIILTTVYSGGLAAILTLPTLEEAADS-- 459
            ..||..|.::    |.:..:..:.:.|.:....:...:|:.:.|:..|||.||:..:|...||
Human   614 FWFGMGSLMQ----QGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSAD 674

  Fly   460 ---RQRLFDHKLIWTGTSQAW-----ITTIDER-----------------------SADPVLL-- 491
               :|...::..:..|.:..:     |:|.::.                       :||..||
Human   675 DLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLME 739

  Fly   492 -GLMEHYRVYDANLISAFSHTEQMGFVVERLQFG---HLGN----------TELIENDALKRLKL 542
             ..:|:....:.||       .|:|.:::...:|   .:|:          .:|.|.|.|..:|
Human   740 STTIEYVTQRNCNL-------TQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMK- 796

  Fly   543 MVDDIYFAFTVAFVPRLWPHLNAYNDFILAWHSSGFDKFWEWKIAAEYMNAHRQNRIVASEKTNL 607
                           ..|            |..||                       ..|:.|.
Human   797 ---------------EKW------------WRGSG-----------------------CPEEENK 811

  Fly   608 DIGPVKLGIDNFIGLILLWCFGMICSLLTFLGE 640
            :..  .|||....|:.::...|::.|:|..:||
Human   812 EAS--ALGIQKIGGIFIVLAAGLVLSVLVAVGE 842

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
GRIK3	NP_000822.2	PBP1_iGluR_Kainate_GluR5_7	34..417	CDD:107388
		ANF_receptor	55..398	CDD:279440
		PBP2_iGluR_Kainate_GluR7	433..801	CDD:270441	76/417 (18%)
		Lig_chan	564..832	CDD:278489	58/331 (18%)
		Glutamate binding. /evidence=ECO:0000250	690..692		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156183
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840