DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76a and GRIK2

DIOPT Version :9

Sequence 1:NP_001097647.3 Gene:Ir76a / 40157 FlyBaseID:FBgn0260874 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_068775.1 Gene:GRIK2 / 2898 HGNCID:4580 Length:908 Species:Homo sapiens


Alignment Length:496 Identity:97/496 - (19%)
Similarity:176/496 - (35%) Gaps:120/496 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   207 TWETQSAM----SSKMR------NLKGREVVIGIFDYKPFMLLDYEKPPLY-YDRFMNTTDVTID 260
            ||:..|.:    |.|.:      :|..|.:::.....:|::|......||| .|||        :
Human   404 TWDPASGLNMTESQKGKPANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRF--------E 460

  Fly   261 GTDIQLMLIFCELYNCTIQVDTSEPYDWG---DIYLNASGYGLVGMILDRRNDYGVGGMYLWYEA 322
            |..|.|:.....:...|.::...|...:|   |  .|....|:|..::|.:.|..|..:.:.|..
Human   461 GYCIDLLRELSTILGFTYEIRLVEDGKYGAQDD--ANGQWNGMVRELIDHKADLAVAPLAITYVR 523

  Fly   323 YEYMDMTHFLGRSGVTCLVPAPN----RLISWTLLLRPFQFVLWMCVMLCLLLESLALGITRR-- 381
            .:.:|.:......|::.|...||    .:.|:   |.|....:||.::|..|..|..|.:..|  
Human   524 EKVIDFSKPFMTLGISILYRKPNGTNPGVFSF---LNPLSPDIWMYILLAYLGVSCVLFVIARFS 585

  Fly   382 ---WEH-------SSVAAGN-SWISSLRFGCISTLKLFVNQSTNYVTSSYALRTVLVASYMIDII 435
               |.:       |.|...| :.::|..||    :...:.|.:..:..:.:.|.|....:...:|
Human   586 PYEWYNPHPCNPDSDVVENNFTLLNSFWFG----VGALMQQGSELMPKALSTRIVGGIWWFFTLI 646

  Fly   436 LTTVYSGGLAAILTLPTLEEAADSRQRLFDHKLIWTGTSQAWITTIDERSADPVLLGLMEHYRVY 500
            :.:.|:..|||.||:..:|...||...|.....|..|..:           |...:...:..::.
Human   647 IISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVE-----------DGATMTFFKKSKIS 700

  Fly   501 DANLISAFSHTEQMGFVVERLQFGHLGNTELIENDALKRLKLMVDDIYF---AFTVAFV------ 556
            ..:.:.||..:.:...:|:       .|.|.|:       :::..|..|   :.|:.||      
Human   701 TYDKMWAFMSSRRQSVLVK-------SNEEGIQ-------RVLTSDYAFLMESTTIEFVTQRNCN 751

  Fly   557 -----------------PRLWPHLNAYNDFILAWHSSG-----FDKFWEWKIAAEYMNAHRQNRI 599
                             |...|:.:.....||.....|     .:|:|            |.|..
Human   752 LTQIGGLIDSKGYGVGTPMGSPYRDKITIAILQLQEEGKLHMMKEKWW------------RGNGC 804

  Fly   600 VASEKTNLDIGPVKLGIDNFIGLILLWCFGMICSLLTFLGE 640
            ...|.....    .||:.|..|:.::...|::.|:...:||
Human   805 PEEESKEAS----ALGVQNIGGIFIVLAAGLVLSVFVAVGE 841

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir76aNP_001097647.3 None
GRIK2NP_068775.1 PBP1_iGluR_Kainate 37..414 CDD:380605 3/9 (33%)
Periplasmic_Binding_Protein_Type_2 430..800 CDD:419667 80/423 (19%)
Glutamate binding. /evidence=ECO:0000250|UniProtKB:P42260 516..518 0/1 (0%)