Protein Alignment Ir76a and GRIA2

DIOPT Version :10

• Sequence 1: NP_001097647.3
• Gene: Ir76a / 40157
• FlyBaseID: FBgn0260874
• Length: 646
• Species: Drosophila melanogaster
• Sequence 2: NP_000817.5
• Gene: GRIA2 / 2891
• HGNCID: 4572
• Length: 883
• Species: Homo sapiens
• Alignment Length: 671
• Identity: 119/671 - (17%)
• Similarity: 225/671 - (33%)
• Gaps: 215/671 - (32%)

  Fly     1 MENLLVESYYFSTVLSFFAQQF---------FADSHAT------CIFWHPAF---DFRLETVHPM 47
            ::||.|.:.:  .|.:.|..||         |.|..:.      |...|.:|   .|..:..||.
Human    62 IDNLEVANSF--AVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPF 124

  Fly    48 P-----------LIIMDWHRWANRSDQDVYDY--------------------------------K 69
            .           |.::::::|    |:..|.|                                .
Human   125 VIQMRPDLKGALLSLIEYYQW----DKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINN 185

  Fly    70 IKEDEFEGKGIPYNDWTL----RLTVAIERSHCETFIAFQEQIPEFARYF--YHASIYSIWRS-- 126
            .|:||....  .:.|..|    |:.:..||......:   :|:....::.  ||..|.::..:
Human   186 DKKDEMYRS--LFQDLELKKERRVILDCERDKVNDIV---DQVITIGKHVKGYHYIIANLGFTDG 245

  Fly   127 --LRNRFMFVYTKEFE--DKKDSYLSGYI-------FQDQPNILVITSQYLNSSTF---EIKTNR 177
              |:.:|.......|:  |..||.:|.:|       .::.|.....|.:|.::.|:   ::.|..
Human   246 DLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTTTIKYTSALTYDAVQVMTEA 310

  Fly   178 FVGPRNFNK----------------NPE-------PVEFYILQ----------RFDAKGTKAT-- 207
            |   ||..|                ||.       .:|..:.|          :||..|.:..
Human   311 F---RNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYT 372

  Fly   208 ----------------WE---------TQSAMSSKMRNLKGREVVIGIFDYKPFMLLDYEKPPL- 246
                            |.         |:....:....|:.:.||:......|::::......|
Human   373 INIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLE 437

  Fly   247 ---YYDRFMNTTDVTID-----GTDIQLMLIFCELYNCTIQVDTSEPYDWGDIYLNASGYGLVGM 303
               .|:.:  ..|:..:     |...:|.::....|... ..||.   .|.         |:||.
Human   438 GNERYEGY--CVDLAAEIAKHCGFKYKLTIVGDGKYGAR-DADTK---IWN---------GMVGE 487

  Fly   304 ILDRRNDYGVGGMYLWYEAYEYMDMTHFLGRSGVTCLVPAPNR----LISWTLLLRPFQFVLWMC 364
            ::..:.|..:..:.:.....|.:|.:......|::.::..|.:    :.|:   |.|..:.:|||
Human   488 LVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSF---LDPLAYEIWMC 549

  Fly   365 VMLCLLLESLALGITRR-----WEHSSVAAG---NSWISSLRFGCIS----TLKLFVNQSTNYVT 417
            ::...:..|:.|.:..|     |.......|   .|..|:..||..:    :|..|:.|..:...
Human   550 IVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISP 614

  Fly   418 SSYALRTVLVASYMIDIILTTVYSGGLAAILT----LPTLEEAAD-SRQRLFDHKLIWTGTSQAW 477
            .|.:.|.|....:...:|:.:.|:..|||.||    :..:|.|.| |:|....:..:.:|:::.:
Human   615 RSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEF 679

  Fly   478 -----ITTIDE-----RSADP 488
                 |...|:     |||:|
Human   680 FRRSKIAVFDKMWTYMRSAEP 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ir76a	NP_001097647.3	None
GRIA2	NP_000817.5	PBP1_iGluR_AMPA_GluR2	28..398	CDD:380612	57/349 (16%)
		PBP2_iGluR_AMPA	413..794	CDD:270433	60/306 (20%)
		Required for interaction with IQSEC1. /evidence=ECO:0000250|UniProtKB:P19491	867..877