back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ir76a and GRIK1

DIOPT Version :9

Sequence 1:	NP_001097647.3	Gene:	Ir76a / 40157	FlyBaseID:	FBgn0260874	Length:	646	Species:	Drosophila melanogaster
Sequence 2:	NP_001317923.1	Gene:	GRIK1 / 2897	HGNCID:	4579	Length:	949	Species:	Homo sapiens

Alignment Length:	588	Identity:	111/588 - (18%)
Similarity:	212/588 - (36%)	Gaps:	156/588 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 WRSLRNRFMFVYTKEFEDKKDSYLSGYIFQDQPN---------ILVITSQYLNSSTFEIKTNRF- 178
            || |..|||.:    .::.:...|:|:|..::.|         |:.:..:....:..|:..:.:
Human   354 WR-LGPRFMNL----IKEARWDGLTGHITFNKTNGLRKDFDLDIISLKEEGTEKAAGEVSKHLYK 413

  Fly   179 ----VGPRNFNKNPEPVEFYILQRFDAKGTKATWETQSAMSSKMRNLKGREVVIGIFDYKPFMLL 239
                :|..|.|..        |...|:...|::..|.|        |..|.:::.....:|:::.
Human   414 VWKKIGIWNSNSG--------LNMTDSNKDKSSNITDS--------LANRTLIVTTILEEPYVMY 462

  Fly   240 DYEKPPLY-YDRFMNTTDVTIDGTDIQLML----IFCELYNCTIQVD-----TSEPYDWGDIYLN 294
            .....||| .|||        :|..:.|:.    |...:|:..:..|     .::..:|.
Human   463 RKSDKPLYGNDRF--------EGYCLDLLKELSNILGFIYDVKLVPDGKYGAQNDKGEWN----- 514

  Fly   295 ASGYGLVGMILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPN----RLISWTLLLR 355
                |:|..::|.|.|..|..:.:.|...:.:|.:......|::.|...||    .:.|:   |.
Human   515 ----GMVKELIDHRADLAVAPLTITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSF---LN 572

  Fly   356 PFQFVLWMCVMLCLLLESLALGITRR-----WEH-------SSVAAGN-SWISSLRFGCISTLKL 407
            |....:||.|:|..|..|..|.:..|     |.:       |.|...| :.::|..||    :..
Human   573 PLSPDIWMYVLLACLGVSCVLFVIARFTPYEWYNPHPCNPDSDVVENNFTLLNSFWFG----VGA 633

  Fly   408 FVNQSTNYVTSSYALRTVLVASYMIDIILTTVYSGGLAAILTLPTLEEAADS------------- 459
            .:.|.:..:..:.:.|.|....:...:|:.:.|:..|||.||:..:|...||
Human   634 LMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYG 698

  Fly   460 ------------RQRLFDHKLIWTGTSQAWITTIDERSADPVLLGLMEHYRVYDANLISAFSHTE 512
                        :.::..::.:|...|....|.:...|.:.:...|...|    |.|:.:.|
Human   699 AVRDGSTMTFFKKSKISTYEKMWAFMSSRQQTALVRNSDEGIQRVLTTDY----ALLMESTS--- 756

  Fly   513 QMGFVVERLQFGHLGNTELIENDALKRLKLMVDDIYFAFTVAFVPRLWPHLNAYNDFILAWHSSG 577
             :.:|.:|             |..|.::..::|...:.   ...|...|:.:.....||.....|
Human   757 -IEYVTQR-------------NCNLTQIGGLIDSKGYG---VGTPIGSPYRDKITIAILQLQEEG 804

  Fly   578 -----FDKFWEWKIAAEYMNAHRQNRIVASEKTNLDIGPVKLGIDNFIGLILLWCFGMICSLLTF 637
                 .:|:|            |.|.  ..|:.|.:..  .||::|..|:.::...|::.|:...
Human   805 KLHMMKEKWW------------RGNG--CPEEDNKEAS--ALGVENIGGIFIVLAAGLVLSVFVA 853

  Fly   638 LGE 640
            :||
Human   854 IGE 856

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.