DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ir76a and Grin2a

DIOPT Version :9

Sequence 1:NP_001097647.3 Gene:Ir76a / 40157 FlyBaseID:FBgn0260874 Length:646 Species:Drosophila melanogaster
Sequence 2:NP_036705.3 Gene:Grin2a / 24409 RGDID:2737 Length:1464 Species:Rattus norvegicus


Alignment Length:700 Identity:124/700 - (17%)
Similarity:233/700 - (33%) Gaps:230/700 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    46 PMPLIIMDWHRWANRSDQDVYDYKIKEDEFEGKGIPYNDWTLRLTVAIERSHCETFIAF------ 104
            |..||.:.:..|         ||.::....:|.||        ||.|.. |..|.|...      
  Rat   273 PSGLISVSYDDW---------DYSLEARVRDGLGI--------LTTAAS-SMLEKFSYIPEAKAS 319

  Fly   105 ---QEQIPEFARYFYHASIYSI-WRSLRNRFMFVYTKEFEDKKDSYLSGYIFQDQPNILVITSQY 165
               |.:.||...:..|..:.:: |                |.||...:...:|..|.::||.   
  Rat   320 CYGQAEKPETPLHTLHQFMVNVTW----------------DGKDLSFTEEGYQVHPRLVVIV--- 365

  Fly   166 LNSSTFEIKTNRFVGPRNFNKNPEPVEFYILQRFDAKGTKATWETQS-----AMSSKMRNLKGRE 225
                              .||:.|         ::..|   .||.|:     |:..:.::....|
  Rat   366 ------------------LNKDRE---------WEKVG---KWENQTLSLRHAVWPRYKSFSDCE 400

  Fly   226 -----VVIGIFDYKPFMLLDYEKPPLYYD---------RFMNTTDVTIDGTDIQLMLIFCELYNC 276
                 :.|...:..||:::: :..||...         :|:...:.|.:|.:::..   |:.:..
  Rat   401 PDDNHLSIVTLEEAPFVIVE-DIDPLTETCVRNTVPCRKFVKINNSTNEGMNVKKC---CKGFCI 461

  Fly   277 TIQVDTSEPYDWG-DIYLNASG----------YGLVGMILDRRNDYGVGGMYLWYEAYEYMDMTH 330
            .|....|....:. |:||..:|          .|::|.::.:|....||.:.:..|..|.:|.:.
  Rat   462 DILKKLSRTVKFTYDLYLVTNGKHGKKVNNVWNGMIGEVVYQRAVMAVGSLTINEERSEVVDFSV 526

  Fly   331 FLGRSGVTCLVPAPNRLISWTLLLRPFQFVLWMCVMLCLLLESL----------ALGITRRWEHS 385
            ....:|::.:|...|..:|.:..|.||...:|:.:.:.||:.|.          .:|..|.....
  Rat   527 PFVETGISVMVSRSNGTVSPSAFLEPFSASVWVMMFVMLLIVSAIAVFVFEYFSPVGYNRNLAKG 591

  Fly   386 SVAAGNS-------WISSLRFGCISTLKLFVNQSTNYVTSSYALRTVLVASY-MIDIILTTVYSG 442
            ....|.|       |   |.:|      |..|.|............::|:.: ...:|....|:.
  Rat   592 KAPHGPSFTIGKAIW---LLWG------LVFNNSVPVQNPKGTTSKIMVSVWAFFAVIFLASYTA 647

  Fly   443 GLAAILTLPTLEEAADSRQRLFDHKL--------------IWTGTSQ-----------AWITTID 482
            .|||.:   ..||..|....|.|.|.              :..|:::           .::|..:
  Rat   648 NLAAFM---IQEEFVDQVTGLSDKKFQRPHDYSPPFRFGTVPNGSTERNIRNNYPYMHQYMTRFN 709

  Fly   483 ERSADPVLL----GLMEHYRVYDANLISAFSHTEQ--------MGFVVERLQFGHLGNTELIEND 535
            :|..:..|:    |.::.: :|||.:::..:..::        .|::.....:|    ..|.:..
  Rat   710 QRGVEDALVSLKTGKLDAF-IYDAAVLNYKAGRDEGCKLVTIGSGYIFATTGYG----IALQKGS 769

  Fly   536 ALKRLKLMVDDIYFAFT----VAFVPRLWPHLNAYNDFILAWHSSGFDKFWEWKIAAEYMNAHRQ 596
            ..||   .:|.....|.    :..:..||.....:|:                           :
  Rat   770 PWKR---QIDLALLQFVGDGEMEELETLWLTGICHNE---------------------------K 804

  Fly   597 NRIVASEKTNLDIGPVKLGIDNFIGLILLWCFGMICSLLTFLGE---LWR 643
            |.:::|:          |.|||..|:..:....|..||:||:.|   .|:
  Rat   805 NEVMSSQ----------LDIDNMAGVFYMLAAAMALSLITFIWEHLFYWK 844

Known Domains:


Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

GeneSequenceDomainRegion External IDIdentity
Ir76aNP_001097647.3 None
Grin2aNP_036705.3 PBP1_iGluR_NMDA_NR2 32..392 CDD:107373 35/185 (19%)
PBP2_iGluR_NMDA_Nr2 403..802 CDD:270436 73/422 (17%)
HisJ <458..>541 CDD:223904 16/82 (20%)
Glutamate binding. /evidence=ECO:0000269|PubMed:16281028, ECO:0007744|PDB:2A5S, ECO:0007744|PDB:2A5T, ECO:0007744|PDB:4NF4, ECO:0007744|PDB:4NF8, ECO:0007744|PDB:5I56, ECO:0007744|PDB:5I57, ECO:0007744|PDB:5I58, ECO:0007744|PDB:5I59, ECO:0007744|PDB:5JTY 511..513 0/1 (0%)
Lig_chan 556..828 CDD:278489 51/328 (16%)
Pore-forming. /evidence=ECO:0000250|UniProtKB:B7ZSK1 599..620 6/29 (21%)