DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76a and GRIA2

DIOPT Version :9

Sequence 1:NP_001097647.3 Gene:Ir76a / 40157 FlyBaseID:FBgn0260874 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_000817.5 Gene:GRIA2 / 2891 HGNCID:4572 Length:883 Species:Homo sapiens


Alignment Length:671 Identity:119/671 - (17%)
Similarity:225/671 - (33%) Gaps:215/671 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MENLLVESYYFSTVLSFFAQQF---------FADSHAT------CIFWHPAF---DFRLETVHPM 47
            ::||.|.:.:  .|.:.|..||         |.|..:.      |...|.:|   .|..:..||.
Human    62 IDNLEVANSF--AVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPF 124

  Fly    48 P-----------LIIMDWHRWANRSDQDVYDY--------------------------------K 69
            .           |.::::::|    |:..|.|                                .
Human   125 VIQMRPDLKGALLSLIEYYQW----DKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINN 185

  Fly    70 IKEDEFEGKGIPYNDWTL----RLTVAIERSHCETFIAFQEQIPEFARYF--YHASIYSIWRS-- 126
            .|:||....  .:.|..|    |:.:..||......:   :|:....::.  ||..|.::..:  
Human   186 DKKDEMYRS--LFQDLELKKERRVILDCERDKVNDIV---DQVITIGKHVKGYHYIIANLGFTDG 245

  Fly   127 --LRNRFMFVYTKEFE--DKKDSYLSGYI-------FQDQPNILVITSQYLNSSTF---EIKTNR 177
              |:.:|.......|:  |..||.:|.:|       .::.|.....|.:|.::.|:   ::.|..
Human   246 DLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEA 310

  Fly   178 FVGPRNFNK----------------NPE-------PVEFYILQ----------RFDAKGTKAT-- 207
            |   ||..|                ||.       .:|..:.|          :||..|.:..  
Human   311 F---RNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYT 372

  Fly   208 ----------------WE---------TQSAMSSKMRNLKGREVVIGIFDYKPFMLLDYEKPPL- 246
                            |.         |:....:....|:.:.||:......|::::......| 
Human   373 INIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLE 437

  Fly   247 ---YYDRFMNTTDVTID-----GTDIQLMLIFCELYNCTIQVDTSEPYDWGDIYLNASGYGLVGM 303
               .|:.:  ..|:..:     |...:|.::....|... ..||.   .|.         |:||.
Human   438 GNERYEGY--CVDLAAEIAKHCGFKYKLTIVGDGKYGAR-DADTK---IWN---------GMVGE 487

  Fly   304 ILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPNR----LISWTLLLRPFQFVLWMC 364
            ::..:.|..:..:.:.....|.:|.:......|::.::..|.:    :.|:   |.|..:.:|||
Human   488 LVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSF---LDPLAYEIWMC 549

  Fly   365 VMLCLLLESLALGITRR-----WEHSSVAAG---NSWISSLRFGCIS----TLKLFVNQSTNYVT 417
            ::...:..|:.|.:..|     |.......|   .|..|:..||..:    :|..|:.|..:...
Human   550 IVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISP 614

  Fly   418 SSYALRTVLVASYMIDIILTTVYSGGLAAILT----LPTLEEAAD-SRQRLFDHKLIWTGTSQAW 477
            .|.:.|.|....:...:|:.:.|:..|||.||    :..:|.|.| |:|....:..:.:|:::.:
Human   615 RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEF 679

  Fly   478 -----ITTIDE-----RSADP 488
                 |...|:     |||:|
Human   680 FRRSKIAVFDKMWTYMRSAEP 700

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir76aNP_001097647.3 None
GRIA2NP_000817.5 PBP1_iGluR_AMPA_GluR2 28..398 CDD:380612 57/349 (16%)
PBP2_iGluR_AMPA 413..794 CDD:270433 60/306 (20%)
Glutamate binding 499..501 0/1 (0%)